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anti aging supplements regimen protocol

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#1 JR7

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Posted 04 January 2017 - 10:21 PM


Here is my current supplement list with the hopeful goals of anti-aging, athletic performance increase or maintenance, and physique aesthetic improvements. Are there supplements Im missing or using unnecessarily? 

Thank you 

 

 

  1. Omega 3 with Sesame Lignans, Olive Extract, Krill & Astaxanthin - https://www.amazon.com/gp/product/B00JPD5ZJ4/ref=oh_aui_search_detailpage?ie=UTF8&th=1
  2. Garlic - https://www.amazon.com/gp/product/B00OYK3MMA/ref=oh_aui_search_detailpage?ie=UTF8&psc=1
  3. Magnesium (L-Threonate) - https://www.amazon.com/gp/product/B01M4GM9R1/ref=oh_aui_search_detailpage?ie=UTF8&psc=1
  4. Vitamins K2 & D3 - https://www.amazon.com/gp/product/B01GGFDVUI/ref=oh_aui_search_detailpage?ie=UTF8&psc=1
  5. Resveratrol - https://www.amazon.com/gp/product/B013GVCD6I/ref=oh_aui_search_detailpage?ie=UTF8&psc=1
  6. Green Tea - https://www.amazon.com/dp/B013XKP3TG?ref_=ams_ad_dp_asin_img
  7. Sulforaphane - https://www.amazon.com/gp/product/B0013OVTM0/ref=oh_aui_detailpage_o04_s00?ie=UTF8&th=1
  8. Curcumin - https://www.amazon.com/gp/product/B00CAYNWY0/ref=oh_aui_search_detailpage?ie=UTF8&th=1
  9. Pomegranate - https://www.amazon.com/gp/product/B019ZFQMHK/ref=oh_aui_search_detailpage?ie=UTF8&th=1
  10. Alpha Lipoic Acid - https://www.amazon.com/gp/product/B0013OXBH6/ref=oh_aui_detailpage_o04_s00?ie=UTF8&th=1
  11. Nicotinamide Riboside - https://www.amazon.com/gp/product/B00NPXDXNA/ref=oh_aui_search_detailpage?ie=UTF8&psc=1 

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#2 RWhigham

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Posted 05 January 2017 - 02:43 AM

Very nice!

You might want to consider better absorbing curcumin and resveratrol:

  • Enhanced delivery curcumin Meriva®, Longvida®, BCM-95®, and Theracurmin® have been around awhile. The latest enhancement is UltraCur® which greatly improves the amount of unchanged curcumin reaching plasma compared to the others.
  • Micronized resveratrol from MegaResveratrol has 500mg/capsule of 99% pure trans-resveratrol and micronizing gives 3.6x the plasma level of non micronized resveratrol. Your referenced resveratrol with 50% trans-resveratrol is $1.33/g trans-resveratrol vs $1.55/g for MegaResveratrol. The latter is 16.5% more expensive but 360% more effective.

Garlic: There are two types of garlic supplements - AGED Garlic, and extracts that provide allicin. I like Garlicin cardio for the latter. "AGED" Garlic provides compounds different from plain garlic powder, and is reported to be much better for many things (tau aggregation and atherosclerosis). The garlic you referenced does not appear to excel in either category.

 

Pomegranate:  A main pomegranate benefit recently reported is from the ellagic acid content getting converted to urolithin-a by gordonibacter urolithinfaciens. It only works if you are lucky enough to have this or an equivalent bacteria in your gut. Raw walnuts have a much higher content of ellagic acid than pomegranate. So, if your are lucky, you will get even more urolithin-a from eating raw walnuts than from pomegranate. If you are not lucky, the benefits of ellagic acid are uncertain.

 

Magnesium L-Threonate:  The supplement in your reference contains 25 servings of 2 g  -> 50 g for $25, or 0.50/g.  Source Naturals Magstein has 60 servings at 2 g -> 120 g for $39 (0.32/g). Same stuff except for the excipients. Yours has nicer excipients. 180 capsules of Magstein is cheaper.

 

Green Tea extract:  It's risky to exceed the recommended dose.


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#3 Dorian Grey

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Posted 05 January 2017 - 03:22 AM

Sweet lookin' stack.  Any time you're taking fish oil (the Omega 3) you want to make sure you're getting enough dietary or supplemental Vitamin-E, as fish oil is highly oxidizable.  Natural E with mixed tocopherols is best.  I've found low dose 200 IU gelcaps are available, and I prefer these to the standard/typical 400 IU dose.  More is not always better!  By combining E with the Omega 3's, you'll keep it from oxidizing in the body and may use lower doses of the Omega 3's, which I would also recommend.  


Edited by synesthesia, 05 January 2017 - 03:28 AM.

