Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease
https://www.ncbi.nlm...les/PMC2916709/
In this study antioxidants (NAC and vitamin E) were shown to attentuate Rapamycin and Trehalose induced rescue of several rogue-protein-type diseases. This apparently is due to inhibited autophagy.
"Neurodegeneration was reversed to control level when the Q120 flies were treated with 500 mg/ml NAC or 100 µm cystamine combined with 2 µm rapamycin" -- study
However, would such an effect be seen in people taking 600mg/day? (Which is quite a lot!)
Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance.
https://www.ncbi.nlm...pubmed/23154184
In this study 0.5% (by weight) NAC attenuated methionine restriction mediated leanness.
If someone took 500mg NAC daily, that would be 0.5% of 100g, right? Most people would eat a lot more than that, maybe 10-20x as much, or something like that.
I suppose my question is, would NAC taken at a typical low dose have any effect on beneficial effects of resveratrol, rapamycin (autophagy inducers)? Or is it just the high doses used in these studies?
Edited by Skyguy2005, 10 January 2017 - 02:44 PM.
