So far, the most useful antidepressant for cognition, that I've found is Selegiline, after a years of depression, it was the only one who gave me a lot of energy/motivation and cognition, the dose I've found most effective so far is 40 mg sublingual, A couple of months ago, I've used to take 450 mg Bupropion, but as many people suggest, it causes you to forget what you did yesterday, yeah it give a lot of energy/motivation/happyness and cognition, but it takes too much, watch the movie "Click" it's like someone pushed the rewind button and you just skip your life away, my mom takes 300 mg of it and as she says she doesn't have the same effect as I did, but she still smokes a lot though the day, maybe this helps it. I've tried 3 tabs of Phenypiracetam (Which I also take every day now, it adds a boost of energy to my giant stack) to combat memory issues, it didn't work, I've 7.2 gramms of Piracetam and it also didn't work. Galantamine and Donepezil , they were so far the only useful meds to combat this issues, I've also read lostfalco's suggestion, that PDE4/PDE5 helps a lot with cognitive issues and helps you body to sustain longer and also give you additional years to live, so I've imagined that what if there non-selective cheap PDE inhibitor and I've found that Pyritinolum also give me a LOT of energy and motivation, helps me with my mood and cognition, so I've added it to my stack, it's cheap and so useful drug, so I would suggest it to take it. I also take 100 ,; PhenylPiracetam 10 mg Noopept (sublingually works better, but I'm too lazy ot take it this way 3 times a day) 300 mg of Alpha-GPC (CDP-Choline didn't help with headache and short-term memory impairment caused by Bupropion, I also take Intranasal Insulin 120 mg 3 times a day, it also helps a lot with cognition and maintain your brain health, just as other nootropics I've listed so far, to be sure, that nothing is gonna get badly with my liver and kidneys, I take 125 mg of Emoxypine, 400 mg Sam-E, 2400 mg NAC, they also helps me a lot with mood/energy/motivation and are gonna make my life both longer and gonna make it's quality higer. Lamotrigine helps me to balance the effect of my stack, so it wouldn't cause any harm to me. I also take 120 mg Strattera, because I don't feel like I get the full effect on my cognition cause of Selegiline, I suggest to also use it, it also lowers a blood pressure (just as Emoxypine) it doesn't give any side-effects in combination with MAOI (btw I also wait for Parnate to be delivered to me, so I'm gonna switch from Selegiline to Parnate very soon, I've read it's most effective antidepressant and motivation/mood booster (but I also take Deschlorketamine for depression IT'S REALLY WORKS BEAUTIFULLY, I'm able to purchase it illegaly by using darknet, so, I won't stop taking it, because the effect it gives me is really true magic. Because I have SEVERE benzo withdrawal I also take Gabapentin 300 mg 3 time a day (I think, it's not so useful, because of Emoxypine, so maybe, I'm gonna stop to take) Also I suggest to try Azaphen MB, it's very new russian TCA that works almost the same, like imipramine in terms of giving you energy/motivation/mood, but doesn't cause ANY dementing anticholenrgic side-effect, I would suggest to try it, before switching to MAOI. Even that Cymbalta is more 'balanced" in terms of SERT/NET ratio, it's very unbalance when we talk about region specific side-effect after subcrhonic and chronis use, so basically it makes you apathetic, because of it's sedating effect, you can read about it here https://www.ncbi.nlm...pubmed/18751896, so it's very weird and dangerous antidepressant, never think about taking it, Venlfaxine is very balanced and that's why helpful antidepressant in compare to Cymbalta, even that it has crazy SERT/NET ratio, but AFAIK it's only theory and when you actually try it, you would find out, that it's much better than Cymbalta/Levomilnacipran/Milncapran in terms of energy/mood/motivation, but why anyone would take, if you can buy cheap TCA/MAOI, that would be much-much better than any SNRI/SSRI. Other SSRIs and SNRIs are useless shit, that really won't help anyone with depression, except for people who have a bit lower than perfect mood, lol. Goldpharm isn't scam, so anyone can simply make an order there and get EVERY antidepressant you want. Just as in Australia, psychiatrists in Russia, also think that Atypical Antipschytics are cure for everything (that would they told to EVERY people who asked psychiatrist for help) they just simply want you to be passive vegatable who agrees with everything they say, so you would just simply get rid of you can take care of next patient, it's so cruel V___V, but I think that Abilify actually can work good for energy/motivatin/mood, after I'm gonna run out of Amisulpiride (that block presynaptic D2 receptors in dosage of 50 mg and doesn't have any effect on block other D2 recepetors. Idebenon and Meldonium somewhat helps with physical energy, but after I'm gonna run out of them, I'm gonna stop buying, I can't feel their effect, except that I' able to do sports a little longer (Naltrexone thanks to relaxing effect cause by partial opiod agonism help betters with it. T3/T4 augmentation helps MUCH BETTER with mood/energy/cognition, and just everybody else on this forum, I think that I have SCT, so those drugs I take helps with this, so I don't suggest anything that doesn't help with it, so please, people, listen to what I say, thanks to careless russian pharmacist, I'm able to buy EVERY kind of med I want, so thats why I have so massive drug experience. I've tried NSI-189, it helped me with depression, but.. the last order on intellimeds lost in delivery thanks to very "qualified" russian postal workers and they didn't make any money return, so I look forward, when I'm gonna have extra money, I'm gonna buy more NSI-189 in other shop, because it's really miracle drug, just as Deschlorketamine. Dihexa is actually bullshit for depression. yeah-yeah it somewhat helps with creativity, but what SEVERE (A HELL LOT SEVERE than NSI-189) attention problems., doesn't really worth it, and when it wears of, you gonna feel like shit and al lmy other meds didn't help with my mood/energy/motivation/cognition, that was downregulated by it, I still keep a bottle of dihexa dissolver in 99.8% DMSO solution.