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#4 JR7

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Posted 05 January 2017 - 03:51 AM

Very nice!

You might want to consider better absorbing curcumin and resveratrol:

  • Enhanced delivery curcumin Meriva®, Longvida®, BCM-95®, and Theracurmin® have been around awhile. The latest enhancement is UltraCur® which greatly improves the amount of unchanged curcumin reaching plasma compared to the others.
  • Micronized resveratrol from MegaResveratrol has 500mg/capsule of 99% pure trans-resveratrol and micronizing gives 3.6x the plasma level of non micronized resveratrol. Your referenced resveratrol with 50% trans-resveratrol is $1.33/g trans-resveratrol vs $1.55/g for MegaResveratrol. The latter is 16.5% more expensive but 360% more effective.

Garlic: There are two types of garlic supplements - AGED Garlic, and extracts that provide allicin. I like Garlicin cardio for the latter. "AGED" Garlic provides compounds different from plain garlic powder, and is reported to be much better for many things (tau aggregation and atherosclerosis). The garlic you referenced does not appear to excel in either category.

 

Pomegranate:  A main pomegranate benefit recently reported is from the ellagic acid content getting converted to urolithin-a by gordonibacter urolithinfaciens. It only works if you are lucky enough to have this or an equivalent bacteria in your gut. Raw walnuts have a much higher content of ellagic acid than pomegranate. So, if your are lucky, you will get even more urolithin-a from eating raw walnuts than from pomegranate. If you are not lucky, the benefits of ellagic acid are uncertain.

 

Magnesium L-Threonate:  The supplement in your reference contains 25 servings of 2 g  -> 50 g for $25, or 0.50/g.  Source Naturals Magstein has 60 servings at 2 g -> 120 g for $39 (0.32/g). Same stuff except for the excipients. Yours has nicer excipients. 180 capsules of Magstein is cheaper.

 

Green Tea extract:  It's risky to exceed the recommended dose.

 

This is EXACTLY the feedback I was looking for. Thank you. Looking at that UltraCur, it looks remarkable but man it's expensive. I'll definitely give it a go. Are there any supplements you would remove OR add from my list? 

 

 

Sweet lookin' stack.  Any time you're taking fish oil (the Omega 3) you want to make sure you're getting enough dietary or supplemental Vitamin-E, as fish oil is highly oxidizable.  Natural E with mixed tocopherols is best.  I've found low dose 200 IU gelcaps are available, and I prefer these to the standard/typical 400 IU dose.  More is not always better!  By combining E with the Omega 3's, you'll keep it from oxidizing in the body and may use lower doses of the Omega 3's, which I would also recommend.  

 

Going forward, I will try to make sure Im getting sufficient dietary Vitamin E. Thank you for your feedback! 



#5 RWhigham

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Posted 05 January 2017 - 06:09 AM

 Are there any supplements you would remove OR add from my list?

Consider these:


Edited by RWhigham, 05 January 2017 - 06:26 AM.

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#6 RWhigham

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Posted 05 January 2017 - 04:03 PM

  1. Alpha Lipoic Acid - https://www.amazon.c...00?ie=UTF8&th=1

Alpha Lipoic Acid (ALA) is often combined with acetyl l carnitine (ALCAR). The combination was recommended many years ago by Dr Bruce Ames when his research showed it slows the aging of mitochondria. He started a company, Juvenon, and patented the combination. People often take both separately to get around the Juvenon patent and price.  http://bruceames.org...r Interview.pdf  

 

Carnosine + ALCAR is recommended for anti-aging by Jon Barron https://jonbarron.or...ing/end-old-age  Current pictures of Dr Bruce Ames and Jon Barron convince me that Jon's biological age subcedes his chronological age better than Bruce's does.

 

I cannot take ALA, because I take L-thyroxine which is pure T4. ALA inhibits the conversion of T4 to the more active form T3. If there are any indications of hypothyroidism, ALA should be avoided.

 

Dr Broda O. Barnes MD wrote a book back in the 1970's where he says chronic heart disease (CHD) is caused by unsuspected hypothyroidism. He came to that conclusion because, in his practice, he made sure all his patients had adequate thyroid hormones, and non of his patients developed CHD.  https://www.amazon.c...s/dp/069001029X


Edited by RWhigham, 05 January 2017 - 04:52 PM.

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#7 tintinet

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Posted 06 January 2017 - 01:23 AM

What of the racemic vs. R forms of ALA?

#8 Skyguy2005

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Posted 06 January 2017 - 02:01 PM


 

I cannot take ALA, because I take L-thyroxine which is pure T4. ALA inhibits the conversion of T4 to the more active form T3. If there are any indications of hypothyroidism, ALA should be avoided.

