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supplements with "anti- choligenic" activity to reduce mild tinnitus?

tinnitus anticholigenic

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6 replies to this topic

#1 cylon

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Posted 18 December 2016 - 09:14 PM


Hi

I'm a middle aged male in otherwise great health but am increasingly paranoid about anything I might use that might exacerbate a currently tolerable case of tinnitus.

(ie if I don't think about it it doesn't bother me:)

Much online research I've done point to supplements which act as acetylcholinesterase inhibitors(increasing acetyl choline levels) can also be linked to some types of tinnitus.

I've stopped taking anything containing Huperzine A for this reason.

 

My 3x weekly regimen

-Krill oil 600-1200mg

-Ubiquinol 100mg

-Turmeric 400mg

-Curcumin (Longvida) 400mg

-Rhodiola 100 mg

-Cordyceps 200 mg

-Pycnogenol 75mg

-LicoriceRoot-100mg

 

-Ashwaganda 280mg

 

Over on Examine.com they also list Curcumin as a acetylcholine inhibitor. Should I stop taking it as well?

Are there any other supplements that might complement my stack but have an "anti-choligenic" effect to reduce acetylcholine build up?

 


Edited by cylon, 18 December 2016 - 09:24 PM.


#2 timar

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Posted 19 December 2016 - 03:33 PM

For how long do you have your tinitus and did it develop spontanously or from being exposed to an acoustic stressor?



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#3 cherrysilver

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Posted 12 January 2017 - 01:50 PM

I have exactly the same problem -- mine was caused by prescription NSAID usage over 20 years ago.  While it is tolerable (and annoying), I've noticed that its gotten slightly worse over the past few years.  Any ideas or suggestions for how to minimize this would be most appreciated!



#4 Matt

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Posted 22 January 2017 - 07:25 PM

I've had tinnitus since around 2005.. The only time it's increased was when I got a perforated eardrum a few weeks ago. Fortunately even though it was large, it is healing well and tinnitus has mostly gone back to normal levels (very low and barely noticeable 99% of the time).

 

I've not really found anything that reduces the noise, but it seems like those supplements will help yours from getting worse.

I'd add EGCG to that, and quercetin. Both have been shown to prevent damage to hearing from medications and noise exposure.


Edited by Matt, 22 January 2017 - 07:26 PM.


#5 nickdino

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Posted 27 February 2017 - 12:10 AM

Where is the proof for that matt?

#6 Matt

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Posted 27 February 2017 - 02:09 PM

Quercetin protects against hair cell loss in the zebrafish lateral line and guinea pig cochlea.

https://www.ncbi.nlm...pubmed/27717895

 

Quercetine attenuates the gentamicin-induced ototoxicity in a rat model.

https://www.ncbi.nlm...pubmed/26434546

 

Effects of epigallocatechin-3-gallate on proliferation and differentiation of mouse cochlear neural stem cells: Involvement of PI3K/Akt signaling pathway.

https://www.ncbi.nlm...pubmed/27012759

 

Green Tea Polyphenols Protects Cochlear Hair Cells from Ototoxicity by Inhibiting Notch Signalling.

https://www.ncbi.nlm...pubmed/25896296

 

(-)-Epigallocatechin-3-Gallate Protects against NO-Induced Ototoxicity through the Regulation of Caspase- 1, Caspase-3, and NF-κB Activation

http://journals.plos...al.pone.0043967

 

And then, even combination of supplements Vitamin A, C, E, and Magneisum helps reduce noise trauma.

https://www.ncbi.nlm...les/PMC1950331/

 

 

From what I understand, it is thought that tinnitus may start in the innear ear and then the brain stops filtering out this sound and it's no longer a case of just fixing the inner ear problem. That being said, temporary spikes from eustachian tube dysfunction and/or perforated ear drum may completely resolve once healed and T go back to normal. I was hopeful for AM-101? (I think that was its name), but apparently it wasn't a miracle cure for everyone.

 



#7 Duchykins

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Posted 12 March 2017 - 07:26 AM

Ditch the krill oil, rhodiola, ashwaganda and curcumin


Edited by Duchykins, 12 March 2017 - 07:27 AM.






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