• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Cycling Curcumin Supplements

curcumin tumeric supplement

  • Please log in to reply
10 replies to this topic

#1 brighty

  • Guest
  • 28 posts
  • 8
  • Location:New York

Posted 17 July 2016 - 02:05 PM


Hi,

 

I am currently taking curcumin supplement for antiaging and preventive purposes. I learned that different curcumin formulations utilize different pathways in the body. Is it a good idea to cycle different curcumin supplements every two months rather than staying with the same curcumin supplement all the time? I am considering cycling BCM-95 with either Metacurcumin or Longvida every two months.

 

Thanks,
Brighty



#2 Dorian Grey

  • Guest
  • 2,152 posts
  • 968
  • Location:kalifornia

Posted 17 July 2016 - 04:55 PM

I take what I believe is called "micronized" enhanced absorption curcumin (Life Extension Super Bio-Curcumin) rather than the curcumin/piperine enhanced formulas (C-3).  

 

The piperine formulas are supposed to enhance blood levels of curcumin by interfering with glucuronidation (a detoxification pathway) of curcumin in the liver.  

 

I actually haven't found anything all that spooky about the piperine/glucuronidation issue, but I simply wish to avoid it if I can, and the micronized enhanced absorption formulas seem to do this quite well.  

 

I also add a cheap Turmeric supplement I take with a different meal as I've read there are some co-factors in turmeric that may be helpful/augment the action of curcumin.  

 

I'm interested in hearing others opinions on this myself.  


Edited by synesthesia, 17 July 2016 - 05:00 PM.

  • Good Point x 1

sponsored ad

  • Advert
Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

#3 Kalliste

  • Guest
  • 1,147 posts
  • 158

Posted 17 July 2016 - 07:09 PM

I prefer to cycle curcumin, it has a definitive negative impact on my libido, where fasting and HIT will boost my orgasms curcumin seems to diminish them by a lot. For several years I consumed it almost daily, I started to wonder if my lust for sex and masturbation was simply disappearing with age! What a waste of pleasure it was!

 

However the prospects of curcumin are too good for me to ignore it so I will have a week without it then cook two or three days with Turmeric roots, turmeric powder and curry powder.

 

 

Buy and eat the real Turmeric roots. There are many unknown components of Turmeric which are a part of the healthy effects, there have been trials of Turmeric chemically stripped of it's curcumin content which still show anti-cancer activity. 

 

The roots cannot be heated for too long, I add them to my cooking at the end.

For taste and added synergy I consume it with olive oil and generous amounts of curry powder.

I add some turmeric powder just in case the actual milling and grinding process generates some additional beneficial effects.

Goes well with chicken and eggs (LCHF meal)

 

Do a Pubmed search for each component of curry, each component has a health promoting effect and with the Protandim* trials in mind there are probably many synergies to be had.

 

When cooking my Turmeric roots I will use one out of two curry powders;

 

1. Mild Curry: with no added salt but with an extensive array of ingredients: coriander, turmeric, cumin, fenugreek, ginger, garlic and black pepper.

 

2. Hot Curry: no added salt but with an extensive array of ingredients: coriander, turmeric, cumin, fenugreek, chili peppers, ginger, garlic, asafoetida, fennel seed, caraway, cinnamon, clove, mustard seed, green cardamom, black cardamom, nutmeg, long pepper, and black pepper.

 

I usually drink some coffee a few hours before and some green tea and a small glass of red wine after the meal, for the most extensive synergies that I believe exist between all of these compounds to take place.

 

* Protandim is an expensive dietary supplement consisting some basic supplements well known on this board, read this paper for instance.

My key take-away was the fact that low dose of multiple substances has a powerful synergistic effect. The sum is more than the parts!

http://www.ncbi.nlm....pubmed/16413416

 

** Large amounts of green tea also seems to decrease my libido by the way. But not as badly.


  • Good Point x 1
  • Informative x 1

#4 hamishm00

  • Guest
  • 1,053 posts
  • 94
  • Location:United Arab Emirates

Posted 19 July 2016 - 10:36 AM

I also add a cheap Turmeric supplement I take with a different meal as I've read there are some co-factors in turmeric that may be helpful/augment the action of curcumin.  

 

I'm interested in hearing others opinions on this myself.  

 

This is a very good idea. Turns out that the curcumin is far from the only active ingredient in turmeric. In fact if you extract curcumin from tumeric and use what's left, the leftovers are more effective than curcumin at reducing inflammation and cancer, proving once again that it's often the actual combination of different things in herbs/spices that give beneficial effects and not a single extract.