 

Dr Broda O. Barnes MD wrote a book back in the 1970's where he says chronic heart disease (CHD) is caused by unsuspected hypothyroidism. He came to that conclusion because, in his practice, he made sure all his patients had adequate thyroid hormones, and non of his patients developed CHD.  https://www.amazon.c...s/dp/069001029X

 

 

Is it true that hypothyroidism is associated with longevity? My mother has hypothyroidism and I wonder whether it would be better to not take meds for "correcting" it.

 

https://www.ncbi.nlm...les/PMC4480281/ ( "The findings obtained in the Leiden Longevity Study actually show the associations between low thyroid activity and exceptional familial longevity [11].Also in animals, a reduced thyroid function with low levels of T4 seems to be associated with extended longevity [12-14]")


Edited by Skyguy2005, 06 January 2017 - 02:05 PM.

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#9 Oakman

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Posted 06 January 2017 - 03:09 PM

 

 Are there any supplements you would remove OR add from my list? 

 

 

Here are a few additional to consider....

 

LE AMPK Activator - enhanced version of what RWhigham mentioned

Apigenin - flavonoid with antioxident anti,-inflammatory, and anti-tumor properties -  info

Pterostilbene - 150mg take with NR, give something similar to Elysium BASIS  

Cool Cayenne - capsicum 100,000 units  - info

EnduraQ - EMIQ bioavailable quercetin

Robuvit - precursor to urolithins thru gut production

SOD Gliadin Complex - enhance your body's own antioxident system w/bioavailable biosimilar compounds

Vitamin K Triple Play - balance for other supplements that act as blood thinners

UtraBroc - advanced curcumin (UltraCur) w/Sulforaphane - no need to buy these separately

Phosphatidyl-serine  - info

Mitochondrial Energy Optimizer w/BioPQQ - combo Carnosine, L-Taurine, Benfortiamine, R-Lipoic Acid, BipPQQ, Luteolin, B6


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#10 RWhigham

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Posted 07 January 2017 - 12:32 AM

Is it true that hypothyroidism is associated with longevity?

Your link https://www.ncbi.nlm...les/PMC4480281/ questions the advisability of treating subclinical hypothroidism in the elderly. They refer to studies that found no benefit, then the association between Ashkenazi Jewish centenarians and slightly underactive thyroid is cited as additional justification. Not sure this is a great argumentWhile there is an unusual number of centenarians, about 1 in 4 carries a severe genetic disease. This article is telling the medical community they need not feel bad about ignoring subclinical hypothyroidism, in stark contrast to Dr Broda Barnes and others.

 


Edited by RWhigham, 07 January 2017 - 12:35 AM.


#11 JR7

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Posted 08 January 2017 - 03:01 AM

 

 Are there any supplements you would remove OR add from my list?

Consider these:

 

Cant thank you enough for this thought out list. 



#12 JR7

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Posted 08 January 2017 - 03:05 AM

 

  1. Alpha Lipoic Acid - https://www.amazon.c...00?ie=UTF8&th=1

Alpha Lipoic Acid (ALA) is often combined with acetyl l carnitine (ALCAR). The combination was recommended many years ago by Dr Bruce Ames when his research showed it slows the aging of mitochondria. He started a company, Juvenon, and patented the combination. People often take both separately to get around the Juvenon patent and price.  http://bruceames.org...r Interview.pdf  

 

Carnosine + ALCAR is recommended for anti-aging by Jon Barron https://jonbarron.or...ing/end-old-age  Current pictures of Dr Bruce Ames and Jon Barron convince me that Jon's biological age subcedes his chronological age better than Bruce's does.

 

I cannot take ALA, because I take L-thyroxine which is pure T4. ALA inhibits the conversion of T4 to the more active form T3. If there are any indications of hypothyroidism, ALA should be avoided.

 

Dr Broda O. Barnes MD wrote a book back in the 1970's where he says chronic heart disease (CHD) is caused by unsuspected hypothyroidism. He came to that conclusion because, in his practice, he made sure all his patients had adequate thyroid hormones, and non of his patients developed CHD.  https://www.amazon.c...s/dp/069001029X

 

Well....this is good to know. I take 0.1mg of synthroid everyday. Going off what you're saying, I should discontinue supplementing ALA


 

Here are a few additional to consider....

