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My genetic testing results - methylation questions

methylation genetic

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#1 Omega 3 Snake Oil

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Posted 24 March 2017 - 01:56 AM


At the advice of my internist I had a genetic test done, focusing on five areas: mental health/mood and behavior, cardio health, methylation, metabolism and diet, and detoxification. My internist's main reason for recommending this was his suspicion I have poor methylation genes due to my persistent neurological Lyme symptoms.

I met with the geneticist who devised the test. Lo and behold, I have poor meth. genes at most of the positions tested. The other areas of the test were interesting if not surprising. But the geneticist said he believes beyond a doubt that poor methylation is the root of my problem. He says my genes were a tinderbox and Lyme was the spark that lit the fire.

My internist reviewed my genetic report and thinks I should go on B12 sub-q shots, plus a green juice diet, plus sublingual B12 and B9 (folate), both in methylated form. Both doctors agree I'm one of the four or five worst meth. profiles they've ever seen, out of 400+ patients they've given the test to.

Here are some of my relevant genes. Any and all feedback is welcome, I'm kinda lost here and desperate to get better.

FUT2
Rs602662

A/G: Associated with moderate/possibly suboptimal enzyme function
and plasma cobalamin levels

 

MTHFR
Rs1801133

 

C/T: Associated with optimal enzyme function and 5-MTHF production
Associated with moderate (30 to 35 percent reduction of) enzyme
activity with intermediate 5-MTHF production

SHMT1
Rs1979277

G/G: Associated with optimal/moderately reduced bioavailability of
cytosolic 5-MTHF and efficient/moderately reduced homocysteine
to methionine conversion (please note connectivity to MTHFR)

MTR
Rs1805087

A/G: Associated with moderate enzyme activity with intermediate
conversion of homocysteine to methionine

MTRR
Rs1801394

G/G: Associated with suboptimal enzyme activity and suboptimal/poor
re-methylation of cobalamin to methylcobalamin
(potentially reduced bioavailability of methyl B12)

MTHFR
Rs1801131

A/A: Associated with optimal enzyme function and 5-MTHF production


Five out of six are suboptimal.







Also tagged with one or more of these keywords: methylation, genetic

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