20 replies to this topic

[KieranA001]

Hey,

 

I cannot seem to find anything on the internet about what causes the brain fog / cognitive dysfunction relating to depression / anxiety nor what I can try to help remove this burden from my life. Does anyone know what helps with this. 

 

Regards,

Kieran

[Mind_Paralysis]

Well, first of all, do you suspect any other issues other than "just" depression?

I.e, something else which could account for cognitive dysfunction? The first thing to consider is if you have any commorbidities, since that could hold cognition back as well.

 

With that said, these are the antidepressants which have been implicated towards having better results on cognitive function in depression, than other antidepressants:

 

Venlafaxine

Duloxetine

(the two above are SNRI's, which have been proven as more effective against anxiety, than several other classes of drugs)

 

Bupropion (probably not good for you, since you have anxiety as well)

Reboxetine (efficacy on depression itself is sh*t though)

 

Tianeptine

Vortioxetine

 

 

As to what causes the cognitive issues... well, I don't quite know - the more plausible theory I can assess is that since neuroplasticity (i.e, the ability of the brain to reform and resculpt itself, to adapt to the situation at hand, but also to heal damage) have been found to be impaired in patients with depression, hence why neuroplasticity and neurotrophy is believed to be promising new areas and drugs for research, this also results in not just impaired emotional control, but also in impaired cognitive function.

 

As for cognitive deficits in anxiety - I haven't a clue... Neuroplasticity seems to be involved as well, but the case is NOT as clear as it is with depression - especially in light of the fact that anxiety seems to be, at least in part, connected more to excessive activity in the glutamatergic and serotonergic networks of the brain.

(i.e, hence why it takes longer for serotonergic AD's to work on anxiety than depression, why higher dosages are needed - it eventually causes down-regulation of serotonergic receptors, leading to lessened serotonergic activity. The glutamatergic activity also explains why NMDA-antagonists like Memantine can often be highly effective in the treatment of anxiety)

 

 

References:

------------------

A Review of Modern Antidepressants Effects on Neurocognitive Function - 2009

https://www.research...nitive_Function

 

Pharmacological and non-pharmacological interventions to improve cognitive dysfunction and functional ability in clinical depression – A systematic review

http://www.sciencedi...165178114003849

 

The Cognitive Effects of Antidepressants in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

https://www.ncbi.nlm...les/PMC4772818/

 

Treatment of cognitive dysfunction in major depressive disorder—a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine

http://www.sciencedi...014299914005822

(in the above study, they find that there is some evidence that in RATS, Vortioxetine is better for cognitive impairment than SSRI's or SNRI's - but this is in rats - it's not as clear-cut for humans)

[AOLministrator]

There are different causes for depression:

 

1. you are depressive, because you turned out as crazy

      Examples: mania, psychosis, and whatever neurotic disorders that put your life into chaos and misery

2. you are depressive as a result of being dumb and/or lazy

      Examples: poor cardiovascular fitness, psychological drug dependence (too much cannabis, Phenibut and alcohol), eating Burgerking all day, veganism, idiotic ideologies and useless empathy

3. you are always depressive, because you are a freak of nature

      Examples: your ancestors were loners who thrived on sadness and worry in some desolated rural area, or too much incest and alcoholism degraded your genes

4. you are depressive / busted / fucked forever, because some shit has or still is damaging your system

      Examples: environmental toxins (e.g. heavy metals), fungus inside the brain or ass, using harmful drugs like cocaine, Ritalin, antidepressants, Heroin, antipsychotics, alcohol for too long, autoimmune tendencies that have yet to destroy your organs entirely (Hashimoto's, Addison's, Multiple Sclerosis, whatever), doctors who stole your organs and told you it will be all fine

5. you are depressive as a result of food intolerances, nutrient absorption deficiencies that increase with old age, or crappy metabolism

      Examples: MTHFR, lack of B12, fructose, lactose yadda yadda intolerance

6. you aren't depressive, you are merely going through a difficult phase in your life (teenagers and young people, losing loved ones, shitty job, shitty family life, shitty social life, no GF / still a virgin)

 

So as you can see, some of those causes can degrade your cognitive fitness. Some are irreparable. But not everyone is fucked for life, some just don't have brain damage, some aren't even ill anymore, but just have issues like everyone else. So much shit that hides under the cover of depression.

