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Using NAC to Boost Glutathione


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6 replies to this topic

#1 JR7

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Posted 26 October 2016 - 08:25 PM


Hello,
I was wondering if there are any known negative issues using supplemental N-acetyl-cystein?


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#2 ceridwen

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Posted 26 October 2016 - 10:16 PM

Lots do a search for this.
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#3 VP.

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Posted 27 October 2016 - 03:04 AM

http://medicalxpress...ed-decline.html

 

 

 

The researchers state that NAC iboosts the metabolic function of glutathione as well as increasing its rate of synthesis. It is currently used in emergency medicine to assist patients in a toxic crisis, for example ingestion of poisonous levels of heavy metals. It is known to be a very safe compound to utilize even at particularly high levels. Furthermore, the scientists believe that it may have significant value at much lower doses for maintaining glutathione levels and improving health. "I'm optimistic there could be a role for this compound in preventing the increased toxicity we face with aging, as our abilities to deal with toxins decline," Hagen stated. "We might be able to improve the metabolic resilience that we're naturally losing with age."

Hagen believes that there appears to be a wide range of detoxification potential offered by glutathione. High levels of it in conjunction with NAC may help reduce the toxicity of cancer chemotherapies, certain prescription drugs, and treat other health problems. The researchers concluded that "Using NAC as a prophylactic, instead of an intervention, may allow glutathione levels to be maintained for detoxification in older adults,"

 


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#4 RWhigham

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Posted 27 October 2016 - 07:58 PM

https://www.scienced...70904175353.htm  "One Type of Antioxidant May Not be as Safe as Once Thought"   According to new research an antioxidant commonly used in nutritional and body-building supplements can form a red blood cell-derived molecule that makes blood vessels think they are not getting enough oxygen. This leads to pulmonary arterial hypertension, a serious condition characterized by high blood pressure in the arteries that carry blood to the lungs.

 

NAC only causes this deleterious molecule in poorly oxygenated blood ie only in the pulmonary artery. PAH is seldom detected because the only way to measure the pulmonary arterial pressure is by a catheter introduced into the heart. PAH over time causes hypertrophy of the right ventricle leading to congestive heart failure, possibly over a long period of time. This is not something with which I would take chances. NAC is on my "off-limits" list until/unless there is some easier way to measure pulmonary pressure.


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#5 JR7

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Posted 27 October 2016 - 10:42 PM

Great information. Thank you both 



#6 ironfistx

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Posted 28 October 2016 - 06:47 PM

I thought the pulmonary arterial hypertension was only in animals?

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#7 RWhigham

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Posted 28 October 2016 - 09:42 PM

I thought the pulmonary arterial hypertension was only in animals?

 

Demonstrated in mice.  Not ruled out in people. Hard to rule out because heart catheterization is so invasive, expensive, and not risk free.

 

The consequences of long term PAH are devastating. I watched my dog die from this very thing, caused by a leaky left valve.

 

The supplement honokiol is reputed to prevent right ventricular hypertrophy - I wish I had known in time to give it to my dog.

 

The vet had nothing to offer.






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