I have very bad scores on HAM-D test, (but somewhy, every psychiatrist I've met didn't gave me this test, oficially I have GAD, Panic Disorder, ADHD-C and MDD diagnosys, but just as everyone here, I don't think they can really describe every cognitive/mood/motivation trouble I have. I have almost perfectly diet, that I try to maintain every day (not every day, thanks to my problems, lol). Don't ever think to try Setraline, I've used 200 mg of it for a couple of weeks, after I've stoipped to take Effexor XR, after I've spen a lot of time on searching info on web, I've found out, that thanks to it sigma antagonism, it's actually makes you apathetics and it has NO EFFECT on DA firing rate, actually it lowers it (at least in my case) yeah, DA agonist that I've tried so far (Bromocritine, Pramipexole, Cabergolone and Ropinirole) are VERY helpful, but I'm somewhy scared of taking 'em together (because I actually have Pituitary gland caused by antidepressant fluoxetine I've used to take, I don't actually know what kind of hormone it's secretes, so to be sure that I'm gonna be a-ok, I use bromocriptine 3 times a day, Ropinirole is the best in class DA agonist, but I don't know if it helps with my tumor, so I stay away from it. I also take SERM called radarin, even that I'm a gurl (lol, yeah-yeah I'm TS MtF, whatever) it doesn't have any masculinization effect, but on the other hand it gives me a lot of energy thanks to cAMP boost, you can read an articles on pubmed about it. I also take 49 mg of memantine, it also helps with all the troubles I've list here and to be sure, that I'm not gonna lose any potency of my meds, I'm not gonna stop taking it, even that I take deschlorketamine (I don't think, that I'm gonna use it forever lol). My GAD didn't go away thanks to all the meds I take, so I've started to take Buspar (it's really helped my with both of my social anxiey amd GAD ANNNDD... it also helped me with hand tremor, so I no longer troubles with makeup apply that I had for many years now. I also used to take 400 amantadine, as the doc Hallowell suggests in his book, it's really work better, than Strattera and Memantine, but I think it's bad for my liver, so I've stopped taking it. Aannndd.. that's it. It's all of my experience so far... I'm open to questions, about my current condition (and it's almost perfect, but I have some troubles with OCD, after I've stoped taking Amantadine that I have since I was a child). I'm so afraid of cognitive issues caused by sex, so I sway away from it (even that I have bf that also have the same symptoms as we do, he also has anorgasmia thanks for the Escitalopram that he used to take with Seroquel (Hello "very qualified pdocs!" so I just try not to think about sex. And the last thing.. BPC-157 injections also helped me with my physical and mental health, so I if I'm gonna have any more money, I'm gonna buy more of it, it also helps with my liver and kidneys that are affected by that monster stack I take. Vitamins like Opti-Men (that I'm gonna change to better, like Empower Plus, that I hope I'll be able to get by using shipito, because I don't have anyone in US, who could help me with the delivery.
I hope, that my experience would help you with all the suffering we have ( But, I actually think, if we didn't have such issues, we won't have knowledge of medicine, that helped us to improve in_diffrent_terms (and maybe better than normies have) that somewhat helps me not to commit suicide (I've tried to do so multiple times, thanks to all the hate I'm gone through my difficult life in Russia, because of my nerdyness and gender issues, that normies can't understand and just make me hate myself. Please, ask any question about my experience and I also open to your suggestion to try other meds.
Edited by Lia-chan, 23 February 2017 - 01:49 PM.
