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Schisandra Chinensis the Tastiest Herbal Adaptogen

schisandra adaptogen herbal medicine chinese medicine sex hepatoprotective skin mitochondria

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#1 jroseland

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Posted 27 January 2017 - 08:10 PM


A delicious five flavored Adaptogen that has been used for thousands of years to Biohack Yin and Yang.
 
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A notable herbal cofactor that enables the body to process other supplements and drugs.

 

This article is mostly going to focus on finding parallels between Traditional Chinese Medicine and what more recent research is saying about Schisandra and how this squares up with the self experimentation reports coming out of the Biohacking community online. For more of my own personal experiences, thoughts and comparisons please see the written and video reviews in the sidebar.

 
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Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva.

When it comes to Schisandra Chinensis research, the 800-pound gorilla in the room is an Armenian placebo controlled, double blind study of the stress responses of 71 athletes. From it’s abstract:
“These results correlate with an increased physical performance in athletes taking adaptogens versus athletes taking placebo. In contrast after treatment with the adaptogen heavy physical exercise does not increase salivary [nitric oxide] and cortisol in athletes, whereas athletes treated with placebo heavy physical exercise increased salivary [nitric oxide].”

 

Athletic Performance

Schisandra is a hardcore athletic Biohack as it increases circulating Nitric Oxide in the blood. Nitric Oxide has been called the “master signaling molecule” that optimizes cardiovascular function.

It’s popular with joggers and anecdotally potentiates runner’s high, the flowstate induced by extended endurance exercise. Author Steven Kotler, talks about the hippie speedball, which is a cocktail of marijuana, espresso and jogging for getting into a really sublime flowstate. I’ve videoblogged about getting into really profound flowstates after combining marijuana with Heart Rate Variability training.

So when I get back to Colorado, I will self experiment with an adaptogenic hippie speedball by adding Schisandra. I bet it will be pretty rad!

The Plant

Is native to Central China and Eastern Russia, it’s a vine that grows up around trees.

 

Traditional Chinese Medicine
 
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Also referred to as Chinese Magnolia Vine, on the Traditional Chinese Medicine spectrum it’s a ‘Qi-Invigorating’ agent in the Yang family of herbs because of it’s potent anti-fatigue effects.
Schisandra berries themselves (Wu Wei Zi as it’s referred to in China) have 5 distinct tastes supposedly; salty, sweet, sour, pungent and bitter.

 
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As you can imagine, there’s some debate online as to whether the Schisandra berry contains more Nootropic qualities than extracts of it’s bioactive agents, whether the whole is greater than it’s parts.

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It’s a Tonic, which I was at first a little confused by, a tonic in Chinese Medicine is nothing like the tonic water you order at a cafe or mix with gin in your cocktail, it’s a rather wide category of herbs that have been used historically to energize different dimensions of the human experience.

In Chinese medicine there are two categories of Qi tonics; Yin and Yang
Yin — Parasympathetic nervous system
Yang — Sympathetic nervous system
Schisandra is a full spectrum tonic herb that…

Enters all 12 meridians

 
0*r03YfamsraT6Bw2Z.jpg
  • Lung (肺)
  • Heart (心)
  • Pericardium (心包)
  • Triple Burner (三焦)
  • Small Intestine (小肠)
  • Large Intestine (大腸)
  • Spleen (脾)
  • Kidney (腎)
  • Liver (肝)
  • Gall Bladder (膽)
  • Urinary bladder (膀胱)
  • Stomach (胃)

The Main Meridians Channels

Daily Course of 12 Main Meridians with Related Organs

 
0*Idvl_ez-1hHRxTC0.jpg

Nurtures all 5 elements

  • Heart
  • Digestion
  • Lungs
  • Kidneys
  • Liver

5 Elements in Nature and the Body

Tonifies all 3 treasures in Traditional Chinese Medicine

  • Qi (Body)
  • Jing (Mind)
  • Shen (Spirit)
100 Days of Schisandra

Schisandra has a cumulative effect and some authors (who were perhaps reincarnated as Internet Marketers) of some of the seminal texts of Traditional Chinese Medicine recommended taking Schisandra for 100 days straight.
This seems to be an antidote to anhedonia; it turns up the volume on reality, it turns up the brightness on existence, it puts life in high definition. To quote one herbal enthusiast:
“ive been doing these tonics pretty heavily for the past few years and i have seen pretty dramatic results… i feel as tho i am getting my jing back. like in taoism they speak of returning to being like a child… i feel like this is happening with my health and vitality. the herbs really work, but the more you work on yourself, the more they work with you.”

