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Reducing expression of MYC

myc lifespan healthspan

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#1 Diocletian

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Posted 07 November 2016 - 04:14 PM


Reduced expression of MYC increases longevity and enhances healthspan.

 

It says in article:

"MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In contrast, we find that Myc haploinsufficient (Myc+/–) mice exhibit increased lifespan.

They show resistance to several age-associated pathologies, including osteoporosis, cardiac fibrosis, and immunosenescence.

They also appear to be more active, with a higher metabolic rate and healthier lipid metabolism.

The ancestral role of MYC as a regulator of ribosome biogenesis is reflected in reduced protein translation, which is inversely correlated with longevity.
We also observe changes in nutrient and energy sensing pathways, including reduced serum IGF-1, increased AMPK activity, and decreased AKT, TOR, and S6K activities"

 

So what can we do, gene therapy maybe?

 

https://www.ncbi.nlm...pubmed/25619689

 

http://www.cell.com/...8674(14)01586-4







Also tagged with one or more of these keywords: myc, lifespan, healthspan

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