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[brosci]

I eat a pretty vegetable-rich, low-meat diet.  I've also got the full homozygous MTHFR C677T, MTRR A664A, & MTR A66G polymorphisms.  From what I understand, I should benefit from b12 & folate supplementation.

 

While taking 1mg of methyl-b12 and 800 mcg of methyl-folate per day, my last serum B12 test came back around 1300 pg/mL -- the reference range for normal healthy individuals is 211-946 pg/mL.  I avoided supplements the day before my blood test and fasted for 24hrs before the blood draw.

 

Is this a sign that I might be supplementing too much b12?  Or, is this a sign that I'm not metabolizing this b12 very well?  Or, is this benign or possibly a hint of something else that I could follow up with (low GSH?)

Edited by brosci, 19 March 2017 - 11:51 PM.

[pamojja]

Though I didn't do genetic testing, in my experience my homocysteine was through the roof if my serum B12 was in the normal range. Only came down closer to 2000 pg/ml. Only tested Glutathion peroxidase twice and both times was in the upper half of normal.