I came across very informative threads on Memantine here:
http://www.longecity...xibility/page-2 (page 2 only)
and here:
http://www.longecity...se/#entry726312
I understand from various studies, that Memantine is known to be helpful in social anxiety, OCD, GAD, ADHD, and neuropathic pain in addition to the approved use in Alzheimer diseases (not very helpful from what i hear): https://en.wikipedia.../wiki/Memantine
So, I decided to do a Memantine trial to see if it helps with my (supposed) adult ADHD. I tried clonidine before for ADHD, but it made me sleepy, tired, and depressed, even in small doses and when taken in evenings. I had some response in the past to NAC, DMAE, piracetam, and tyrosine, but they were minimal.
I started with 5mg dose of Memantine (1/2 pill) per day at late morning. The first effect were felt 2-3 hrs with some weird subjective mental feeling (minimal) and sudden realization that colors are so much brighter that usual. This is the first time in my life that I perceive colors that strongly. I did some reading and some people reported that after taking nootropics. I didn't respond to piracetam like this in the past, but I'm currently taking piracetam and Memantine together, so that's a possibility. Another possibility is the D2 agonist or anti-ACh action as some people believe that it can increase color brightness/saturation: https://www.reddit.c...could_possibly/
Another effect I noticed at 4-6 hrs was lifting of social anxiety and smoother conversation with my coworkers. At the same time, there was a slight talking impairment, but probably subjective, and noone seemed to notice any slurred speech. So, this could be that dumbing effect of ACh receptor antagonism.
At the end of the day, I did some exercising and noticed I was a bit more motivated to do it. I usually find excuses not to do it and I skip it often.
Today I did another 5mg (together with my coffee, vitamins, fish oil, and piracetam/NAC/DMAE combo) in early AM, and noticed a significant mood improvement, increased self esteem, and a surprising motivation to cook breakfast that I usually skip because of laziness in AM. At work, I was more focused on tasks and more efficient to finish them. I dictated a few reports and had a few meetings that went super smoothly. Looks like my ADHD (or rather ADD or SCT or whatever I have) was lifted by either Memantine or the whole supplement combo (see above). Time will tell if that effect lasts long.
Lastly, as I type this, I do notice quite a few misspellings and typos (thanks God for spellchecks, LOL). Likely more that usual, but not by a huge margin (I'm sort of dyslexic, too). Be my guest to judge if this sound coherent enough for English as a second language person.
Based on the initial effects, it sounds like my entire family could use Memantine (we are all ADHD and/or anxiety with a few borderline family members).
I'll keep you posted.
The only thing that gives me a pause is that revelation that Memantine created neuro problems in patients with multiple sclerosis: https://www.ncbi.nlm...pubmed/19092106
Why would that be? I would like to know.
Thanks for listening/reading.