An Energizing Nootropic

As an adaptogen it modulates the hormones up and down, so sometimes it will make you more energetic and sometimes it will make you more relaxed and tranquil. It makes you nervous system more permeable in it’s responses.
A herbal enthusiast, Thorsten2, on Longecity
“Schizandra is best taken chronically and will enhance sleep, libido (to some extent), wellbeing/mood and cognitition (to some extent). All in all it just feels brain healthy and if you can handle Rhodiola with it, awesome.”
Thorsten2 went on to say…:
“Shizandra is supposed to enhance sleep and it did for me even after chronic use. I never noticed anything fatiguing about it or particularly energy enhancing…”
As a stimulant you are going to want to go easy on the dosage, there’s some anecdotal reports of mania and insomnia likely resulting excessive consumption.
Another experienced self experimenter on Longecity reported:
“Restless. Need to keep moving. Don’t care about little mistakes, but am quite accurate with my thoughts and movements. Looks like 300mg is all I need. That extra 100mg afterwards was a little overkill. Blood pressure and pulse are a little high, but not of concern.”
Some online have reservations about the potent Schizandriol A extracts, but the downside is quiet limited, at least according to violetechos on Longecity:
“As far as NEGATIVE effects, its pretty damn benign.I take it often, and I have liver issues.I am very sensitive to depeting drugs, and the worst effect is overstimulation .Nothing like depression,body pains,sickness.”

 

On Pubmed

We find several hundred results for Schisandra Chinensis, which include a grand total of four clinical studies, which is kind of underwhelming. One of the criticisms of the adaptogens as a category is that they lack a significant quantity of human clinical studies, compared with say the Racetams or B-Vitamins.
The explanation posited for this is that since the adaptogens come from the natural world and they have been used for thousands of years, it’s more difficult to patent their pharmacological components, so there’s a whole lot less profit motive for researching them.
Keep in mind that a decent double blind, placebo controlled human study, costs about as much as a Ferrari. In between the salaries of the scientists, paying the volunteers, the lab time, the lab equipment and the publishing cost. There’s a lot of potential to cut the fat, hack away at the unessential, I’m sure, but it costs about the same as a Ferrari. Unfortunately, there’s a whole lot less motivation to spend that money when you’re dealing with a Nootropic that anyone can plant some seeds in their backyard and grow their own.

 

Cognition

There appears to be some debate as to whether it actually improves cognition or whether as an adaptogen it just attenuates negative stress hormone related effects that retard cognition.
The one double blind, placebo controlled study done that indicated a positive effect on human cognition was done using the Adapt-232 formula of which Schisandra Chinensis is just one third.

 

Adapt-232

Schisandra is one third of The Soviet Formula, Adapt-232, which was developed and refined behind the iron curtain as a performance enhancement solution by the soviet union for it’s military, athletes and space program.

 
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A Dr. Victor M. Baranov of the Ministry of Health in Moscow, wrote in regardsto the goals of herbal adaptogens in the space program, “The search for ways to maintain high mental and professional working capacity of cosmonauts at all stages of a long-term flight is the most important task of space psychology.”

Dr. Valeri Polyakov, was the scientist, cosmonaut, Russian hero and all around consummate baddass in life, who spent 437 days on the Mir space station to prove that man could survive a trip to Mars. In the tradition of scientists reaching the olive branch of peace out to former rivals in the form of shared research, he shared some of his findings at a seminar in Gothenburg, Sweden in 1996. From the abstract of his paper, The Use of a New Phytoadaptogen under Conditions of Space Flight:
“It [Adapt-232] also optimized their ability to endure the changes in (the) gas atmosphere of the spaceship.”
The interesting thing about Adapt-232 is that you can’t buy it. Google it. It’s not for sale anywhere. I’m currently researching the formula and will be selling it in a few months, join our newsletter to be notified when it becomes available.
I mention this NOT just to be self promotional but because in the 10 hours or so that I’ve spent researching Schisandra chinensis, it’s Nootropic effects are almost always mentioned in reference to Adapt-232. Adapt-232 is a bit of special formula of specific extracts in specific proportions, however you could kind of DIY your own Adapt-232 by picking up pharmaceutical grade powdered…