Edited by hamishm00, 19 July 2016 - 10:37 AM.

  • Needs references x 1
  • Agree x 1

#5 joelcairo

  • Guest
  • 586 posts
  • 156
  • Location:Calgary, Alberta, Canada
  • NO

Posted 19 July 2016 - 03:54 PM

I'd need to see a reference for that claim before accepting it as true. Non-curcumin curcuminoids are bioactive and have some similar effect, but I don't recall seeing any study where they were more effective.

 

As for the original question, I use multiple curcumin formulations in proportionately smaller doses at the same time, rather than cycling them. I seriously doubt there is much actual research into which of these strategies is best.



#6 Kalliste

  • Guest
  • 1,147 posts
  • 158

Posted 20 July 2016 - 07:02 PM

 

 
Biofactors. 2013 Mar-Apr;39(2):221-32. doi: 10.1002/biof.1054. Epub 2012 Dec 11.
Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis. Abstract Abstract

Curcumin (CUR), a yellow pigment in turmeric, has marked potential for preventing colon cancer. We recently reported that ar-turmerone (ATM) suppressed nitric oxide (NO) generation in macrophages. In the present study, we explored the molecular mechanisms by which ATM attenuates NO generation and examined the anti-carcinogenesis activity of turmerones (TUR, a mixture of 5 sesquiterpenes including ATM). Both CUR and ATM inhibited lipopolysaccharide (LPS)-induced expression of inducible forms of both nitric oxide synthase and cyclooxygenase (iNOS and COX-2, respectively). A chase experiment using actinomycin D revealed that ATM accelerated the decay of iNOS and COX-2 mRNA, suggesting a post-transcriptional mechanism. ATM prevented LPS-induced translocation of HuR, an AU-rich element-binding protein that determines mRNA stability of certain inflammatory genes. In a colitis model, oral administration of TUR significantly suppressed 2% dextran sulfate sodium (DSS)-induced shortening of the large bowel by 52-58%. We also evaluated the chemopreventive effects of oral feeding of TUR, CUR, and their combinations using a model of dimethylhydradine-initiated and DSS-promoted mouse colon carcinogenesis. At the low dose, TUR markedly suppressed adenoma multiplicity by 73%, while CUR at both doses suppressed adenocarcinoma multiplicity by 63-69%. Interestingly, the combination of CUR and TUR at both low and high doses abolished tumor formation. Collectively, our results led to our hypothesis that TUR is a novel candidate for colon cancer prevention. Furthermore, we consider that its use in combination with CUR may become a powerful method for prevention of inflammation-associated colon carcinogenesis.

 

 

J Agric Food Chem. 2012 Sep 26;60(38):9620-30. Epub 2012 Sep 12.
Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells.
Abstract

The mechanisms underlying the antiproliferative and antitumor activities of aromatic turmerone (ar-turmerone), a volatile turmeric oil isolated from Curcuma longa Linn., have been largely unknown. In this study, 86% pure ar-turmerone was extracted by supercritical carbon dioxide and liquid-solid chromatography and its potential effects and molecular mechanisms on cell proliferation studied in human hepatocellular carcinoma cell lines. Ar-turmerone exhibited significant antiproliferative activity, with 50% inhibitory concentrations of 64.8 ± 7.1, 102.5 ± 11.5, and 122.2 ± 7.6 μg/mL against HepG2, Huh-7, and Hep3B cells, respectively. Ar-turmerone-induced apoptosis, confirmed by increased annexin V binding and DNA fragmentation, was accompanied by reactive oxygen species (ROS) production, mitochondrial membrane potential dissipation, increased Bax and p53 up-regulated modulator of apoptosis (PUMA) levels, Bax mitochondrial translocation, cytochrome c release, Fas and death receptor 4 (DR4) augmentation, and caspase-3, -8, and -9 activation. Exposure to caspase inhibitors, Fas-antagonistic antibody, DR4 antagonist, and furosemide (a blocker of Bax translocation) effectively abolished ar-turmerone-triggered apoptosis. Moreover, ar-turmerone stimulated c-Jun N-terminal kinase (JNK) and extracellular signal-related kinase (ERK) phosphorylation and activation; treatment with JNK and ERK inhibitors markedly reduced PUMA, Bax, Fas, and DR4 levels and reduced apoptosis but not ROS generation. Furthermore, antioxidants attenuated ar-turmerone-mediated ROS production; mitochondrial dysfunction; JNK and ERK activation; PUMA, Bax, Fas, and DR4 expression; and apoptosis. Taken together, these results suggest that ar-turmerone-induced apoptosis in HepG2 cells is through ROS-mediated activation of ERK and JNK kinases and triggers both intrinsic and extrinsic caspase activation, leading to apoptosis. On the basis of these observations, ar-turmerone deserves further investigation as a natural anticancer and cancer-preventive agent.

