4 replies to this topic

[StephCThomp]

The below studies are the most exciting anti-aging news I have read in years. It might just be the beginning of the end to superficial aging...

 

In extreme summary, there are two (out of many) Bone Morphogenetic Proteins of interest. It seems that:

BMP2 = bad

BMP4 = great

 

In a UVA wrinkling mouse study, applying a BMP2 inhibitor "exhibited an anti-wrinkle effect which was 6-fold greater than that of retinoic acid".

https://www.ncbi.nlm...les/PMC4133875/

 

In a culture-based scarring study published a few days ago, enhancing the growth of hair follicles and subsequent BMP4 signalling from those follicles caused new adipocytes (fat cells) to regenerate from myofibroblasts. The regeneration was so effective that months post-injury scars were barely visible. This second study is fascinating because it has amazing potential for regenerating the subcutaneous fat lost with aging. That's the sticking point for many who have achieved good collagen quality and quantity, but still show their age due to fat loss. 

https://www.pennmedi...l-without-scars

 

It's probably a gross over-simplification, but now I am very interested in factors that might increase the expression of BMP4 in the skin - measures that rejuvenation hobbyists can take. What about BMP2 inhibition?  What exerts that effect?  Does anyone have knowledge about these things?

 

By implication, the studies also reinforce the importance of actively supporting hair follicle health.  

 

 

 

 

Edited by StephCThomp, 11 January 2017 - 12:53 AM.

[zorba990]

Vitamin K2 ?

https://www.ncbi.nlm...pubmed/18234293

"
INTRODUCTION:
The transformation of smooth muscle cells (VSMCs) in the vessel wall to osteoblast like cells is known to precede arterial calcification which may cause bleeding complications. The vitamin K-dependent protein MGP has been identified as an inhibitor of this process by binding BMP-2, a growth factor known to trigger the transformation"

I'm going to give high dose topical k2 a try and see...

[JR7]

Very interesting. Following this topic to hear more. Thank you for posting! 

[Logic]

I'm dumping research links here for later. Maybe someone else will find them of interest.

chrome-extension://oemmndcbldboiebfnladdacbdfmadadm/http://pubmedcentral...c00060-0065.pdf
http://www.longecity...ndpost&p=342681

Resv ups BMP2.  In-vivo or vitro?

http://www.longecity...ndpost&p=342647
http://onlinelibrary...02/jbmr.21/full

Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells
https://stemcellres....3287-016-0366-4

 

http://onlinelibrary...02/jbmr.21/full

 

https://www.ncbi.nlm...les/PMC3060402/

[MikeGreo]

Hi,

 

Recently came across the news article talking about this. http://www.independe...h-a7517056.html

 

The question is now, can we get a natural supplement to achieve these effects?

 

I have also read conflicted and confusing things regarding the different BMP types like BMP2, BMP4, BMP7. Will it cause hair loss or hair regrowth in addition to the skin rejuvenation.

 

Also check this supplement out and tell me what you think. https://www.predator...vomuse/bmp.html

 

Also if you read the science below it, there is a lot of information there.

 

Regards,

 

Mike