2 replies to this topic

[Chee Hong Tart]

It's just two different companies applying their own patent or are totally 2 different drugs?

[jaiho]

Different drugs, both SSRIs.

Fluvoxamine isn't used as much nowadays, Fluoxetine (Prozac) is far more popular and probably slightly more efficacious.

 

[Xptriate]

From memory, so beware:

Most evident difference is that fluvoxamine is actually a Sigma 1 agonist, and raises neurosteroids in that way.

Fluoxetine has much lower affinity for Sigma 1, if any, and raises neurosteroid Allopregnanolone by increasing the affinity of 3alpha-HSD 100x fold to its substrate 5alpha DHP.

Edited by Xptriate, 15 April 2017 - 03:44 AM.