 

Stress

Historically, it’s praised for it’s sedative and hypnotic qualities and is used to combat insomnia. From a 2011 Jinan University study
“Fruits of Fructus Schisandrae were used as sedatives and hypnotics in traditional Chinese medicine for a long history… These results suggested that schisandra lignans extract reversed stress-induced anxiety level, changes of cortex monoamine transmitters and plasma corticosterone. The anxiolytic effects of schisandra lignans extract might be related to its anti-stress activity by modulation of hyperactive HPA axis.”

Memory

2009 Japanese study was quiet optimistic about it hacking the memory via the ACh system:
“Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits.”

Sources
 
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In supplemental form it’s quiet affordable with 30 grams, at least a 3 month supply, of powdered Schisandra 5:1 Concentrate running $19.95.
Schisandra Chinensis fruits can be brewed into wines or teas, which sounds antioxidizing and intoxicating to me!
Apparently, one of the ways they make extracts is with ethanol, Alas, Googling I was unable to find Omija Cha wine (Omija Su) anywhere online. So if you want your own Nootropic-Adaptogenic wine you will have to give some Schisandra Chinensis fruits to your friend who makes wine.

Eyesight

According to one of the most comprehensive titles on Adaptogens “Schisandra increases visual acuity and decreases eye fatigue in tasks requiring extended visual concentration.(p. 103)”

Improves Night Vision

Those who depend upon their ability to clearly discern the world between dawn and dusk should consider supplementing Schizandra…

  • Truck drivers
  • Haunted house chainsaw murderers
  • Hosts of monster searching reality TV shows
  • Nightclub bouncers
  • Snipers
  • And Skanks!
Beautifying the Skin

Schizandra has numerous youth preserving qualities, it makes the skin soft, moist and radiant. 30 days of consuming Schizandra berries has a noticeable effect on complexion.

 

Sex
 
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As an adaptogen, it unsurprisingly empowers us as sexual beings. It improves blood circulation to the genitals, which enhances sensations for both men and women.
 It’s said to create abundant sexual fluids (which just sounds fun to me!), so if your career aspirations include becoming a pornstar… Schizandra.
I hear there’s a shortage of pornstars in Japan…

 

Mechanism of Action

The active molecules in it are the Lignans

 
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and the Triterpenoids

 
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The absorption of Schisandrin lignans by the body is not great in water, so it’s a good idea to take them with fatty acids, such as fish oil.
2008 Singaporean study of 10 humans:
“In conclusion, this pilot clinical study indicates that the combined administration of sesamin with schisandra extract could improve blood fluidity after 1 week of oral intake and this effect was sustained up to 2 weeks.”

 
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Mitochondria

Part of Schisandra’s anti-oxidative mechanism is related to Hormesis; it increases Heat Shock Protein expression which fortifies the Mitochondria against future oxidative damage. From a 2012 paper:
“The enhanced cellular/mitochondrial anti-oxidant status and heat shock response afforded by SchB can preserve the structural and functional integrity of mitochondria, suggesting a potential role for SchB in ameliorating age-related diseases.”
Schisandrin B is of great interest to anti-aging researchers, from a Hong Kong University paper:
“The energy failure resulting from mitochondrial dysfunction further impedes brain function, which demands large amounts of energy… The combined actions of Sch B offer a promising prospect for preventing or possibly delaying the onset of neurodegenerative diseases, as well as enhancing brain health.”

Most of the more promising placebo controlled human studies including Schisandra, were done on the Adapt-232 formula of which Schisandra is one third of, the other ingredients are the adaptogens Eleuthero and Rhodiola Rosea.
Sesamin
One of the human studies that demonstrated positive effect on blood flow was using Sesamin extract which is also a Lignan in conjunction with Schisandra extract.

Rhaponticum and schisandra enhance reading comprehension, aptitude, and speed.(p. 94) Talk about a reading lifehack!

 

 

 
 

 


Edited by jroseland, 27 January 2017 - 08:20 PM.

