36 replies to this topic

[Grandmaster]

Since 2014 i have used many nootropics, such as prl 8-53, noopept in powder and pills, huperzine a, l-theanine, phenibut, coluracetam, pramiracetam and few more. Since few months i have a brainfog problem which is very unpleasant one and it makes normal functioning impossible, Energy drinks with 32mg caffeine per 100ml fix this brainfog for me after drinking 200-1000ml of them. Of course energy drinks also contain vitamins b6 and b12, sugar, sometimes also inositol and pantothenic acid. Few beers also seem to remove that brainfog and makes my mind faster, im talking about small-medium doses and not being drunk. How it is possible? Maybe its low dopamine level? Last nootropics i used were noopept and coluracetam which caused severe brainfog after 30mg dose and i stopped used it. Also i tried l-theanine combined with huperzine and vitamins but it worked only once as antibrainfog cure. I thought about buying sunifiram as it is a stimulant and 10mg of it should be much better for health than hundreds grams of sugar and preservatives in energy drinks. Pure caffeine in pills doesnt work for me as good as energy drinks so it may be result of synergy between ingredients. How can i fix this brainfog problem? Sorry for any grammar mistakes or any chaos in my post but its very late and i had to wrote this post since i have some free time now.

[Duchykins]

Don't touch sunifiram.  It's not like the others.

 

So a few beers helps, energy drinks help, but caffeine pills do not help ... 

 

One thing both drinks have in common is a strong carb content.  

 

You can pick up a little tube of glucose tablets for about a dollar at most grocery stores.   Get one and take them, trying to match the glucose content of whatever beers and energy drinks you were having.

 

If nothing happens, then you will have at least eliminated one factor.

Edited by Duchykins, 12 March 2017 - 04:33 AM.

[dopaminerush]

You guys are only looking for masking the problem with untested shit and worsening the situation.

 

Up your sleep quality first. Nothing will work if you dont have good quality and enough amont of sleep, and you should have fully open airways.

 

if you dont have any genetic disorder you might have some b12,iron, testosterone deffiency or something.

 

if you gained weight, just decrease your BF.

[Grandmaster]

You guys are only looking for masking the problem with untested shit and worsening the situation.

 

Up your sleep quality first. Nothing will work if you dont have good quality and enough amont of sleep, and you should have fully open airways.

 

if you dont have any genetic disorder you might have some b12,iron, testosterone deffiency or something.

 

if you gained weight, just decrease your BF.

 

Most of days i sleep around 10 hours, sometimes 8 and very rarely about 4(once a week probably). so  i dont think that this is a problem. I used some b12 and b6 but i run out of b12 i might try use it again cuz i remember some positive effects. Im not sure about iron and testosterone because i had blood test 3 weeks ago and it looked good. Sunifiram was just a thought, i know its very poorly tested so it might be very dangerous(excitotoxicity). Also I dont think that its permament side effect of some nootropic because it passes easily(alcohol,caffeine etc) but its still making me unable to function normally.

[metabrain]

I too noticed this effect but I have a sleep disorder, alcohol reduces REM sleep as do SSRIs so it can actually improve your sleep short term. Caffeine does not keep me awake however here is there interesting thing, I respond to only one energy brand of energy drink, before I figured out what was wrong with me I decided to take its added vitamins separately and then in combinations, it didn't work. It could be a single ingredient or a combination of ingredients such as added colours. I funnily also respond to Skittles, not sure if it is the sugar high or the artificial colouring's but a bag of Skittles perks me up.

[Grandmaster]

I too noticed this effect but I have a sleep disorder, alcohol reduces REM sleep as do SSRIs so it can actually improve your sleep short term. Caffeine does not keep me awake however here is there interesting thing, I respond to only one energy brand of energy drink, before I figured out what was wrong with me I decided to take its added vitamins separately and then in combinations, it didn't work. It could be a single ingredient or a combination of ingredients such as added colours. I funnily also respond to Skittles, not sure if it is the sugar high or the artificial colouring's but a bag of Skittles perks me up.

 

It may be high sugar but since i tested my blood 3 weeks ago and sugar level was 2 times lower than diabetic level i dont think that the source of problem. Also when i tried to use caffeine, b6 and b12 instead of drinking Tiger it didnt work so good as in energy drinks.

