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[xatu01]

ANA-12 produces rapid antidepressant- and anxiolytic-like effects in animal models,^[1] the former of which have been elucidated to be mediated by blockade of BDNF signaling in the nucleus accumbens.^[2][3] It has also been found to alleviate methamphetamine-induced depression-like behavior (including anhedonia), behavioral sensitization, and nucleus accumbens neuroplasticity changes with subchronic (14-day) administration in mice, whereas the TrkB agonist 7,8-dihydroxyflavone was ineffective in doing so.^[4]

ANA-12 blocks the cognitive-enhancing effects of environmental enrichment and calorie restriction in rodents, which are mediated by BDNF signaling through TrkB in the hippocampus.^[5][6] It also blocks hippocampal neurogenesis induced by physical exercise in rodents, and may block the cognitive-enhancing effects of exercise as well.^[7]

 

^{What do you guys think about it ?}

 

^{http://www.nature.co...ll/nrd3470.html}

[Mind_Paralysis]

What I think? It sounds god-awful, is what I think!

Seriously? Impaired BDNF-signalling? Impaired-neuroplasticity? Impaired effects of *exercise*?!

 

Da' fug', man...!

 

 

This honestly sounds waaay, WAY too experimental for me! We have known for litterally EONS that exercise has a positive effect on ones cognition and mood - why would we risk taking a drug which f***'s with that??

 

No, honestly, this can't possibly be the answer...

 

Well... Wait, ok, I suppose there's something to it helping with the anhedonia caused by methamphetamine - if it can help the people foolish enough to play with such dangerous compounds, then it might have some use in the medical treatment of Meth-overdose, for instance.

 

Still, I see very limited use of this compound.