didnt know where else to put this its not really related to other forums but it seems to fit here.
so to begin, im confused about all those studies that asses max toxicity levels in rats and other animals. it always says mg per kg and i cannot possible figure out how to calculate this to how much exactly mgs are used in the study. it has been confusing me for a long time too and i just have to ask and if not the proper place to do so i apologize.
here is an example of my confusion; https://www.ncbi.nlm...pubmed/11434987
"Because of pathological changes in male liver and hematological changes in females, the no-observed-adverse-effect level (NOAEL) was concluded to be 0.19% in the diet (120 mg/kg body weight/day for male rats and 130 mg/kg body weight/day for female rats)"
so what does 120mg/kg body means?? and what is the no observed adverse effect level mean? so it doesnt cause adverse effects, YET, it just mentions it DOES cause them! very confused!
here is how it ends; As a decrease in MCV, an increase in the A/G, elevation of alkaline phosphatase and increase in adrenal weight were observed in all treated males, a no-observed-effect level (NOEL) could not be determined in this examination.
ok, so they say adverse effects could be determined at the end, but they just did in the study and did find liver changes! so i dont get it.
anyway, main problem is, what program to use to calculate this 120mg/kg thing, PLEASE HELP!!!