[Duchykins]

 

I too noticed this effect but I have a sleep disorder, alcohol reduces REM sleep as do SSRIs so it can actually improve your sleep short term. Caffeine does not keep me awake however here is there interesting thing, I respond to only one energy brand of energy drink, before I figured out what was wrong with me I decided to take its added vitamins separately and then in combinations, it didn't work. It could be a single ingredient or a combination of ingredients such as added colours. I funnily also respond to Skittles, not sure if it is the sugar high or the artificial colouring's but a bag of Skittles perks me up.

 

It may be high sugar but since i tested my blood 3 weeks ago and sugar level was 2 times lower than diabetic level i dont think that the source of problem. Also when i tried to use caffeine, b6 and b12 instead of drinking Tiger it didnt work so good as in energy drinks.

 

 

What beer are you drinking?  Some beers have a modest riboflavin content.  And a lot of energy drinks have a decent chunk of riboflavin too.

[Grandmaster]

 

 

I too noticed this effect but I have a sleep disorder, alcohol reduces REM sleep as do SSRIs so it can actually improve your sleep short term. Caffeine does not keep me awake however here is there interesting thing, I respond to only one energy brand of energy drink, before I figured out what was wrong with me I decided to take its added vitamins separately and then in combinations, it didn't work. It could be a single ingredient or a combination of ingredients such as added colours. I funnily also respond to Skittles, not sure if it is the sugar high or the artificial colouring's but a bag of Skittles perks me up.

 

It may be high sugar but since i tested my blood 3 weeks ago and sugar level was 2 times lower than diabetic level i dont think that the source of problem. Also when i tried to use caffeine, b6 and b12 instead of drinking Tiger it didnt work so good as in energy drinks.

 

 

What beer are you drinking?  Some beers have a modest riboflavin content.  And a lot of energy drinks have a decent chunk of riboflavin too.

 

I drink beer only with friends/at party so its often just lager from local's keg. I think i get same effect from different beers and also wine/wodka(so just alcohol). I might try buying today some b2(riboflavin)

 

[dopaminerush]

btw, it can be porn, masturbation, fantasy addiction  too.  You can try nofap, for some guys it can get worse at the beginning but after turning into normal human being, life and brain is completly changing.

 

you can try intermittent fasting 

 

 

it can be a low blood sugar issue, some guys have very high insulin sensivity and this can cause a  hypoglycemia  specially when you wake up in the morning, you can get palpitations and you blood sugar cna go 60 to 95 very fast for lack of glucose and drop back to low levels.

 

 

 

Edited by dopaminerush, 13 March 2017 - 10:10 AM.

[Grandmaster]

btw, it can be porn, masturbation, fantasy addiction  too.  You can try nofap, for some guys it can get worse at the beginning but after turning into normal human being, life and brain is completly changing.

 

Do you suggest something with this statement? Lol. I dont think neither low or high sugar level because morfology showed that my sugar level is rather ok(2 times less than diabetic as a i wrote before).

Edited by Grandmaster, 14 March 2017 - 01:23 AM.

[Kabb]

I had a response very similar to that which Grandmaster describes.  After many years of decline it looks as if I have a problem with adequate energy production in my mitochondria and the symptoms this causes are extremely unpleasant with daily states of cognitive confusion.  Google "MELAS" for info on my condition.  As the mitochondrial energy chain falters and stumbles it can have further knock on effects on other systems (such as fatty acid oxidation) which have their own symptoms and own treatments which contributes to a complicated set of symptoms.

 

Grandmaster may want to consider experimenting with supplements known to help the main mitochondrial energy chain to see if they help with the brain fog.  If it was me I would consider trying one or more of the following:

 

(1) 100mg of good quality CoQ10 (I prefer the ubiquinol form but it is expensive and some people suggest it offers little improvement over ubiquinone).  This can be expensive.

(2) A cheaper but effective supplement is 100mg to 200mg alpha lipoic-acid.  (I find the general R-S form is better than the pure R-form).  

(3) Two grams of creatine monohydrate is the cheapest of all and it proves effective for me.  

(4) A B-complex (such as "100") is also useful but ideally needs re-dosing through the day which might cause an overdose of folic acid in some people.

 

Caffeine is also good up to 300mg per dose.

