8 replies to this topic

[normalizing]

as mentioned in another forum about brain inflammation and addiction, cytokines can play a role in this and people suggested inhibiting them to get anti inflammatory results and anti addictive potential.

here, some intro;

Cytokines are crucial for fighting off infections and in other immune responses.^[18] However, they can become dysregulated and pathological in inflammation, trauma, and sepsis.^[18]

Adverse effects of cytokines have been linked to many disease states and conditions ranging from schizophrenia, major depression^[19] and Alzheimer's disease^[20] to cancer.^[21] Normal tissue integrity is preserved by feedback interactions between diverse cell types mediated by adhesion molecules and secreted cytokines; disruption of normal feedback mechanisms in cancer, threatens tissue integrity.

 

can someone help me out here and compile substances that can help mitigate the dangerous effects of cytokine overproduction???

[normalizing]

there you go, i found more information on inhibiting cytokines and its relation to depression; http://www.medicalne...cles/313551.php

[SoundsAboutRight]

just came across this thread, but LostFalco put together a stack for this exact issue.

 

Link: http://www.lostfalco...n-fog-two-step/

 

Galantamine is a positive allosteric modulator of α7 nAChRs, inhibits the breakdown of acetylcholine, and activates the cholinergic anti-inflammatory pathway.

 

Answer: No. Activating the cholinergic anti-inflammatory pathway simply changes the immune response “set-point” from a toxic to a healthy level by reducing pro-inflammatory cytokine production by 50–75%.

[ceridwen]

Doesn't seem to do too much for me other than make me feel calm.
Does it work better if you take these for a while?

[Benko]

One is the ayurvedic herb Bacopa

 

Not sure why I am having trouble pasting the link but journal reference is

 

PMID 27473605

 

I believe bacopa can also have beneficial effects on the hippocampus.
 

 

Indian herbs are not infrequently contaminated so I'd buy from someplace with good quality control such as Banyan botanicals or Himalaya

Edited by Benko, 21 June 2017 - 10:31 PM.

[HaplogroupW]

Ketone bodies:

 

https://jneuroinflam...1742-2094-11-99

 

I'd suggest doing some searching on the effects of a ketogenic diet and inflammation.

 

http://thepaleodiet....nic-diet/#_ftn7

 

Or fasting works too (on a non-keto diet), just takes a while longer to get into ketosis.

 

I found after going keto, my decades-long persistent heartburn/gastritis/GERD resolved after a couple months.

Edited by HaplogroupW, 15 August 2017 - 05:04 AM.

[Multivitz]

Boron and iodine stops the fluoride.
Then see how you feel mmm.

[normalizing]

interesting. i wish more people contribute though

[HaplogroupW]

A recent result showing effect of restricted glucose availability on brain inflammation by decreasing NF-κB transcriptional activity:

 

https://www.nature.c...467-017-00707-0

 

Here is a an article about it:

https://www.medicaln...cles/319549.php

 

where the researcher says:

 

"We were surprised by the magnitude of our findings," said Dr. Swanson. "Inflammation is controlled by many different factors, so we were surprised to see such a large effect by manipulating this one factor. It reinforces the powerful effect of diet on inflammation."