• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Does Choline have merit in treating Depression?

choline depression cortisol

  • Please log in to reply
3 replies to this topic

#1 agwoodliffe

  • Guest
  • 120 posts
  • 15
  • Location:London

Posted 05 October 2016 - 06:34 PM


There's a study here which shows, quite surprisingly, that Choline blocks the a3b4 nicotinic receptor in a similar fashion to conventional antagonist Hexamethonium:

https://isccb12.webs...al/38-Rubio.pdf

 

I suspect this receptor has a part to play in depression, because another drug, Mecamylamine, has been shown in numerous studies to have anti-depressive effects, as well as attenuating effects of stress hormones:

https://www.ncbi.nlm...pubmed/19404193

https://www.ncbi.nlm...pubmed/25315361

https://www.ncbi.nlm...pubmed/18480694

https://www.ncbi.nlm...pubmed/19874251

 

From what I've read, The a3b4 receptor is a key target of Mecamylamine, the other being the a4b2 receptor.

 

So am I onto something or am I talking a load of blarney?

 

Bear in mind, supplement companies typically sell choline in combination with another compound called Inositol, which has demonstrated anti-depressive effects also (I believe levels are too high when a person experiences mania).



#2 FunkOdyssey

  • Guest
  • 3,443 posts
  • 166
  • Location:Manchester, CT USA

Posted 05 October 2016 - 08:04 PM

95% of discussions on this forum and elsewhere on the internet about choline and depression relate to choline causing depression:

 

https://www.google.c...w.longecity.org


  • Agree x 2

sponsored ad

  • Advert
Advertisements help to support the work of this non-profit organisation. To go ad-free join as a Member.

#3 normalizing

  • Guest
  • 2,692 posts
  • -104
  • Location:Warm Greetings
  • NO

Posted 05 October 2016 - 08:10 PM

choline supplements of various types did cause me depression too so....



sponsored ad

  • Advert
Advertisements help to support the work of this non-profit organisation. To go ad-free join as a Member.

#4 jack black

  • Guest
  • 1,294 posts
  • 28
  • Location:USA
  • NO

Posted 05 October 2016 - 08:27 PM

more choline = more acetylcholine = more depression (in susceptible individuals).

http://mindrenewal.us/page13.html







Also tagged with one or more of these keywords: choline, depression, cortisol

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users