 

Tips on being crazy, lazy and dumb are obvious - the rest you have to research yourself. Of course you could just be crazy, for the same underlying reason that makes you depressive. Best example is bipolar without a real mania (as in turning into a megalomaniac and only sleeping an hour a day for a week, once every few month). I can give you a whole program, but it depends. Some got stolen organs, you need different supplements. Just too many causes. I will make a website about it soon.

Edited by AOLministrator, 28 February 2017 - 12:48 AM.

[Lia-chan]

May I suggest something? I think, that Lamictal 200 mg + Ketamine 100 mg + Methamphetamine ? (Maybe 1 gr., for example) and some Valium -- work the best for anyone, I think,. that everyone here, should try this combo, AFAIK this works for anyone. Soon I'm gonna try this combo and I hope, it's gonna help EVERYONE on this forum. Cheers, guys. I wish you, some luck, because, you'll need it.

[Mind_Paralysis]

May I suggest something? I think, that Lamictal 200 mg + Ketamine 100 mg + Methamphetamine ? (Maybe 1 gr., for example) and some Valium -- work the best for anyone, I think,. that everyone here, should try this combo, AFAIK this works for anyone. Soon I'm gonna try this combo and I hope, it's gonna help EVERYONE on this forum. Cheers, guys. I wish you, some luck, because, you'll need it.

 

What...?

 

Lia-Chan, are you being sarcastic and making a joke, or something? : \

 

Two of those drugs are dangerous and illegal, you know - I seriously hope you're not going to be combining such potent drugs in such a potent cocktail - you could end up hurting yourself very, very seriously.

[sthira]

May I suggest something? I think, that Lamictal 200 mg + Ketamine 100 mg + Methamphetamine ? (Maybe 1 gr., for example) and some Valium -- work the best for anyone, I think,. that everyone here, should try this combo, AFAIK this works for anyone. Soon I'm gonna try this combo and I hope, it's gonna help EVERYONE on this forum. Cheers, guys. I wish you, some luck, because, you'll need it.

Please don't. I understand your frustration and desperation; but this combo will send you down deeper. Instead, take a walk in the woods, surround yourself with trees and sky and birds and blowing wind. Sit on a rock ledge, look up at the indifferent sky, and offer up your middle finger to the cursed god or evil genetic inheritance or screwy childhood trauma that inflicted you with disease.

And scream: scream loudly scream like a diving hawk: because aint no fucking medical cure yet for suicidal depression.

But wait: we read every day that more effective crazy meds are coming. Exclaimaion point high up! Within five years! Haha, yeah, and within five years we'll have more mouse depression data, we'll have more suppressed negative outcome data from pharmaceutical companies capitalizing off human suffering, we'll have more freedom of information requests to prove that everything on the pharmaceutical pipeline currently prescribed for depression ain't nothing but goddamned placebo.

Hike into the trees: go outside. Scream, hawk, scream like hell.

[Lia-chan]

 

May I suggest something? I think, that Lamictal 200 mg + Ketamine 100 mg + Methamphetamine ? (Maybe 1 gr., for example) and some Valium -- work the best for anyone, I think,. that everyone here, should try this combo, AFAIK this works for anyone. Soon I'm gonna try this combo and I hope, it's gonna help EVERYONE on this forum. Cheers, guys. I wish you, some luck, because, you'll need it.

Please don't. I understand your frustration and desperation; but this combo will send you down deeper. Instead, take a walk in the woods, surround yourself with trees and sky and birds and blowing wind. Sit on a rock ledge, look up at the indifferent sky, and offer up your middle finger to the cursed god or evil genetic inheritance or screwy childhood trauma that inflicted you with disease.

And scream: scream loudly scream like a diving hawk: because aint no fucking medical cure yet for suicidal depression.

But wait: we read every day that more effective crazy meds are coming. Exclaimaion point high up! Within five years! Haha, yeah, and within five years we'll have more mouse depression data, we'll have more suppressed negative outcome data from pharmaceutical companies capitalizing off human suffering, we'll have more freedom of information requests to prove that everything on the pharmaceutical pipeline currently prescribed for depression ain't nothing but goddamned placebo.

Hike into the trees: go outside. Scream, hawk, scream like hell.

