2 replies to this topic

[Kierkegaardian]

My doc suspects I have excessive norepinephrine/stress signalling issues, and also thinks I should try to increase dopamine.  But he also recommended 2,000 mg ascorbic acid, which seems to contradict his intentions, seeing how vitamin C/ascorbic acid is a cofactor for dopamine-beta-hydroxylase, which converts dopamine to norepinephrine, yielding more norepinephrine and presumably less dopamine.  

 

Thoughts?

[thedevinroy]

Look up PMC2649700 and go to section 3.2 and you will see that only in extremely deficient mice were there dopamine/norepinephrine ratio problems. Even with slight acorbate levels, the ratio returned to normal within 8 weeks. So, unless you are planning on being completely deprived of vitamin C, your dopamine ratios won't get out of whack. There is evidence that there is some dopamine antagonism at pharmaceutically relevant doses (see resource 169). If you find it anxiogenic, tell your doctor.

Edited by devinthayer, 24 August 2016 - 10:24 PM.

[OneScrewLoose]

By the way, this is the same line of thinking that causes people to think that magneseum is an NMDA antagonist. There is a magnesium molecule inside every NMDA receptor to control the receptor's firing, and it would take some kind of extreme deficiency to change that. Adding more magnesium isn't going to change anything, as there is only one magnesium ion per NMDA ion channel.