15 replies to this topic

[Mind_Paralysis]

Yeah, I just got to thinking about this, since reading about two peculiar antiinflammatories, namely Aprepitant and Montelukast.

 

Both have highly novel modes of effect, and does not seem to have any dramatic side-effects, as well as not being interactive with just about anything else.

 

Could there be highly effective nootropic gains to be made from these?? Well that, or a complex antidepressive action. And what other novel neuroantiinflammatories are there out there? Other than the classic antidepressants and Racetams.

 

How would a hypothetical stack of such compounds look?

 

I'm thinking something like this:

 

20 mg Montelukast

3 grams Omega-3

300 mg Aprepitant

500 mg Aspirin

 

References:

------------------

Aspirin and omega-3 fatty acids work together to fight inflammation

https://www.scienced...30221141250.htm

 

Addition of aspirin to a fish oil-rich diet decreases inflammation and atherosclerosis in ApoE-null mice.

https://www.ncbi.nlm...pubmed/27394692

 

Pharmacologic implications of inflammatory comorbidity in bipolar disorder.

https://www.ncbi.nlm...pubmed/27400335

 

The role of substance P in stress and anxiety responses.

https://www.ncbi.nlm...pubmed/16820980

 

Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis.

https://www.ncbi.nlm...pubmed/21370724

 

 

[normalizing]

interesting the combo of aspirin and omega 3s. tho 500mg of aspirin is too much and bad for the stomach. probably adding high vit c dose too to the mix might help a bit.

 

first time i hear of aprepitant and since i read it helps with major depression, im interested now i wonder how likely it is to get it prescribed...

[f099y]

I was on Montelukast for a month recently and while it worked fantastically for my allergies it quite certainly caused me some insomnia. I myself am planning on trying Ibudilast next in the hope that it may clear up some brain fog as Lostfalco has claimed it does. It also doesn't hurt that it helps for asthma and furthermore may alleviate dizziness.

 

I would use Montelukast again and for a longer period to see if any other effects start appearing, if I can afford it after I have bought all my other stuff.

[Mind_Paralysis]

Interesting! =) Ibudilast is another of those drugs that's going into my cabinet of interesting things, methinks!

 

Might it be synergistic with some of the above compounds? Could it be useful in a stack?

[normalizing]

I was on Montelukast for a month recently and while it worked fantastically for my allergies it quite certainly caused me some insomnia. I myself am planning on trying Ibudilast next in the hope that it may clear up some brain fog as Lostfalco has claimed it does. It also doesn't hurt that it helps for asthma and furthermore may alleviate dizziness.

 

I would use Montelukast again and for a longer period to see if any other effects start appearing, if I can afford it after I have bought all my other stuff.

 

ive done ibudilast and whatever side effects you got from montelukast, its likely youll get them from ibudilast as well. overall not a significantly important drug but perhaps it might benefit those with asthma
 

[f099y]

 

I was on Montelukast for a month recently and while it worked fantastically for my allergies it quite certainly caused me some insomnia. I myself am planning on trying Ibudilast next in the hope that it may clear up some brain fog as Lostfalco has claimed it does. It also doesn't hurt that it helps for asthma and furthermore may alleviate dizziness.

 

I would use Montelukast again and for a longer period to see if any other effects start appearing, if I can afford it after I have bought all my other stuff.

 

ive done ibudilast and whatever side effects you got from montelukast, its likely youll get them from ibudilast as well. overall not a significantly important drug but perhaps it might benefit those with asthma
 

 

 

Damn I've been pinning quite a lot of hope on it lately. Especially after I saw it might help with some forms of dizziness above and beyond the potential brain fog alleviation.

 

God I just don't know what is wrong with my head, this bloody dizzy, blank, foggy feeling that is almost constantly present!

 

I just hope the neurologist finds something!
 

[Blackkzeus]

I was on Montelukast for a month recently and while it worked fantastically for my allergies it quite certainly caused me some insomnia. I myself am planning on trying Ibudilast next in the hope that it may clear up some brain fog as Lostfalco has claimed it does. It also doesn't hurt that it helps for asthma and furthermore may alleviate dizziness.