 

Thanks for a great suggestion... I have now sort of understanding, what really happening to me. Maybe it's gonna sound ridiclous, but it's all about enviroment, I hope in the near future, someone or some company would be able to take of that, but everything we have now -- is to wait. That's it, I don't want to become an alcoholic these years, I hope that I have enough powers to be able to survive these years, so thanks you for a great tip, I'm gonna be sure, that it's gonna help.

[sthira]

Please don't become an alcoholic, the world has more than plenty of alcoholics attempting to self-medicate their pain and depression. Alcohol, for us depressed people, is not a solution. It's just not. I don't touch alcohol because it's really a false friend: while it temporarily makes me feel better, those good feelings are dwarfed by side effects.

And for what it's worth, no, it doesn't sound ridiculous at all that your environment is contributing to the depression. I try to isolate those environmental factors that make me feel worse, and rid them. This isn't always possible, but hey, we do what we can.

I'm happy you're reconsidering the toxic mix you outlined above and threatened us with: this decision alone, that you're not choosing that path, has made my day a better day. And so thank you!

[Lia-chan]

Thanks, after your suggestions and the help of my dad, I've finally understood, that it's not an answer. The only mix, I hope's gonna work for me is the Parnate + Nortryptiline + Lamictal + P21 and I hope, that both of my mania/hypomania after I'm gonna start this combination would never come back. Now, I take only 300mg of Lamictal + some nootropics that are left in my box with a meds.

[KieranA001]

Well, first of all, do you suspect any other issues other than "just" depression?

I.e, something else which could account for cognitive dysfunction? The first thing to consider is if you have any commorbidities, since that could hold cognition back as well.

 

With that said, these are the antidepressants which have been implicated towards having better results on cognitive function in depression, than other antidepressants:

 

Venlafaxine

Duloxetine

(the two above are SNRI's, which have been proven as more effective against anxiety, than several other classes of drugs)

 

Bupropion (probably not good for you, since you have anxiety as well)

Reboxetine (efficacy on depression itself is sh*t though)

 

Tianeptine

Vortioxetine

 

 

As to what causes the cognitive issues... well, I don't quite know - the more plausible theory I can assess is that since neuroplasticity (i.e, the ability of the brain to reform and resculpt itself, to adapt to the situation at hand, but also to heal damage) have been found to be impaired in patients with depression, hence why neuroplasticity and neurotrophy is believed to be promising new areas and drugs for research, this also results in not just impaired emotional control, but also in impaired cognitive function.

 

As for cognitive deficits in anxiety - I haven't a clue... Neuroplasticity seems to be involved as well, but the case is NOT as clear as it is with depression - especially in light of the fact that anxiety seems to be, at least in part, connected more to excessive activity in the glutamatergic and serotonergic networks of the brain.

(i.e, hence why it takes longer for serotonergic AD's to work on anxiety than depression, why higher dosages are needed - it eventually causes down-regulation of serotonergic receptors, leading to lessened serotonergic activity. The glutamatergic activity also explains why NMDA-antagonists like Memantine can often be highly effective in the treatment of anxiety)

 

 

References:

------------------

A Review of Modern Antidepressants Effects on Neurocognitive Function - 2009

https://www.research...nitive_Function

 

Pharmacological and non-pharmacological interventions to improve cognitive dysfunction and functional ability in clinical depression – A systematic review

http://www.sciencedi...165178114003849

 

The Cognitive Effects of Antidepressants in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

https://www.ncbi.nlm...les/PMC4772818/

 

Treatment of cognitive dysfunction in major depressive disorder—a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine

http://www.sciencedi...014299914005822

(in the above study, they find that there is some evidence that in RATS, Vortioxetine is better for cognitive impairment than SSRI's or SNRI's - but this is in rats - it's not as clear-cut for humans)

 

 

Hey thank you for that information it has been very useful. The main symptom I am trying to fix or cope with is the brain fog. I might try and find a way to cholinergic anti-inflammatory pathway activation but I cannot find anyway of doing it. I might give this product a go: 

 

https://www.powermys...mniscienti.html

 

Can you recommend anything else? 

 

Thank you so much. 

