Reduced expression of MYC increases longevity and enhances healthspan.
It says in article:
"MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In contrast, we find that Myc haploinsufficient (Myc+/–) mice exhibit increased lifespan.
They show resistance to several age-associated pathologies, including osteoporosis, cardiac fibrosis, and immunosenescence.
They also appear to be more active, with a higher metabolic rate and healthier lipid metabolism.
The ancestral role of MYC as a regulator of ribosome biogenesis is reflected in reduced protein translation, which is inversely correlated with longevity.
We also observe changes in nutrient and energy sensing pathways, including reduced serum IGF-1, increased AMPK activity, and decreased AKT, TOR, and S6K activities"
So what can we do, gene therapy maybe?
https://www.ncbi.nlm...pubmed/25619689
http://www.cell.com/...8674(14)01586-4