One of the most spectacular feats of such creatures as bats, bees and snakes is hibernation. For months at a time, these animals essentially go into power-save mode. Their temperature drops, metabolism slows down and oxygen consumption is limited to minimal levels.
This basic adaptation helps them survive the harshest of environmental conditions.
A new study raises the extraordinary possibility that humans may be able to put themselves into a kind of hibernation state as well — but in a way that hurts us rather than helps us.
The research, published recently in the Proceedings of the National Academy of Sciences, focuses on the devastating condition known as myalgic encephalomyelitis, more popularly known as chronic fatigue syndrome. CFS is one of the biggest mysteries of modern medicine and is characterized by severe fatigue and related issues such as headaches and memory problems. According to conservative estimates, 2.5 million people in the United States suffer from it, but no cause has ever been pinpointed. That has made some doctors so skeptical of the diagnosis that many patients complain that they have sought help, only to be told the symptoms are in their heads.
The PNAS study, led by University of California at San Diego researcher Robert K. Naviaux, looked at metabolites in the bodies of people with CFS and those without the condition. The number of participants was small — just 84 people, 45 with CFS symptoms and 39 who served as a control.
[Journalist with CFS: I'm disabled. Can NIH spare a few dimes?]
Naviaux looked at 612 different metabolites, which are intermediate substances such as glucose produced by cells as they break down larger molecules and produce energy. They found that 80 percent of the metabolites were lower in those with CFS. They also found what they described as “abnormalities” in 20 of the metabolic pathways.
All this suggests that the metabolism of people with CFS is markedly slowed down.
The researchers said it appears to be similar to the “dauer state” in nematode worms when they are faced with starvation, overcrowding or other toxic environments. The dauer state involves a massive slowdown of the metabolism — an ability that has been of great interest to researchers for years because it is adaptive and is essentially a “non-aging” state when no cell death occurs. Cynthia Kenyon, a University of California at San Francisco scientist who now works for Google’s Calico start-up, gained fame for doubling the life span of a worm by altering a single gene that regulates the dauer state.
https://www.washingt...of-hibernation/
Edited by marcobjj, 17 September 2016 - 05:30 AM.