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#2 PeaceAndProsperity

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Posted 27 January 2017 - 10:26 PM

Since when is spicy not fire?


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#3 jroseland

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Posted 28 January 2017 - 02:52 PM

It's not very spicy. Have you tried it?

Since when is spicy not fire?

 


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#4 PeaceAndProsperity

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Posted 28 January 2017 - 03:00 PM

It's not very spicy. Have you tried it?

You misunderstood me, I'm talking about the picture with the fire elements. Anyway, drug looks interesting.


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#5 Adaptogen

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Posted 03 February 2017 - 04:52 AM

schisandra tastes pretty vile in my opinion. and also that price is horrible. $20+ shipping should get you closer to 454 grams, not 30.

 

http://www.ebay.com/...b-/151359730691 is what I use, and at ~2.5 gram doses is one of the few adaptogenic herbs that I actually experience noticeable (but not necessarily desirable) effects from



#6 motorcitykid

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Posted 03 February 2017 - 05:22 AM

Don't overdo a good thing, it might give you man boobs.

Schisandra as a phytoestrogen

:https://www.ncbi.nlm...pubmed/15256741

 


Edited by motorcitykid, 03 February 2017 - 05:25 AM.


#7 Adaptogen

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Posted 03 February 2017 - 07:45 AM

hm, maybe so, but in vitro is not that concerning considering it's several thousand year history of use, with essentially an absence of reported side effects. resveratrol is apparently a phytoestrogen as well, but that doesn't mean it lowers testosterone or will make you grow breasts at common dosages.

either way, breast growth is a small price to pay for some of the ridiculous purported increases in work capacity the Russians found when studying schisandra, if you even partially trust the dated literature.

"Andrejev and Georgijev (1958) observed a 49.2% increase in working capacity of 19 healthy individuals who had been treated with SSP and then subjected to a classical ergographic procedure. Additionally, the maximum number of rotations of a pedal-powered machine (with a 60 kg loading) that could be accomplished prior to exhaustion by a group (n = 7) of healthy subjects increased twofold ( cf. with control) following administration of a single dose (1 g) of SSP ( Yefimova et al., 1954 ). In the same test, a 1.5 g dose of SSP has been reported to increase the working capacities of groups of students (n = 41) from 620 kg/m (mean value recorded with the placebo group) to 1736 kg/m (mean value for the treatment group) ( Kokhanova et al.,1950 )."
 

http://www.sciencedi...37887410800216X

 



#8 motorcitykid

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Posted 04 February 2017 - 04:29 AM

hm, maybe so, but in vitro is not that concerning considering it's several thousand year history of use, with essentially an absence of reported side effects. resveratrol is apparently a phytoestrogen as well, but that doesn't mean it lowers testosterone or will make you grow breasts at common dosages.

either way, breast growth is a small price to pay for some of the ridiculous purported increases in work capacity the Russians found when studying schisandra, if you even partially trust the dated literature.

"Andrejev and Georgijev (1958) observed a 49.2% increase in working capacity of 19 healthy individuals who had been treated with SSP and then subjected to a classical ergographic procedure. Additionally, the maximum number of rotations of a pedal-powered machine (with a 60 kg loading) that could be accomplished prior to exhaustion by a group (n = 7) of healthy subjects increased twofold ( cf. with control) following administration of a single dose (1 g) of SSP ( Yefimova et al., 1954 ). In the same test, a 1.5 g dose of SSP has been reported to increase the working capacities of groups of students (n = 41) from 620 kg/m (mean value recorded with the placebo group) to 1736 kg/m (mean value for the treatment group) ( Kokhanova et al.,1950 )."
 

http://www.sciencedi...37887410800216X

 

 

Yes I agree Adoptogen at recommended dose schisandra is fine. Just thought that I'd point out that anyone considering taking a heaping more on a daily basis might want to consider the potential downside.

 


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#9 warmerdam

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Posted 04 February 2017 - 12:25 PM

Thank you for doing the research. Very interesting indeed.

 

 

 

The interesting thing about Adapt-232 is that you can’t buy it. Google it. It’s not for sale anywhere. I’m currently researching the formula and will be selling it in a few months, join our newsletter to be notified when it becomes available.

 

I see Adapt–232 is available on iHerb:

http://www.iherb.com...-capsules/36209

Do you think it's a genuine product?
 