 

I found alcohol worked best many hours after I stopped drinking.  Say 3 hours after drinking 2 pints beer.  My theory is that they alcohol provided cellular energy as well as vasodilation in the brain which provided the mitochondria with more energy to houseclean themselves but the process took a few hours to achieve.  That's just my 2 cents worth of speculation.

 

Very light exercise (gentle walking 0.5 to 1 mile) also helps clear the fog.  Maybe starting half to one hour later but not lasting more than an hour or two.  Perhaps the extra load from walking makes the mitochondria work better in order to cope with the physical exertion and maybe they don't switch off immediately afterwards.  

 

 

Edited by Kabb, 18 March 2017 - 12:51 PM.

[gamesguru]

Low dose alcohol is just a nootropic stimulant[1], that's why light drinkers perform better on cognitive tests than non-drinkers.

 

But you're onto something surely with the B vitamins.  And being so clever, you must also surely have a suspicion that energy drinks are an inferior source to many common foods?

 

As for the coffee vs pure caffeine pills, it has to do with caffeoylquinic acids and other non-caffeine compounds within coffee.

With tea it is commonly acknowledged that there is theanine and catechins and a world of effects yet to be explored, but with coffee the common conception is if you decaffeinate it you remove it of all psychoactivity.  And this is easily disproven.

 

The cross tolerance between tea and caffeine is not so great, because they affect dopamine in different regions.  Therefore you can alternate them, or if you are a regular tea drinker you can just order a coffee one day and really appreciate a different and stronger buzz.

Food Chem Toxicol. 2012 Feb;50(2):390-8. doi: 10.1016/j.fct.2011.09.041. Epub 2011 Oct 13.

Identification of coffee components that stimulate dopamine release from pheochromocytoma cells (PC-12).

Walker J¹, Rohm B, Lang R, Pariza MW, Hofmann T, Somoza V.

 

Coffee and caffeine are known to affect the limbic system, but data on the influence of coffee and coffee constituents on neurotransmitter release is limited. We investigated dopamine release and Ca(2+)-mobilization in pheochromocytoma cells (PC-12 cells) after stimulation with two lyophilized coffee beverages prepared from either Coffea arabica (AR) or Coffea canephora var. robusta (RB) beans and constituents thereof. Both coffee lyophilizates showed effects in dilutions between 1:100 and 1:10,000. To identify the active coffee compound, coffee constituents were tested in beverage and plasma representative concentrations. Caffeine, trigonelline, N-methylpyridinium, chlorogenic acid, catechol, pyrogallol and 5-hydroxytryptamides increased calcium signaling and dopamine release, although with different efficacies. While N-methylpyridinium stimulated the Ca(2+)-mobilization most potently (EC(200): 0.14±0.29μM), treatment of the cells with pyrogallol (EC(200): 48±14nM) or 5-hydroxytryptamides (EC(200): 10±3nM) lead to the most pronounced effect on dopamine release. In contrast, no effect was seen for the reconstituted biomimetic mixture. We therefore conclude that each of the coffee constituents tested stimulated the dopamine release in PC-12 cells. Since no effect was found for their biomimetic mixture, we hypothesize other coffee constituents being responsible for the dopamine release demonstrated for AR and RB coffee brews.

[metabrain]

I know what you are going through, I suffer from severe memory issues and fatigue, it took me a long time to figure out the issue but I have learned a lot, you need to first get very scientific and methodical about how you approach an unknown condition, it isn't good enough to simply take something and hope it works you have to understand how it basically works.

 

When someone says they are suffering a certain issue I always say check the baseline before trying nootropics because you could spend a fortune on a nootropic solutions (as I did) when it could be something simple medically. Doctors always start off at the basics too because they can isolate medical issues in a surprising way. So rule out the basics.

 

Are you sleeping at night? Does it take ages for you to sleep? Do you do anything strange in your sleep? Do you feel refreshed during the day?

 

Are you stressed. Any anxiety?

 

Any other health issues other than brainfog,no matter how minor? 

 

How much exercise do you get and what is your diet like?

 

Do you smoke, drink much, take drugs or have a history of drug use?

 

Any head injuries or seizures?

 

Have you had a full set of blood panels (not just the basic set), they rule out basic things like thyroid issues, t-levels etc.

 

Are you allergic to anything?