 

 

 

December 2015, Volume 33, Issue 6, pp 1175-1186

First online:

02 November 2015
Identification of a novel compound (β-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin
Summary

Considering that as many as 80 % of the anticancer drugs have their roots in natural products derived from traditional medicine, we examined compounds other than curcumin from turmeric (Curcuma longa) that could exhibit anticancer potential. Present study describes the isolation and characterization of another turmeric-derived compound, β-sesquiphellandrene (SQP) that exhibits anticancer potential comparable to that of curcumin. We isolated several compounds from turmeric, including SQP, α-curcumene, ar-turmerone, α-turmerone, β-turmerone, and γ-turmerone, only SQP was found to have antiproliferative effects comparable to those of curcumin in human leukemia, multiple myeloma, and colorectal cancer cells. While lack of the NF-κB-p65 protein had no effect on the activity of SQP, lung cancer cells that expressed p53 were more susceptible to the cytotoxic effect of SQP than were cells that lacked p53 expression. SQP was also found to be highly effective in suppressing cancer cell colony formation and inducing apoptosis, as shown by assays of intracellular esterase activity, plasma membrane integrity, and cell-cycle phase. SQP was found to induce cytochrome c release and activate caspases that lead to poly ADP ribose polymerase cleavage. SQP exposure was associated with downregulation of cell survival proteins such cFLIP, Bcl-xL, Bcl-2, c-IAP1, and survivin. Furthermore, SQP was found to be synergistic with the chemotherapeutic agents velcade, thalidomide and capecitabine. Overall, our results indicate that SQP has anticancer potential comparable to that of curcumin.

 

 

J Med Food. 2012 Mar;15(3):242-52. doi: 10.1089/jmf.2011.1845. Epub 2011 Dec 19.
The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells.
Abstract

The rhizome of Curcuma longa (turmeric) is often used in Asia as a spice and as a medicine. Its most well-studied component, curcumin, has been shown to exhibit poor bioavailability in animal studies and clinical trials. We hypothesized that the presence of lipophilic components (e.g., turmerones) in turmeric extract would affect the absorption of curcumin. The effects of turmerones on curcumin transport were evaluated in human intestinal epithelial Caco-2 cells. The roles of turmerones on P-glycoprotein (P-gp) activities and mRNA expression were also evaluated. Results showed that in the presence of α- and aromatic turmerones, the amount of curcumin transported into the Caco-2 cells in 2 hours was significantly increased. α-Turmerone and verapamil (a P-gp inhibitor) significantly inhibited the efflux of rhodamine-123 and digoxin (i.e., inhibited the activity of P-gp). It is interesting that aromatic turmerone significantly increased the rhodamine-123 efflux and P-gp (MDR1 gene) mRNA expression levels. The effects of α- and aromatic turmerones on curcumin transport as well as P-gp activities were shown here for the first time. The presence of turmerones did affect the absorption of curcumin in vitro. These findings suggest the potential use of turmeric extract (including curcumin and turmerones), rather than curcumin alone, for treating diseases.

 

There are probably many other things beyond Curcumin to be had with the entire root.

 

There is some indication that Turmeric might potentiate the anti-cancer effectiveness of Aspirin so sometimes I will eat 75mg of aspirin after my Turmericroot-Curcuminpowder-Currypowder-Oliveoil-Ginger meal :-D

 

This could not be quoted

Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo

http://stemcellres.b...10.1186/scrt500


  • Informative x 4
  • WellResearched x 1

#7 Dorian Grey

  • Guest
  • 2,152 posts
  • 968
  • Location:kalifornia

Posted 21 July 2016 - 02:32 AM

Thanks for doing our homework for us Cosmicalstorm...  Great Reading!  



#8 Kinesis

  • Guest
  • 262 posts
  • 27
  • Location:Pennsylvania USA
  • NO

Posted 22 July 2016 - 11:27 PM

I take what I believe is called "micronized" enhanced absorption curcumin (Life Extension Super Bio-Curcumin) rather than the curcumin/piperine enhanced formulas (C-3).

The piperine formulas are supposed to enhance blood levels of curcumin by interfering with glucuronidation (a detoxification pathway) of curcumin in the liver.

I actually haven't found anything all that spooky about the piperine/glucuronidation issue, but I simply wish to avoid it if I can, and the micronized enhanced absorption formulas seem to do this quite well.