Thanks again.

 

EDIT: Just noticed that it's out of stock and discontinued. Which is strange by itself.


Edited by warmerdam, 04 February 2017 - 12:29 PM.


#10 Oakman

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Posted 05 February 2017 - 05:50 PM

Thanks for the very informative and interesting discussion of Schisandra and Adapt-232. It appears pretty easy to assemble the various components of Adapt-232 described, the question is the relative amounts in the formula. Any idea about what those might be?  I also see there is a "new" version of Adapt-232 called Swedish Herbal Institute, Adapt Life (with Adapt 232) - x60Vcaps  that adds B1, B2, B5, B6, which seems done just to call it 'new', but whatever...their description of this 'new' version suggests one to two 1400mg doses daily, but still no relative amounts given.

 

Adapt Life is a patented food supplement that reduces tiredness and fatigue. Adapt Life is developed and manufactured in Sweden, from plant raw material to finished product. Adapt Life® helps you cope with stress and strain. Adapt Life is a food supplement that gives you the chance to enhance stamina, maintain health and to concentrate. Simply a product for those who want to continue to feel good. Adapt Life contains a proven and patented complex ADAPT 232 S, with pantothenic acid, polyphenols, lignans, and triterpenoids from adaptogenic plants included. The idea of pantothenic acid originally came from a discussion between Georg Wikman, founder of the Swedish Herbal Institute, and Professor Denham Harman, American physician and perhaps the world's foremost pioneer in the research and development of free radicals impact on aging. The discussion highlighted how pantothenic acid and adaptogens can help the body's energy, strength and endurance, and also be good for memory and concentration. In cooperation with well-known scientists in biomedicine at various universities and institutions ADAPT 232 S was developed. The adaptogens included provides a vital system that gently affects every cell in your body. When you take Adapt Life you will therefore notice a quick effect, usually within a few hours. Adapt Life® is patented to age-related diseases Getting old is not a disease. However, the risk of disease increase when we become older. Blood pressure rises, the heart does not pump as well, kidney cleanses are not as effective, the memory begins to fail - you become tired and cannot cope as much as before. This may begin to be noticed already in middle age.

Can you slow down or delay the development of aging? Yes, Swedish Herbal Institute adopted the challenge for over 20 years ago. The Institute's research demonstrates significant and promising results. Both in terms of increasing physical and mental performance, which is to contribute to reducing the occurrence of age-related diseases. While the multinational pharmaceutical industry in their place were among the synthetic substances, the Institute's research team turned towards a group of biologically active substances of natural origin known in pharmacognosy, namely adaptogens. Adaptogens has since then become the official name for these substances which both the EU's European Medical Agency and the US Food and Drug Administration (FDA) has approved

Important synergies By combining different herbal adaptogens Swedish Herbal Institute have succeeded in producing more and better activities than for individually adaptogens. The function and effect of Adapt Life® is a direct result of the exact composition. But the best way to be convinced about Adapt Life's ability to enliven, energize and restore the balance, is simply to try when you feel tired, and whether your fatigue is due to physical exercise, hard work and late entertainment. The synergetic effect has been shown to enhance the cellular defense system, increase mental and physical performance even in well-trained space crews and elite athletes and indeed extended the life of various animals, including mice and rats, says the research institute’s leader Georg Wikman.

 

To construct Adapt-232 DIY:

 

Schisandra Powder on Amazon  ... very inexpensive e.g., 500g @ $18.96 

Compared to the expensive version 30g 5:1 concentrate, not sure the difference other than the 5:1 concentrate? 

 

Rhodiola Rosea (3% Rosavin) on Amazon  ... a bit more e.g., 100g @ $24.96

or perhaps this is what was used in their formula Swedish Herbal Institute, Original Arctic Root Rhodiola Rosea, SHR-5, 40 Capsules

 

Last, the quality Ginseng mentioned by the OP, on Amazon @ $33.99

 

 

Also found this: Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells discussing gene activation of Adapt-232.

 

plus if you do a search in the forum here there are many references to Adapt-232 over the years, with varied opinions. Nevertheless, might be worth ordering up an ebay box of the Adapt Life to chek it out. As with so many things offered, "It's a miracle!", if only!