 

You have tried a range of vitamins, minerals, amino acids and some nootropics but no luck. If you eat well you are unlikely to be deficient. If you have an unusual absorption issue it mainly presents with other symptoms.

 

I normally do recommend trialling medications with a doctor, SSRIS, SNRIs, they aren't just for the depressed, they can be used against a range of illness. I used one to help isolate my issues. They are generally unpopular here because they make you sick and they take time to have an affect, they have strong bindings and can be used to isolate issues, they bind to various receptors and in various different ways, choose one that is generally more stimulating and good for memory,  if it lifts your brain fog after a month or so you can isolate from there or try another with a different binding (you can move from one to another but you must give yourself a day or two to reduce the serotonin)

You will find many Nootropics are simply medications, herbs etc with weak bindings to various neurotransmitters or alter neurotransmitters in some way. Every persons neurochemistry is different, what works for you may not work for another or have the opposite effect.

 

Have is a chart of bindings for SSRI/SNRIs http://www.preskorn....s/9909_fig1.gif

 

Here are some popular medications you could try

Lexapro - Affinity at 5-HT1A. Generally good for sociability and poor at memory however it might cause you to rebound once you come off it after a month.

Sertraline has affinity for 5-Ht2C at all ranges and DAT2 at 100mg (dose is 50mg to start so you build up to 100mg) (I would not recommend this as your first SSRI)

Citalopram - Generally quite mild. I recommend starting with this one.

Fluoxetine - A large binding range

Fluvoxamine - I recommend this one for you as a second option.

Buproprion (NDRI) - Affinity for nicotinic acetylcholine receptors

SNRI - Ask doctor for something decent for memory, I have very little experience with this range.

 

Edited by metabrain, 18 March 2017 - 11:11 PM.

[Grandmaster]

Thank you for all the answers, i will try to do as much as i can at the moment and give feedback

[Ames]

If you have brainfog, the racetams should be the last supps that you take imo. You don't want to be downregulating or otherwise throwing off any exicitatory neurotransmitters. This will only make your problem worse.

 

Similarly, cut out all GABA-ergic supps. Ever see someone on high dose xanax? Now that's brainfog. You want to be clearer, not foggier. Thus, no GABA stims.

 

Energy drinks mostly supply you with the RDA of B vits plus caffeine - sometines from unique sources that imply probable unique alkaloids in the caffeine extract. I feel caffeine more from Energy Drinks than I do coffee. You could try buying powdered Guarna extract, for instance, if you enjoy energy drink stimulation.

 

All energy drinks tend to contain Inositol. I find Inositol to give me anti-nootropic problems with memory. Thus, I can only indulge in energy drinks so frequently without realizing such issues from the included Inositol.

 

Many energy drinks (ie: Rock Star) include Milk Thistle. Milk Thistle causes anxiety over time, in my experience, that is difficult to reduce. Thus, I look for Energy Drinks without it (Monster).

 

If I were you, I'd look for caffeine from unique sources, like guarna, and look into supplementing select B vitamins. I mostly recommend high dose (2g/day) B1 supplementation with occasional low dose B2 supplementation. B6 tends to be too strong to mess with, imo, if you have an issue that you are trying to tweak. Hydroxycobalamin (B12, 1 mg) plus Methylfolate (B9, .2 mg) tends to clarify and stimulate the mind. You could try this combination as a separate stack away from everything else. It's potent, and so i recommend evaluating it without other supps added in.

Edited by golgi1, 24 March 2017 - 07:38 PM.

[Grandmaster]

If you have brainfog, the racetams should be the last supps that you take imo. You don't want to be downregulating or otherwise throwing off any exicitatory neurotransmitters. This will only make your problem worse.

 

Similarly, cut out all GABA-ergic supps. Ever see someone on high dose xanax? Now that's brainfog. You want to be clearer, not foggier. Thus, no GABA stims.

 

Energy drinks mostly supply you with the RDA of B vits plus caffeine - sometines from unique sources that imply probable unique alkaloids in the caffeine extract. I feel caffeine more from Energy Drinks than I do coffee. You could try buying powdered Guarna extract, for instance, if you enjoy energy drink stimulation.

 

All energy drinks tend to contain Inositol. I find Inositol to give me anti-nootropic problems with memory. Thus, I can only indulge in energy drinks so frequently without realizing such issues from the included Inositol.

