2 replies to this topic

[trying2survive]

Hi experts,

I hope this is not a dumb question.

I'm interested in upping Parkin especially after this recent article http://www.technolog...ck-aging-clock/

But instead of taking a drug like Nilotinib, why not take the protein directly(injection) from a protein company ex.

http://www.bostonbio...d5NURoC-SXw_wcB

(other than it appears expensive {though I believe the qtys needed are extremely small} )?

 

What am I missing?

Thanks!

[trying2survive]

same question goes for proteins we'd like to suppress...

can we just inject antibodies like http://www.biolegend...ibody-8806.html

and have our immune system remove them?

any advice?

 

[Darryl]

WRT Parkin, it wouldn't get past the blood brain barrier.

 

In animal experiments, its possible to do transcranial injections into local structures, but in general the blood-brain barrier prevents anything larger than a small polypeptides through. A very few centrally acting peptide hormones (eg, adiponectin, leptin, etc) may be able to pass the BBB through specific adaptations, but levels in cerebrospinal fluid a still a 1000-fold lower than in serum.

 

So, most of the hope for increasing cerebral gene expression is through genetic therapy with targetted adenoviruses, etc, at the moment.