6 replies to this topic

[bkaz]

https://www.scienced...70323141340.htm

 

Sinclair: "While resveratrol activates SIRT1 alone, NAD+ boosters activate all seven sirtuins, SIRT1-7, and should have an even greater impact on health and longevity," 

Edited by bkaz, 24 March 2017 - 12:47 PM.

[SearchHorizon]

I am a bit skeptical that NMN precursors (while being helpful for one's overall health), is the major fix for aging effects.

 

Why aren't we seeing multi-fold increase in animal lifespan in experiments with NMN precursor treatments? My answer - probably because, ultimately, NMN precursors only address the downstream effects and not the source of the problem.

[to age or not to age]

Beta lapachone appears to be the next generation of NAD enhancers, as it impacts the NMQ01 gene, and there NAD ratio. I gave a sample of it to David S,

and I will quote what he said to me: ' This is a very interesting compound"

[PeaceAndProsperity]

Beta lapachone appears to be the next generation of NAD enhancers, as it impacts the NMQ01 gene, and there NAD ratio. I gave a sample of it to David S,

and I will quote what he said to me: ' This is a very interesting compound"

He might patent it and sell it back to you.

 

[mrkosh1]

Sulforaphane and R-ALA both activate NQO1 as well. These should both be tested with NR.

 

 

 

[RWhigham]

Nrf2_stack       Nrf2->NQO1->NAD+    may raise NAD+ baseline

  BroccoMax 2cap Sulforaphane 16mg  -myostatin/BP/Cancer_w/o_NAC +Nrf2 syn

  Andrographis 1 cap 400mg 10% andrographolides (40mg) +Nrf2

  Curcubrain 1cap 400mg -amyloid/tau/NF-kB/oxLDL/CoA/iron/TOR1/TSH +Nrf2 syn

  EGCG 1cap 120mg -Tau -NF-kB -cancer -cortisol -ATP -libedo +NrF2 syn

  Feverfew Swanson 1cap 500mg 0.5% parthenolides (2.5mg)   +Nrf2

 

Listed in order of potency  (sulforaphane is the most potent)

Sulforaphane, Curcumin, and EGCG are synergistic. EGCG by itself has little effect on Nrf2

http://anti-agingfir...ls.com/?s=Nrf2 

 

 

[William Sterog]

Nrf2_stack Nrf2->NQO1->NAD+ may raise NAD+ baseline
BroccoMax 2cap Sulforaphane 16mg -myostatin/BP/Cancer_w/o_NAC +Nrf2 syn
Andrographis 1 cap 400mg 10% andrographolides (40mg) +Nrf2
Curcubrain 1cap 400mg -amyloid/tau/NF-kB/oxLDL/CoA/iron/TOR1/TSH +Nrf2 syn
EGCG 1cap 120mg -Tau -NF-kB -cancer -cortisol -ATP -libedo +NrF2 syn
Feverfew Swanson 1cap 500mg 0.5% parthenolides (2.5mg) +Nrf2

Listed in order of potency (sulforaphane is the most potent)
Sulforaphane, Curcumin, and EGCG are synergistic. EGCG by itself has little effect on Nrf2
http://anti-agingfir...ls.com/?s=Nrf2

Rhodiola may also worth taking:

https://www.ncbi.nlm...pubmed/26577463

https://www.hindawi....cl/2015/876825/

I have found similar benefits in Rhodiola and Sulforaphane that could be both related to Nrf2 upregulation. They are two of the three supplements that make me look considerably better. The third, spirulina, interestingly is classified also as a Nrf2 activator in this papper:

https://www.ncbi.nlm...les/PMC3958930/