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[vader]

I have trialed fluvoxamine for a few days. The sides were too much to handle for me, nausea, 3 - 4 hours after dosing somnolence, muscles were achy and heavy. Overall I've felt worse than ever. And this was with just 25mg. Could also be related to dropping caffeine for the treatment, because of hepatic inhibition of caffeine clearance induced by fluvoxamine.

 

Which points me to either it being somewhat sigma-ergic in nature (fluvoxamine is a potent sigma agonist). Now I've felt some positives (stronger eye contact), but the dysphoric effects were just too intense and i've nixed it for now.

 

Would sertraline be a better fit (with it's sigma antagonism)?

Edited by vader, 28 March 2017 - 06:52 PM.

[gamesguru]

Doctors are like car mechanics, not always honest.  I didn't respond too well to SSRIs either.  Ginkgo, with its preference to dopamine over serotonin and its mild opioid antagonism, was a solid choice.  What would you attribute the eye contact to though?

 

I would definitely let the caffeine withdrawals pass and then try again.  

Symptoms. Caffeine withdrawal can bring on headaches and problems concentrating. You might feel weak because caffeine withdrawal can cause fatigue and mimics many flu-like symptoms. Common problems include muscle stiffness and soreness, nausea, vomiting, irritability and depression.

 

If that doesn't work, I would potentially consider cytisine, buproprion, chantix or any other nicotinic drug.  Many people with a peculiar set of nicotinic receptors are non-responders to SSRIs[1] [2].. NAChRs are co-localized on 5-ht3 sites.  They also feed into the dopamine and GABA-B systems, which are closely related to anhedonia.  Coincidentally chantix is also a 5-ht3 agonist (which gives it its nauseating and mildly psychiatric properties)