 

Many energy drinks (ie: Rock Star) include Milk Thistle. Milk Thistle causes anxiety over time, in my experience, that is difficult to reduce. Thus, I look for Energy Drinks without it (Monster).

 

If I were you, I'd look for caffeine from unique sources, like guarna, and look into supplementing select B vitamins. I mostly recommend high dose (2g/day) B1 supplementation with occasional low dose B2 supplementation. B6 tends to be too strong to mess with, imo, if you have an issue that you are trying to tweak. Hydroxycobalamin (B12, 1 mg) plus Methylfolate (B9, .2 mg) tends to clarify and stimulate the mind. You could try this combination as a separate stack away from everything else. It's potent, and so i recommend evaluating it without other supps added in.

 

Im going to buy some B1 today since it may be part of a problem, also i think you meant 2mg of it per day am i right? Overdosing this vitamin is nearly impossible since even 50mg doses or higher are still safe. Interesting this is i feel much more better at night, it seems i think faster and have no brainfog + more creative.
 

[Keizo]

If your neck area is stiff this can cause brain fog, and in severe cases vertigo. You might not have this problem, but I had a very stiff neck region which caused brain fog and some mild vertigo and I had no idea it was (to a significant extent) because of muscle tension. 

The simplest thing I have found helpful is in this video

youtube.com/watch?v=_XlxMuuGIvI

If this is your problem, what has worked for me and I hear has worked for many as a more long-term solution, is to improve ones posture as well as exercising more frequently. Massage and so forth can also help of course.

 

I have also found that many nootropics tend to make this region of musculature stiffer for me, at time, which I guess isn't surprising considering they often have effects regarding acetylcholine. With nicotine induced neck stiffness I have found that tyrosine sometimes works fairly well short-term to alleviate the stiffness (as did low doses of prescription stimulants).

 

Edited by Keizo, 26 March 2017 - 02:15 AM.

[Keizo]

I have also given up on most purported nootropics because of problems with brain fog (and no adding a bunch of choline only worsens the problem for me). I now stick to tried and true pharmaceuticals almost entirely (methylphenidate, cerebrolysin, selegeline, etc, of course not at the same time!)

Edited by Keizo, 26 March 2017 - 02:17 AM.

[Grandmaster]

Bought today vitamine B complex with b2,b1,b5 and few more - it may be solution. I have wondered if it may be a permament brain damage but i havent used neither super big doses or dangerous nootropics...I used noopept for a long time (around 8-10g i think) so it may be source of problem. I try to use sugar as rarely as possible but my sugar level in blood was just a little bit higher than normal(mine was 105.  max is 99 and diabetic level is 200) so i dont think it would cause so massive brainfog.

[gamesguru]

You may just be hyperacetylated/methylated and choline-sensitive (choline sensitivity is often reported in anxiodepressive states, and a polymorphism of nicotinic receptors is a common cause of such sensitivities).  Compounds active at nicotinic sites include rhamnetin (flavonoid in cloves), quercetin (flavonoid in red onions, chocolate and cranberries), 1-acetamidoquinolizidine (secretion of poison dart frog), buproprion (pharmacologic agent), phytocannabinoids and exercise.  The nicotinic sites are really fascinating little buggers, as I believe it with pivotal roles to be characterized in every major mental condition.  Maybe tinker a bit with the suggestions to see if anything works?

 

I would not necessarily swear off common noots.  If adding choline makes you worse, consider restricting sources (such as eggs, nuts and meats).  It is only in the presence of choline (precursors) that AChEs (enzyme inhibitors) will lead to a runaway effect.  If there's no ammo to load your rifle, your trigger can't get stuck in burst mode.  With a relatively weak cholinergic like ginkgo, the body adjusts overnight and the much stronger dopamine modulating effects can begin to be enjoyed.

[Grandmaster]

I started to take ginkgo but not much effect as one have to take it for at least few weeks to notice improvement.  Summing up:

-b2 and magnesium seems to help but not everyday

-i feel much better at night, better memory, more creative and more enjoying music

-since i started to take magnesium and vitamins energy drinks have much smaller effect on me

-after waking up but still laying in beed i feel same as at night but start to feel foggy and unmotivated after couple of minutes when i get up and for example make breakfast

-i have daily physicial activity, 2-3 hours a day and feel better after doing it

-i have days of absolute brilliancy mixed with days of foggy "wandering"

Should i visit a doctor or we can solve this basing on all informations that i have included?

