Testosterone and Pregnenolone are not sustainable in the long-term.
Btw, have you had your testosteron checked? If you really have issues with that, then you might get something prescribed legally and correctly.
You mention Attention Deficit - have you been evaluated for neuropsychiatric disorders?
You do sound as if you might have some ADD/SCT/CDD symptoms. Have you checked yourself against the symptom-list on wiki?
https://en.wikipedia...cognitive_tempo
If you really have SCT, then your problem may not be dopaminergic - most signs points towards the bigger component being Norepinephrine actually.
It has to do with the Sub-activity in the Superior Parietal Lobe - an area of the brain which responds mostly to norepinephrine - without it, your cognition and attention slows to a crawl.
Now, could you rate your med's in order of how much you felt that they helped? For me, this is the order:
Bupropion ~ 15-20%
Modafinil ~ 20%
Ritalin/Concerta/Medikinet (ANY methylphenidate formulation, really) ~ 25%
Vyvanse (lisdexamphetamine) ~35%
I'm particularly curious about Reboxetine... if your problem is norepinephrinergic, then it should have helped. Strattera (atomoxetine) is generally considered more helpful, but it's not entirely clear why. It's theorized to be connected to the fact that Atomoxetine also causes more direct PFC norepinephrine and DOPAMINE release, (SCT is probably in reverse regarding the relationship between DA and NE, as opposed to ADHD) as well as the fact that Atomoxetine is actually an NMDA-antagonist at clinical doses.
I know Strattera has the worst rep' in the world, but IMHO, it's partially unwarranted, mainly because it's given to the WRONG set of patients.
ADHD-ers won't be helped much by strat, so they'll be feeling the side-effects and then some. ADD/SCT/CDD-ers however... WE will be helped immensely by it.
The problem with terrible anxiety, even suicidal ideation, which has been reported so often as a side-effect of Strattera (it's always temporary though) is probably connected to the Opiate Kappa-Receptor agonism which one of its metabolites express. The combo of kappa-agonism and NE, makes it feel as if you're super-stressed and failing all the time - hence the harsh response to the drug.
You should be able to easily counter it with Tianeptine though - OR... even better... JOIN THE CERC-501 KAPPA *ANTAGONIST* GROUP BUY! ^^ With Cerc-501, you won't be feelin' JACK SH*T of that stress-effect - it blocks all of that agonism, and makes the stress far more bearable.
There's also the curious effect of Kappa-antagonism hypothetically enhancing dopaminergic release to some extent. (this effect is only hypotethical, since kappa-agonists have been shown to inhibit dopamine to some extent - some kind of down-stream effect - the kappa's tell your brain your being punished, hence it releases less dopamine. possibly.)
Right, here's my recommendations, based on the idea that you have Sluggish Cognitive Tempo:
1. Vyvanse + INTUNIV (I cannot stress how important the intuniv aka guanfacine is - without it, vyvanse just isn't enough. remember to use low dosage vyvanse as well. 20 mg's should be more than enough)
2. Strattera + Tianeptine
3. Metadoxine (a drug which enhances NE and DA production, as well as causing upregulation of the Gaba-receptors - it's been shown to increase reaction-speed)
4. Pyritinol (a form of vitamine B6, chemically related to metadoxine, also shown to increase reaction-speed)
There is also the possibility of adding #3 and #4 to #1 and #2, but best to test without it first.
Edited by Stinkorninjor, 21 August 2016 - 03:23 PM.