#11 Ark

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Posted 05 February 2017 - 06:26 PM

I'd like to find a verified ultra pure super extract of schisandra, does anyone have a suggestion?

Thanks!

Edited by Ark, 05 February 2017 - 06:27 PM.


#12 jroseland

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Posted 07 February 2017 - 06:46 PM

Lost Empire Herbs is the best source I think you'll find outside of Buddhist monastery on the side of a mountain. They are the one herbal vendor I know of that does...

Certificate of Analysis
Complete Mineral and Heavy Metals Report
Microbiology Report

I'd like to find a verified ultra pure super extract of schisandra, does anyone have a suggestion?

Thanks!

 


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#13 Oakman

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Posted 22 February 2017 - 06:10 PM

I've purchased the three ingredients (mentioned in my previous post) and today started taking something like Adapt-232 (and/or Adapt Life) formula, that is...

 

910 mg  - Bulk Supplements - Schisandra (fruit)

900 mg  - Auragin - Korean Ginseng root, 6 yr old (8% ginsenosides)

400 mg  - Bulk Supplements - Rhodiola Rosea (3% Rosavin)

----------

2210 mg

 

As I don't know the exact proportions in the original commercial products, I'll combine the recommended serving size for each product. Over the next 30 days (what I have supply for currently), I'll report if I feel can actually notice any of the advertised benefits (or anything else), i.e., "The synergetic effect has been shown to enhance the cellular defense system, increase mental and physical performance even in well-trained space crews and elite athletes and indeed extended the life of various animals, including mice and rats..."

 


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#14 nooguyz

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Posted 03 March 2018 - 12:20 PM

I remember eating berries of this, and I remember being told that I should not eating too many because it will raise my heart rate too much.

 

I also remember that when I was younger it either didn't do anything or made me slightly more energetic or in better mood, although I was also drinking plenty of coffee and such...

 

When I was a bit older, I had 95% ethanol extract, and I was taking a teaspoon a day (not sure what's the ratio), and it didn't do anything.

 

I also took it at highschool for awhile in hopes to improve my energy levels when being severely sleep deprived, but it either didn't do anything or made me even more sleepy.

 

So I don't have much to go on here, and while I am really excited by this herb (and it tastes great, at least fresh berry), I would like to read more experience reports before I splash the little money that I have on it. For now, I'll stick to supplements that have a lot of reports.

 

To me it just seems like something that reduces heavy stress and at least improves physical performance. I am in a practical need of MAOIs and increased production of neurotransmitters, so this would probably not cover it or would just have a slight effect on some days. Or maybe it would make me sleepy when I want to stay awake and try to do something productive, like I think it did a couple of times in the past.

 

Looking forward to more people actually trying it either without other stacks or with a clear perception of its effects in the areas I mentioned that are important to me. Not expecting it though, as it seems very underreasearched and unknown... :/



#15 Galaxyshock

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Posted 07 March 2018 - 05:17 PM

Schizandra makes my skin tone much better, a mild glow even, and has pleasant smooth adaptogenic effect. For some reason it tends to make people give you more looks too (in a positive way).


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#16 nooguyz

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Posted 08 March 2018 - 04:36 AM

Schizandra makes my skin tone much better, a mild glow even, and has pleasant smooth adaptogenic effect. For some reason it tends to make people give you more looks too (in a positive way).

I have also noticed that if used properly and more than 1-2 berries (what I was told when I was growing up), you get plenty of health improvements on your outlook. It's hard to identify exactly what, but it was noticeable somehow.



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#17 jroseland

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Posted 25 November 2021 - 07:51 AM

I've discovered that consuming Adaptogens like Schisandra Chinensis as a tea is a whole lot more of a Nootropic experience. This earthy, fruity, yet hearty-tasting tea energizes me within about 15 minutes of drinking it. The Adaptogen tea buzz seems to last a couple of hours and has a positive effect on mood.
On Pubmed over 1000 scientific papers published about it can be found. Here I'll summarize the recent science and studies...
 
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Watch: "The Tastiest Nootropic!" Why Schisandra is the Adaptogenic Herb for Vain & Antifragile Biohackers







Also tagged with one or more of these keywords: schisandra, adaptogen, herbal medicine, chinese medicine, sex, hepatoprotective, skin, mitochondria

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