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Micronized Resveratrol Corrects Hormone Imbalance - Human Study

resveratrol hormone study human study clinical study

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#1 Anthony_Loera

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Posted 25 November 2016 - 04:15 PM


From The Endocrine Society:

https://www.endocrin...women-with-pcos

 

Supplement lowers testosterone levels in women with common cause of infertility

 

Washington, DC - Resveratrol—a natural compound found in red wine and grapes—can help address a hormone imbalance in women with polycystic ovary syndrome (PCOS), a leading cause of infertility in women, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

 

An estimated 5 million to 6 million women in the United States have PCOS, according to the Hormone Health Network. It is one of the most common endocrine conditions in women of childbearing age.

 

Women who have PCOS produce slightly higher amounts of testosterone and other androgen hormones than average. Although these reproductive hormones are typically associated with men, women also have small amounts. The elevated levels in women with PCOS can contribute to irregular or absent menstrual periods, infertility, weight gain, acne or excess hair on the face and body. Women who have PCOS also face a higher risk of developing other health problems, such as diabetes.

 

Resveratrol is one of a group of plant compounds known as polyphenols. In addition to red wine and grapes, resveratrol is found in nuts. The compound has anti-inflammatory properties.

 

“Our study is the first clinical trial to find resveratrol significantly lowers PCOS patients’ levels of testosterone as well as dehydroepiandrosterone sulfate (DHEAS), another hormone that the body can convert into testosterone,” said the study’s senior author, Antoni J. Duleba, MD, of the University of California, San Diego in La Jolla, CA. “This nutritional supplement can help moderate the hormone imbalance that is one of the central features of PCOS.”

Thirty women with PCOS completed the randomized, double-blind, placebo-controlled trial conducted at Poznan University of Medical Sciences in Poznan, Poland. The women were randomly assigned to either take a resveratrol supplement or a placebo pill daily for three months. The participants had blood samples drawn at the beginning and end of the study to determine levels of testosterone and other androgen hormones. The women also underwent an oral glucose tolerance test at the start and conclusion of the study to measure diabetes risk factors.

 

The researchers found total testosterone levels fell by 23.1 percent among the women who received the resveratrol supplement. In comparison, testosterone levels increased 2.9 percent in the placebo group. DHEAS declined by 22.2 percent in the resveratrol group, while the placebo group experienced a 10.5 percent increase in DHEAS levels.

 

In addition to moderating androgen hormones, the women who received resveratrol showed improvement in diabetes risk factors. Among the resveratrol group, fasting insulin levels dropped by 31.8 percent during the three-month study. The researchers also found the women who received resveratrol during the study became more responsive to the hormone insulin over the course of the study.

 

“The findings suggest resveratrol can improve the body’s ability to use insulin and potentially lower the risk of developing diabetes,” Duleba said. “The supplement may be able to help reduce the risk of metabolic problems common in women with PCOS.”

 

The study, “Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial,” will be published online at http://press.endocri...10/jc.2016-1858, ahead of print.

 

Other authors of the study include: Beata Banaszewska, Joanna Wrotyńska-Barczyńska, Robert Z. Spaczynski and Leszek Pawelczyk of Poznan University of Medical Sciences in Poznan, Poland.

 

RevGenetics provided the resveratrol for the study.

For more information on PCOS, visit the Hormone Health Network’s digital toolkit.

###


Edited by Anthony_Loera, 25 November 2016 - 04:15 PM.

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#2 Heisok

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Posted 25 November 2016 - 08:16 PM

Thanks Anthony_Loera, you have been contributing great information. The Micronized Resveratrol seems like an excellent help for PCOS sufferers. My wife has indications of it.

 


Edited by Heisok, 25 November 2016 - 08:26 PM.

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#3 Examfit Nootropic Formula

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Posted 05 January 2017 - 04:36 PM

The results of these study are very, very odd. Despite being phytoestrogen - it acts like mixed agonist/antagonist on estrogen receptors - resveratrol exerts strong anti-aromatase effect on testosteron levels, meaning that test doesnt convert  into estrogen. I cannot imagine the 23% decrease of any hormone to such level - the only possible explanation I see, since it is very selectively to which ER it bonds, is that PCOS is related to different ER than usual. Resveratrol is - due to blocking of estrogen, even considered as estrogen-sensiteive-type of breast cancer drug/prevention: https://www.ncbi.nlm...pubmed/24929094 In non-scientifically terms, guys enjoying that for blocking the conversion to estrogen aka rising free T. 

PCOS is not per default excessive testosterone, it is overproduction of all hormones. Usually women with pcos have developed or originated from estrogen-dominant organism. The fall may be also due to the change of environmental factors/experimental condition which study model has implemented (carbs intake). On the other hand, 1500mg of stilbenes is a lot ;)


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#4 Heisok

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Posted 09 January 2017 - 10:10 PM

The link to the publication is in the original post. Please show within it the specifics which you have a problem with or challenge of.

 

The publication:

 

http://press.endocri...10/jc.2016-1858

 

 

The results of these study are very, very odd. Despite being phytoestrogen - it acts like mixed agonist/antagonist on estrogen receptors - resveratrol exerts strong anti-aromatase effect on testosteron levels, meaning that test doesnt convert  into estrogen. I cannot imagine the 23% decrease of any hormone to such level - the only possible explanation I see, since it is very selectively to which ER it bonds, is that PCOS is related to different ER than usual. Resveratrol is - due to blocking of estrogen, even considered as estrogen-sensiteive-type of breast cancer drug/prevention: https://www.ncbi.nlm...pubmed/24929094 In non-scientifically terms, guys enjoying that for blocking the conversion to estrogen aka rising free T. 

PCOS is not per default excessive testosterone, it is overproduction of all hormones. Usually women with pcos have developed or originated from estrogen-dominant organism. The fall may be also due to the change of environmental factors/experimental condition which study model has implemented (carbs intake). On the other hand, 1500mg of stilbenes is a lot ;)

 


 


Edited by Heisok, 09 January 2017 - 10:28 PM.

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