2 replies to this topic

[Heisenburger]

Can anybody parse this paragraph from the Wiki page on Dihexa into more easily digestible Anglo-Saxonisms that my feeble mind could potentially curl itself around? Is it suggesting that Dihexa is carcinogenic, or that it is not carcinogenic?

 

According to a patent, "Short duration safety studies with Dihexa have uncovered no apparent toxicity. Of particular note is a lack of neoplastic induction, since c-Met is recognized as an oncogene. This is unsurprising since oncogenesis requires multiple mutations including both oncogene induction and tumor suppressor attenuation."

 

[telight]

Its basically saying that since dihexa increases HGF it would increase the activity at the HGF receptor or HGFR also known as c-Met. Activation of this receptor is associated with normal cells becoming tumors, but in short duration studies it doesn't seem to produce any tumors. This might seem surprising at first until you learn that in order for a cell to become a tumor cell it needs not only action of the HGFR (or c-Met) but also a suppresion of other biological factors that work to reduce tumors. So the increased HGFR activation is necessary but not sufficient condition for creating tumor cells. Therefore dihexa alone cannot create tumor cells. But if you had some other disorder which led to a suppression of the factors that reduce tumor cells, the extra activation of HGFR by dihexa would most likely lead to increased tumor cells. You probably shouldn't take dihexa if you have had tumors in the past.

Edited by telight, 24 July 2016 - 11:42 PM.

[BieraK]

So beside c60, what other compound with anti-tumor effects is better to take with Dihexa?
I'm thinking in Luteolin or Resveratrol.