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Phenibut as neuroprotective.

phenibut nootropic neuroprotective

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#1 Junk Master

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Posted 11 December 2016 - 04:08 AM


Found this study interesting.  From Feb of this year.

 

Bull Exp Biol Med. 2016 Feb;160(4):465-9. doi: 10.1007/s10517-016-3198-4. Epub 2016 Feb 23.
Comparison of Nootropic and Neuroprotective Features of Aryl-Substituted Analogs of Gamma-Aminobutyric Acid.
Abstract

GABA analogs containing phenyl (phenibut) or para-chlorophenyl (baclofen) substituents demonstrated nootropic activity in a dose of 20 mg/kg: they improved passive avoidance conditioning, decelerated its natural extinction, and exerted antiamnestic effect on the models of amnesia provoked by scopolamine or electroshock. Tolyl-containing GABA analog (tolibut, 20 mg/kg) exhibited antiamnestic activity only on the model of electroshock-induced amnesia. Baclofen and, to a lesser extent, tolibut alleviated seizures provoked by electroshock, i.e. both agents exerted anticonvulsant effect. All examined GABA aryl derivatives demonstrated neuroprotective properties on the maximum electroshock model: they shortened the duration of coma and shortened the period of spontaneous motor activity recovery. In addition, these agents decreased the severity of passive avoidance amnesia and behavioral deficit in the open field test in rats exposed to electroshock. The greatest neuroprotective properties were exhibited by phenyl-containing GABA analog phenibut.

KEYWORDS:

GABA; baclofen; nootropic and neuroprotective properties; phenibut; tolibut

 
 


#2 infectedcalf

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Posted 11 December 2016 - 04:51 AM

Very surprised. Phenibut is the femme fatale of nootropic drugs in my world.

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#3 Junk Master

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Posted 12 December 2016 - 03:56 AM

Thought this would surprise a lot of people as it surprised me.



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#4 stan08

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Posted 23 December 2016 - 11:05 AM

Thought this would surprise a lot of people as it surprised me.


Thanks for posting. Kinda surprised more aren't commenting on this article. There's so much negative posted about phenibut on here (likely due to most not having the discipline to use it responsibly), that somethimg positive should really stand out.





Also tagged with one or more of these keywords: phenibut, nootropic, neuroprotective

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