I also add a cheap Turmeric supplement I take with a different meal as I've read there are some co-factors in turmeric that may be helpful/augment the action of curcumin.

I'm interested in hearing others opinions on this myself.


Agreed. I prefer either turmeric or broad spectrum extracts to isolated curcumin. Some of the newer research has identified compounds in turmeric besides curcumin with remarkable benefits - e.g. do a google or pubmed search for turmerones or ar-turmerone - and who knows what next year's research will find?

#9 brighty

  • Topic Starter
  • Guest
  • 28 posts
  • 8
  • Location:New York

Posted 23 July 2016 - 10:52 AM

The problem is we are not sure how well our bodies absorb plain turmeric extracts other than curcumin. At least, there are various proven supplements that help us absorb curcumin. But we do not know how much of the turmeric extracts we absorb if we just take it with the food or try the turmeric extracts supplements out there.

 

Brighty

 

 



#10 Kalliste

  • Guest
  • 1,147 posts
  • 158

Posted 23 July 2016 - 11:58 AM

Consider that there is a huge market for Curcumin these days, lots of money to be made if you massage a study that shows how your special patented Curucmin brand is so much better than anything else.

 

Personally I believe in the cocktail effect. Google the term if you are unsure about it. I think it works positively as well as it works negatively.

Perhaps you don't need massive blood-levels if you got many synergies going on, sometimes you should not stare yourself blind on blood panels and numbers.

 

The cocktail-effect is probably why so many isolation trials of different substances fail even though the underlying theory and observations from nature are good.

There is a lot of indication that the best treatment for cancer and cancer-prevention lies in multi-targeting a vast number of cellular signaling pathways using a large number of different substances (I.e fasting+HIT+meditation+paleo-diet).

 

Margarets Corner is a nice curcumin-oriented blog. She always goes back to the powder/root after trying different cur-supplements.

http://margaret.healthblogs.org/

 


Edited by Cosmicalstorm, 23 July 2016 - 12:00 PM.


sponsored ad

  • Advert
Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

#11 Kalliste

  • Guest
  • 1,147 posts
  • 158

Posted 29 July 2016 - 08:28 AM

This one popped up in my curcumin feed today

 

 

J Cancer 2016; 7(10):1250-1257. doi:10.7150/jca.15690

Research Paper

Curcumin Sensitizes Silymarin to Exert Synergistic Anticancer Activity in Colon Cancer Cells

Amanda Montgomery1, Temitope Adeyeni2,3, KayKay San3, Rita M. Heuertz3, Uthayashanker R. Ezekiel3 email.gif

1. Department of Nutrition and Dietetics, Saint Louis University St. Louis, MO 63104, USA;
2. Department of Health Science and Informatics, Saint Louis University St. Louis, MO 63104, USA;
3. Biomedical Laboratory Science, Saint Louis University St. Louis, MO 63104, USA.

How to cite this article:
Montgomery A, Adeyeni T, San K, Heuertz RM, Ezekiel UR. Curcumin Sensitizes Silymarin to Exert Synergistic Anticancer Activity in Colon Cancer Cells. J Cancer 2016; 7(10):1250-1257. doi:10.7150/jca.15690. Available from http://www.jcancer.org/v07p1250.htm
Abstract

We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in their action against cancer cell proliferation. Curcumin is the major component of the spice turmeric. Silymarin is a bioactive component of milk thistle used as a protective supplement against liver disease. We studied antiproliferative effects of curcumin alone, silymarin alone and combinations of curcumin and silymarin using colon cancer cell lines (DLD-1, HCT116, LoVo). Curcumin inhibited colon cancer cell proliferation in a concentration-dependent manner, whereas silymarin showed significant inhibition only at the highest concentrations assessed. We found synergistic effects when colon cancer cells were treated with curcumin and silymarin together. The combination treatment led to inhibition of colon cancer cell proliferation and increased apoptosis compared to single compound treated cells. Combination treated cells exhibited marked cell rounding and membrane blebbing of apoptotic cells. Curcumin treated cells showed 3-fold more caspase3/7 activity whereas combination treated cells showed 5-fold more activity compared to control and silymarin treated cells. When DLD-1 cells were pre-exposed to curcumin, followed by treatment with silymarin, the cells underwent a high amount of cell death. The pre-exposure studies indicated curcumin sensitization of silymarin effect. Our results indicate that combinatorial treatments using phytochemicals are effective against colorectal cancer.

 







Also tagged with one or more of these keywords: curcumin, tumeric, supplement

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users