[Mind_Paralysis]

I would recommend the drugs listed above - there's quite a few for you to try, as you can see. (I recommend trying Duloxetine first, since you have anxiety as well - and duloxetine is statistically the most effective against anxiety)

 

In addition however, I would recommend you try a simple choline-supplement - Alpha-GPC or CDP-Choline are good substances. That, and a good amount of Omega-3 EPA (omega-3 has different forms, dha, ala and EPA - EPA is the one which has anti-inflammatory action in the CNS).

 

HOWEVER... a word of caution... High choline has been known to ALSO cause brain-fog, and anxiety as well. We've got several threads about people who seem to be hyper-methylators when it comes to choline, which leads to problems with an intense excess of choline and subsequently acetacholine.

 

Difficulties with emotional control could also be connected to enhanced acetacholinergic activity in Borderline Personality Disorder.

 

 

So, I would recommend you go easy with choline-supplementation, if you try it - it's not sugar-pills, and not everyone should start with a high dose. Seeing as you have lots of anxiety, I would start low when it comes to supplementation.

 

Try Duloxetine and Omega-3 first - and then go from there, if you don't notice any effects after about a month or so.

 

Edited by Stinkorninjor, 04 March 2017 - 07:51 PM.

[Lia-chan]

Duloxetine thanks to anticholinergic properties... gives me severe... ahhh.. blurred vision, but it goes away...

And... I'm already taking 200 mg of Lamictal... and just as everyone with BPD... i

t helps me think...

There is something with glutamate, I think,.. just as you... I

have severe RLS, that makes me look like an idiot, and my bf doesn't like it... thaaat's it for know... I've tried just as you Gabapenting and russian drug also helps me kinda with both RLS and sorta.. with ADHD, people in russia thinks that because ADHD is neurological disease, they treat it this way, all addionally adding piracetam, phynelpiracetam/piracetam and choline source. I've tried additng to my 4800 mg of piracetam like a... 1200 Alpha-GPC and seems, like I'm not the responed. I also have an idea to give a try to Abilify, it has a LOT of disease listed and thanks to PUBMED I know that it helps with BPD. 

Let's see, I'll have to wait 12 more days and see if it's gonna happen.. and I've found that deep breathing helps me think a hell a lot better.

[KieranA001]

I would recommend the drugs listed above - there's quite a few for you to try, as you can see. (I recommend trying Duloxetine first, since you have anxiety as well - and duloxetine is statistically the most effective against anxiety)

 

In addition however, I would recommend you try a simple choline-supplement - Alpha-GPC or CDP-Choline are good substances. That, and a good amount of Omega-3 EPA (omega-3 has different forms, dha, ala and EPA - EPA is the one which has anti-inflammatory action in the CNS).

 

HOWEVER... a word of caution... High choline has been known to ALSO cause brain-fog, and anxiety as well. We've got several threads about people who seem to be hyper-methylators when it comes to choline, which leads to problems with an intense excess of choline and subsequently acetacholine.

 

Difficulties with emotional control could also be connected to enhanced acetacholinergic activity in Borderline Personality Disorder.

 

 

So, I would recommend you go easy with choline-supplementation, if you try it - it's not sugar-pills, and not everyone should start with a high dose. Seeing as you have lots of anxiety, I would start low when it comes to supplementation.

 

Try Duloxetine and Omega-3 first - and then go from there, if you don't notice any effects after about a month or so.

 

Hey,

 

For some reason choline doesn't agree with me. I tried Alpha-GPC a while ago and remember it having no effect on me, it just gave me really bad headaches. I do take a omega 3 fish oil supplement, haven't had it for a while though. It used to brighten my mood up a bit, but didn't used to clear the fog. I might go back on it though but just try taking it for longer.

 

Centrophenoxine used to be really good for helping with my mood, but for some reason after a couple uses I built up tolerance, dopamine agonists make me foggy and spaced out a lot (mucuna) and other supplements like DLPA seem to make me worse (puts me in a downer mood for at least three days if not more), I feel like the worse my anxiety gets the worse it makes my depression even though the doctors seem to think the depression is causing the anxiety it's a hard one to find out what's causing what...

 

Remember my brain fog going away once before, all I did was sit down the beach after taking Kratom in the morning, I sat down there in the morning until the late afternoon / swam in sea for a bit then went home feeling very anxious and my vision was a bit (delayed), as such with a black shadow affect when moving my eyes in the corners, next thing I remember is having some chips and a glass of milk then went to bed feeling anxious / energetic and woke up without brain fog.