I would use Montelukast again and for a longer period to see if any other effects start appearing, if I can afford it after I have bought all my other stuff.

ive done ibudilast and whatever side effects you got from montelukast, its likely youll get them from ibudilast as well. overall not a significantly important drug but perhaps it might benefit those with asthma

How was Ibudilast for cognition. ?

[jack black]

the COX-1 and COX-inhibitors are not exactly novel, but they influence both NMDA and dopamine activity.

 

http://onlinelibrary....20241/abstract

[Lia-chan]

I'm also interested in creating of antineuroinflammatory stack.

Currently I take 2400 mg of NAC and also a hell lot of vitamin C.

Years ago, I've used to take Emoxypine and somewhy it's really helped me with brain fog, I think because somekind of mechanism is also involved in modulating NMDA/Dopamine activity and I REALLY can feel it. I mean I can feel that it works, right now I use 20mg of Memantine so I really don't want it to additionally mess with my NMDA activity. I think I'm even have soon will have to lower my daily dosage of Memantine because I've again started to take Atomoxetine, so sort of adjustment is also needed.

[normalizing]

 

 

I was on Montelukast for a month recently and while it worked fantastically for my allergies it quite certainly caused me some insomnia. I myself am planning on trying Ibudilast next in the hope that it may clear up some brain fog as Lostfalco has claimed it does. It also doesn't hurt that it helps for asthma and furthermore may alleviate dizziness.

I would use Montelukast again and for a longer period to see if any other effects start appearing, if I can afford it after I have bought all my other stuff.

ive done ibudilast and whatever side effects you got from montelukast, its likely youll get them from ibudilast as well. overall not a significantly important drug but perhaps it might benefit those with asthma

How was Ibudilast for cognition. ?

 

 

hard to tell since i was mixing it with several things. i brought it together with alinamin f from japan and i used both together and separately and i found out, alinamin f was much more potent better cognitive enhancer than ibudilast. but that is personal experience of course.

 

alinamin f is https://en.wikipedia...i/Fursultiamine
 

[Mind_Paralysis]

the COX-1 and COX-inhibitors are not exactly novel, but they influence both NMDA and dopamine activity.

 

http://onlinelibrary....20241/abstract

 

Interesting! I see that my old friend KYNA - Kynurenic Acid is involved here - apparently COX/COX-1 -inhibitors somehow decrease the levels of KYNA, thereby decreasing Dopaminergic fireing... hmmm....!

 

Now THIS could be useful...! Perhaps there's a COX-inhibitor which can decrease the effects of KYNA significantly?? Would be very useful for people with Schizophrenia (directly linked to abnormally high kyna-levels - which makes sense, since KYNA is an NMDA-antagonist)

 

Perhaps this might be what I need for a potential Bipolar-stack as well! Let's have a closer look here...

[KieranA001]

I came across this thread the other day that recommended Gulantamine has some potential for brain fog, but it's really expensive. Has anyone had any experience? I have normal fish oil at home 50/50 ratio, heard it was bad to take too much EPA though but if it helps with my brain fog I might give it a go with just EPA version!

 

 

Edited by KieranA001, 07 March 2017 - 10:16 AM.

[normalizing]

i have galantamine for sell, its from the real actual source made in eastern europe and its not generic. i remember when i brought it it was kind of expensive but im willing to sell it half the price before next year's expiration date if anyone is interested

[KieranA001]

i have galantamine for sell, its from the real actual source made in eastern europe and its not generic. i remember when i brought it it was kind of expensive but im willing to sell it half the price before next year's expiration date if anyone is interested

 

What form is the galantamine in? If it's in form of pills then even better, I would be interested. If not then I will still be interested in this. 

[normalizing]

its this one i brought in eastern europe when visiting; http://daibac.com/wp...ivalin-vien.jpg

 

i think i have around 60 tablets by 5mg exactly same box but written in Cyrillic.

 

i cannot recall how much i paid for it, it was a while ago, but they were quite expensive even for the standards there. anyway, expiration date is all the way to 2020 so if you are ever interested i can sell you some if you msg me i can give you my email and i use paypal

Edited by hazy, 09 March 2017 - 03:20 AM.

[Elroy]

Has anyone tried Aprepitant? Blunting the stress response is exactly what I need.