 

LE AMPK Activator - enhanced version of what RWhigham mentioned

Apigenin - flavonoid with antioxident anti,-inflammatory, and anti-tumor properties -  info

Pterostilbene - 150mg take with NR, give something similar to Elysium BASIS  

Cool Cayenne - capsicum 100,000 units  - info

EnduraQ - EMIQ bioavailable quercetin

Robuvit - precursor to urolithins thru gut production

SOD Gliadin Complex - enhance your body's own antioxident system w/bioavailable biosimilar compounds

Vitamin K Triple Play - balance for other supplements that act as blood thinners

UtraBroc - advanced curcumin (UltraCur) w/Sulforaphane - no need to buy these separately

Phosphatidyl-serine  - info

Mitochondrial Energy Optimizer w/BioPQQ - combo Carnosine, L-Taurine, Benfortiamine, R-Lipoic Acid, BipPQQ, Luteolin, B6

 

Thank you for this list. I'm going to research each one later tonight. 

Do you see any issue with the Sulforaphane I've listed? 


Edited by JR7, 08 January 2017 - 03:15 AM.


#13 JR7

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Posted 08 January 2017 - 03:18 AM

So far, Ive received excellent input to add to my list. With that, is there a general consensus on how often I should cycle on/off the supplements, if at all? Are there some that require no cycling? 

Thank you 



#14 pamojja

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Posted 08 January 2017 - 12:42 PM

Consider these:

 

What is your reason for generally recommending manganese, without indications from lab-work of deficiency? Since it's already so plenty from diet, by which for example I get already about 10mg daily.

 

 

https://selfhacked.c...es/#3_Manganese

 



#15 RWhigham

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Posted 08 January 2017 - 05:43 PM

What is your reason for generally recommending manganese, without indications from lab-work of deficiency? Since it's already so plenty from diet, by which for example I get already about 10mg daily.

pamojja, I'm glad you pointed that out. My recommendation for 1/4 tablet of manganese, 2.5mg, was for "adequate intake" of 2.3 mg. I still had this in my stack from less informed days. I'm tossing it. Thanks

 


Edited by RWhigham, 08 January 2017 - 06:31 PM.


#16 RWhigham

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Posted 08 January 2017 - 06:43 PM

So far, I've received excellent input to add to my list. With that, is there a general consensus on how often I should cycle on/off the supplements, if at all? Are there some that require no cycling? 

Nothing in my list need to be cycled, except perhaps ActivAMP. It's new in my stack, and I need to study it more.

 

C60-EVOO may need to be discontinued after a few years. C60 may build up in the body and stay there: http://www.longecity...esearch-update/  But my wife and I have taken it for 2 years and are not ready to stop.


Edited by RWhigham, 08 January 2017 - 07:19 PM.


#17 RWhigham

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Posted 22 January 2017 - 12:55 AM

Nothing in my list need to be cycled, except perhaps ActivAMP. It's new in my stack, and I need to study it more.

ActivAMP is a potent AMPK activator.  AMPK is the "energy depletion" sensor that gets turned on by fasting. It should inhibit cells from growing and dividing, and increase the clearance of junk proteins, excess and damaged organelles, lipid droplets, and other garbage. Fasting inhibits muscle growth, new brain cells, heart cells, etc.

 

It seems to me that ActivAMP is a fasting mimetic, and should be consumed accordingly.  Does anyone know the optimum duration and frequency for fasting?

 

 


Edited by RWhigham, 22 January 2017 - 12:55 AM.

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#18 JR7

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Posted 22 January 2017 - 01:04 AM

 

Nothing in my list need to be cycled, except perhaps ActivAMP. It's new in my stack, and I need to study it more.

ActivAMP is a potent AMPK activator.  AMPK is the "energy depletion" sensor that gets turned on by fasting. It should inhibit cells from growing and dividing, and increase the clearance of junk proteins, excess and damaged organelles, lipid droplets, and other garbage. Fasting inhibits muscle growth, new brain cells, heart cells, etc.

 

It seems to me that ActivAMP is a fasting mimetic, and should be consumed accordingly.  Does anyone know the optimum duration and frequency for fasting?

 

 

I believe Dr Rhonda Patrick talks about 3 consecutive days per month to elicit autophagy 



#19 JR7

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Posted 17 February 2017 - 10:22 PM

In the long run, Im trying to streamline this protocol to save on costs. What would be the bare essentials in folks' opinions? 



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#20 Quattro64

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Posted 25 December 2017 - 06:55 PM

Glisodin SOD  for sod1

 

NMN for sirtuins

 

ALA(RLA?) for fgf21

 

pqq, pterostilbene for mito genesis and sod2, sirt1

 

berberine instead of metformin for ampk

 

quertecin, manganese for sod2

 

k2/d3 

 

epitalon stack: glu/ala/gly/asp twice per week on empty stomach for telomerase

 

for general health and anti ageing this would be my minimum protocol.  Also I did take c60 for a while but now I'd like to wait and see if any more info comes out before I dive back in.

 

Merry Christmas!

 

 


Edited by Quattro64, 25 December 2017 - 07:24 PM.






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