 

Three days after, the fog came back gradually and was back to foggy brain again. Cannot seem to replicate that solution again. Tried everything since, D3 supplements, sun exposure, drinking milk for the calcium, taking Kratom but nothing fixes it.  

[KieranA001]

So far the best stack which seems to help me the most is: 

 

• Vitamin C with Quercerin 
• Curcumin Extract 
• L-Tyrosine

 

[Mind_Paralysis]

 

So far the best stack which seems to help me the most is: 

 

• Vitamin C with Quercerin 
• Curcumin Extract 
• L-Tyrosine

 

 

HMM!

 

Vitamin C and Curcumin both have powerful anti-inflammatory effects - could there be a connection to your brainfog there? Check out my thread regarding various novel anti-inflammatories, which actually cause bigger effects in the brain, than the older, standard anti-inflammatories - in theory, some of them could be synergistic with antidepressants when it comes to treating depression - and brain-fog is a part of depression.

 

Link:

http://www.longecity...inflammatories/

 

 

L-Tyrosine... hmm... and you react badly to Cholinergic supplementation... Choline and dopamine are both connected, in the way that if your dopaminergic activity rises, your acetacholinergic activity lowers - and vice versa.

 

Could you be afflicted with Atypical Depression?? It seems to be a state connected not just to the inflammatory and neuro-atrophic effects seen in regular depression, but also with dopaminergic problems.

 

Read more here:

 

https://en.wikipedia...ical_depression

 

 

If you have that, and since you have anxiety as well, then I think low-dose BROMANTANE could actually be useful! : D Bromantane causes upregulation of the process which SYNTHESIZES dopamine - that's the source of its stimulant properties - which is wholly different from traditional stimulants. Unlike traditional stimulants, Bromantane is also highly anxiolytic! It's actually pretty good with anxiety.

 

Read more here:

 

https://en.wikipedia...wiki/Bromantane
 

 

I can understand not wanting to order Bromantane online though, seeing as it's not available outside of the Russian Federation, so I would suggest trying out BUPROPION (wellbutrin, voxra), as an adjunct to an SSRI, and see what the results would be.

 

So, maybe a stack like this, then?

 

• Vitamin C with Quercerin 
• Curcumin Extract 
• L-Tyrosine
• Escitalopram 10 mg (there are some indications that Esci could be better than other ssri's)
• Bupropion 150 mg

• Montelukast 20 mg (asthma-medication, decreases neural inflammation)

 

One of the reasons why Bupropion has a limited clinical use, is the fact that it has POWERFUL ANTICHOLINERGIC properties - it antagonizes nicotinic Acetacholine-receptors, which is why it's also used a treatment for ceasing smoking. You however, does seem to have somewhat higher cholinergic activity than others, so you should NOT be bothered by these effects - in fact, perhaps the anticholinergic effects could be USEFUL in you?? : D

 

With that said, the only other antidepressants which have any significant anticholinergic properties, the TCA's, have been found to be ineffective in the treatment of Atypical Depression... so something to keep in mind.

[KieranA001]

 

 

So far the best stack which seems to help me the most is: 

 

• Vitamin C with Quercerin 
• Curcumin Extract 
• L-Tyrosine

 

 

HMM!

 

Vitamin C and Curcumin both have powerful anti-inflammatory effects - could there be a connection to your brainfog there? Check out my thread regarding various novel anti-inflammatories, which actually cause bigger effects in the brain, than the older, standard anti-inflammatories - in theory, some of them could be synergistic with antidepressants when it comes to treating depression - and brain-fog is a part of depression.

 

Link:

http://www.longecity...inflammatories/

 

 

L-Tyrosine... hmm... and you react badly to Cholinergic supplementation... Choline and dopamine are both connected, in the way that if your dopaminergic activity rises, your acetacholinergic activity lowers - and vice versa.

 

Could you be afflicted with Atypical Depression?? It seems to be a state connected not just to the inflammatory and neuro-atrophic effects seen in regular depression, but also with dopaminergic problems.

 

Read more here:

 

https://en.wikipedia...ical_depression

 

 

If you have that, and since you have anxiety as well, then I think low-dose BROMANTANE could actually be useful! : D Bromantane causes upregulation of the process which SYNTHESIZES dopamine - that's the source of its stimulant properties - which is wholly different from traditional stimulants. Unlike traditional stimulants, Bromantane is also highly anxiolytic! It's actually pretty good with anxiety.