[gamesguru]

ginkgo has like bi-phasic effects, a short and a long beat.  you get benefits from day 1, but those are the same ones that only last as long as the ginkgo is in your system and the ones that you get tolerance to after 4-5 days.  there are also benefits that take weeks or months to accumulate but are not subject to tolerance concerns, and which graciously linger for days to weeks after your last dose

 

i wouldnt take magnesium EVERY day anyways, maybe 4-5 out of the week.  more realistically, its 3

 

you can try alternating tea and coffee, they affect dopamine very differently, and the caffeine cross tolerance doesnt act like you would expect

 

are you still having eggs for breakfast??  are you eating consistently?  does fasting make you worse?  should probably enlist the help of a licensed fellow just to be safe..

Edited by gamesguru, 05 April 2017 - 06:35 PM.

[Kabb]

I started to take ginkgo but not much effect as one have to take it for at least few weeks to notice improvement.  Summing up:

-b2 and magnesium seems to help but not everyday

-i feel much better at night, better memory, more creative and more enjoying music

-since i started to take magnesium and vitamins energy drinks have much smaller effect on me

-after waking up but still laying in beed i feel same as at night but start to feel foggy and unmotivated after couple of minutes when i get up and for example make breakfast

-i have daily physicial activity, 2-3 hours a day and feel better after doing it

-i have days of absolute brilliancy mixed with days of foggy "wandering"

Should i visit a doctor or we can solve this basing on all informations that i have included?

 

Those days of "absolute brilliancy" indicates your potential but you are not reaching it often enough.  That coupled with clarity late at night suggests it may be worth taking a look at one of the fatty acid oxidation disorders.  Although briefly abstaining from food will prevent toxins in a FAOD, overnight fasting often brings its own problems.

 

Also linked to food are the organic acidemias (which implicate defective protein metabolism of ingested food) and these too may be worth checking out.

 

As a very crude test for several of the FAODs, it might be worth seeing if 3 or 4 grams daily of l-carnitine (in 1 gram divided doses on an empty stomach) has any effect 1 or 2 hours later.  L-carnitine acts as a transporter of certain fatty acids to help release their energy benefit and l-carnitine also acts as a scavenger of uncleared toxins although, in certain medical conditions, l-carnitine stores are excreted while performing this task.

 

These sorts of condition are not common and are often overlooked entirely.  There are dozens of other energy-depletion conditions but your night time clarity made me think of a food connection.

 

 

PS:  Your highly beneficial response to alcohol may reflect the ability of ethanol to take an alternate pathway to supplying cellular energy.  It is not diagnostically useful as there are so many other effects it also causes such as vasodilation, addressing GABA(A) receptor malfunction during withdrawal, dopaminergic properties, etc.

 

 

 

 

 

Edited by Kabb, 06 April 2017 - 01:08 PM.

[gamesguru]

If that's the case a diet high in antioxidants can offset the disease greatly.  Ginger, blueberries and tea are among the most effective.  They specifically target Arachidonic acid.  see a study from 1984 'Aqueous extracts of onion, garlic and ginger inhibit platelet aggregation and alter arachidonic acid metabolism.'  And a more recent study concluded, "Dietary ginger phytochemicals target cholesterol metabolism and fatty acid oxidation in mice, with anti-obesogenic but also hypercholesterolemic consequences."

 

I would be leery though if you have anything like lyme disease because those bacteria can also benefit from enhanced fatty acid transport.

[Grandmaster]

Thanks for all the posts. I gonna visit a doctor i think since there is little chance i can fix this brainfog by myself. Maybe you have any other suggestions? Dosing noopept for a long time with some other nootropics cant be source of problem? Noopept havent worked for me well anyway, maybe slight long term memory enchancement.

Also i thought about one thing - i may feel better at night/late evening since im sitting and listening to music, im fairly tall so may it be blood cirulation issue?

Edited by Grandmaster, 08 April 2017 - 08:45 PM.