 

Read more here:

 

https://en.wikipedia...wiki/Bromantane
 

 

I can understand not wanting to order Bromantane online though, seeing as it's not available outside of the Russian Federation, so I would suggest trying out BUPROPION (wellbutrin, voxra), as an adjunct to an SSRI, and see what the results would be.

 

So, maybe a stack like this, then?

 

• Vitamin C with Quercerin 
• Curcumin Extract 
• L-Tyrosine
• Escitalopram 10 mg (there are some indications that Esci could be better than other ssri's)
• Bupropion 150 mg

• Montelukast 20 mg (asthma-medication, decreases neural inflammation)

 

One of the reasons why Bupropion has a limited clinical use, is the fact that it has POWERFUL ANTICHOLINERGIC properties - it antagonizes nicotinic Acetacholine-receptors, which is why it's also used a treatment for ceasing smoking. You however, does seem to have somewhat higher cholinergic activity than others, so you should NOT be bothered by these effects - in fact, perhaps the anticholinergic effects could be USEFUL in you?? : D

 

With that said, the only other antidepressants which have any significant anticholinergic properties, the TCA's, have been found to be ineffective in the treatment of Atypical Depression... so something to keep in mind.

 

 

I will definitely take that stack into consideration. I was thinking of trying Bromantane again, as last time I tried it I had very bad mood swings / depression and kept taking it out on everyone and felt quite anxious with a headache to the point where I'd say the headache was worse than the choline.

 

Nicotine seems to help me as well in regards to the brain fog so the bupropion might help me quit as I know it's not good for me (only been smoking a couple months) I'm not sure what type of depression I have as I wasn't told by my doctors, just that I feel my anxiety is caused by my brain fog / spaced out body feeling / it's kinda like a depersonalization / derealization  

[KieranA001]

If you know anything about 23 and me also, then these are my results from Genetic Genie: 

 

Methylation Results:

VDR Taq: Alleles AA Results ++ BHMT-08 Alleles TT Results ++

Detox Profile:

SOD2 A16V Alleles GG Results ++

[Elroy]

Hi Kieran,

Things that help me with brain fog:

- Noopept
- after food, .15cc scoop of Uridine Monophosphate, .15cc scoop of Choline Bitartrate, high DHA fish oil (too much EPA makes me worse) and 1 cap of Vitacost Coenzyme B-Complex (not after 3pm)
- Quercetin, Berberine after first few bites of food
- Selegiline (low dose)

For anxiety, the only supplement I've found effective is 500mg Myo-Inositol.


Lia-chan, when in those states I found Olanzapine really helpful when taken at night. Once you've been on that for a bit, if you're still experiencing depression, there's research showing Fluoxetine + Olanzapine (7.5mg) is effective for BPD.

[KieranA001]

Thing I find with me is the cycle is like this: 

 

Low self esteem > feelings of loneliness, self-doubt, negative thinking > depression 

 

I also have anxiety, don't know where it stems from, though. I feel very insecure with people, find it hard to trust them, have no hobbies, ambitions, drive, low motivation and very bad brain fog. 

 

I know with the brain fog though, something that is stimulating or causes anxiety seems to fix it (not sure what it was) but when it went away once I felt anxious the day before.. Like part of my system just woke up. Felt like I downed five red bulls. 

[KieranA001]

I sent of for a T4 test the other day and got my results back today. Here are the results, was wondering if someone could tell me if it's fine:

 

TSH = 1.21 (Normal Range = 0.27 - 4.20) mIU/L

FREE T4 = H22.56 (Normal Range 12-22) pmol/L

 

 

[Elroy]

TSH = 1.21 (Normal Range = 0.27 - 4.20) mIU/L

FREE T4 = H22.56 (Normal Range 12-22) pmol/L

 

By themselves, those results don't indicate anything abnormal.

 

If you have symptoms of hypothyroid, you may not be getting enough peripheral conversion (which is most conversion) of T4 to T3 or high levels of reverse T3 blocking the use of T3. You could try supplementing with 200mcg Selenium (4 brazil nuts) a day to help with conversion.