[Grandmaster]

Few days ago i again did complete blood count including vitamine b12, potasium, iron, TSH and everything is perfect - no deficency or too high level of anything in my blood including glucose. I think it may be acetylcholine problem or dopamine deficiency. I found out that one of the  best ways to increase dopamine level is to use l-tyrosine or its more absorable version - acetyl-l-tyrosine.  Also for some people dosing l-tyrosine removed depersonalization problem with im sometimes struggling with. If we dont take as a option that this brainfog is a result of a brain damage made by long term using of noopept or ocassionally couluracetam,prl 8-53,pramiracetam,phenibut etc.  What do you think?

[gamesguru]

how on earth is it one of the best ways to improve dopamine function?  tyrosine is associated with melanoma similar to the case of 5-htp and mitrial fibrosis.  so i wouldn't just go taking it think youre doing yourself a favor..  further, the acetylated version is dangerously well-absorbed to the point of raising receptor downregulation concerns.  even though ginkgo (horny goat weed too) doesn't permeate the brain as well, isnt as potent, it may still be better to go with a weak overall modulator than a powerful targeted approach [most people won't benefit, but maybe for some severe adhd it could be recommended in place of straight amphetamine]  Well, i can't explain how else the tolerance with tyrosine would be so much more tenacious than with ginkgo.  i wouldn't throw away your bottle however... tyrosine does work alright for a cram session or important exam, when you take it here or there, early in the morning on an empty stomach, but it doesn't work nearly as well as amphetamines when you start taking it all the time.  the tolerance develops within a matter of days so i'm afraid you'll find altogether no reason for its inclusion in your daily regimen.  so you return to square one in your quest to uncover promising dopaminergic supplements...

[Grandmaster]

how on earth is it one of the best ways to improve dopamine function?  tyrosine is associated with melanoma similar to the case of 5-htp and mitrial fibrosis.  so i wouldn't just go taking it think youre doing yourself a favor..  further, the acetylated version is dangerously well-absorbed to the point of raising receptor downregulation concerns.  even though ginkgo (horny goat weed too) doesn't permeate the brain as well, isnt as potent, it may still be better to go with a weak overall modulator than a powerful targeted approach [most people won't benefit, but maybe for some severe adhd it could be recommended in place of straight amphetamine]  Well, i can't explain how else the tolerance with tyrosine would be so much more tenacious than with ginkgo.  i wouldn't throw away your bottle however... tyrosine does work alright for a cram session or important exam, when you take it here or there, early in the morning on an empty stomach, but it doesn't work nearly as well as amphetamines when you start taking it all the time.  the tolerance develops within a matter of days so i'm afraid you'll find altogether no reason for its inclusion in your daily regimen.  so you return to square one in your quest to uncover promising dopaminergic supplements...

 

I havent bought it yet, i just consider it as a one of possibilites...I also thought about curcumin and theanine but since i used supplement that had l-theanine and didnt give me any procognitive effect i rather consider only acetyl-l-tyrosine and curcumin.

[Grandmaster]

Tyrosine seems to help but taking it everyday is not a good idea since when i did it for 4 days in a row it started giving noticeable foggy-like depersonalization effect. Also after using lecithin, vitamins and ginkgo energy drinks stopped working like they did before but brainfog i still present, It shows up sometimes after walking or intellectual effort and is basically rarely present at night and evening (21 and up) , only in the morning and afternoon... As i wrote i had complete blood count and everything looked fantastic even vitamin b12 and glucose. Im really looking for help since i have paid for private doctor visit and it didnt help me at all - doctor seemed to have less knowledge about neurotransmitters and cogitive impairment than i had

[gamesguru]

i told you tyrosine is no good.  and the ginkgo you can only get away with 3-4 days a week if that.  otherwise you got tolerance issues, as you saw.  mix it up bubba, example.... ginkgo and tea one day, ginseng and magnesium the next, gotu kola and blueberries / chocolate a third, then repeat.  i typically do tea every day, magnesium and ginkgo 2-3 days per week and ginseng 1-2.  and don't forget that throwing in little stuff like royal jelly and quinoa can make the difference between getting thru the day and not.  if it's not immulogic, it's probbaly neurologic, the fatigue i mean.  how do you respond to dopamine stuff like ginkgo and tea?  sometimes doctors have limited experience, other times you don't present the full story to them