Posted 04 April 2017 - 12:35 PM
I've discovered that taking msm seems to ameliorate some of the symptoms I experience like fatigue, irritability, flat affect and so on. This is not conclusive and maybe it shows that like always it's not the same every day. Like l-theanine, that on some days ameliorates symptoms of increased serotonin activity and on other days causes them (something something glutamate).
Posted 10 April 2017 - 09:50 AM
Any studies to back this up? It does cross the blood brain barrier.
I'm taking 1,5 grams of MSM along with 1 gram of Glucosamine for joint health, but I feel like there is something mental going on too. I'm taking plenty of stuff though so can't say for sure.
Posted 10 April 2017 - 11:22 AM
Any studies to back this up? It does cross the blood brain barrier.
I'm taking 1,5 grams of MSM along with 1 gram of Glucosamine for joint health, but I feel like there is something mental going on too. I'm taking plenty of stuff though so can't say for sure.
I'm not good with finding studies sadly. But yes it does do something mental. It improves mental clarity and mental focus and perhaps mental energy too?
Posted 10 April 2017 - 01:08 PM
Yeah, clarity and focus - my vision and my mind is crystal clear right now and I think MSM is contributing to it, perhaps more than I thought. My afternoon tiredness has decreased lately too. You may be on to something here. But I wouldn't say it's clearly anti-serotonergic, perhaps a modulatory action. I bet it does something for glutamate too. Needs further investigation.
Posted 10 April 2017 - 01:53 PM
Yeah, clarity and focus - my vision and my mind is crystal clear right now and I think MSM is contributing to it, perhaps more than I thought. My afternoon tiredness has decreased lately too. You may be on to something here. But I wouldn't say it's clearly anti-serotonergic, perhaps a modulatory action. I bet it does something for glutamate too. Needs further investigation.
Serotonin and glutamate interact peculiar ways. Hypo and hyperfunction, and something else, of the nmda receptor can lead to hypersensitivity to serotonin as seen in schizophrenia and autism - two polar opposite disorders in terms of nmda functioning (yes, I know, some schizophrenics bla bla bla).
Like with l-theanine, sometimes it clearly reduces serotonin, especially if taken in conjunction with creatine or caffeine (creatine has an odd relationship with serotonin likewise, doses under 6 or so grams decrease serotonin according to studies while higher dosages increase serotonin), while other times l-theanine increases serotonin significantly.
Perhaps msm interacts with glutamate in ways similar to nitric oxide modulating supplements like agmatine. Or perhaps it does the polar opposite of nitric oxide in terms of effects on glutamate, that would actually make more sense.
Anyway I've tried doses up to 15g and all I can say is that it probably increases heart rate. Not sure if it matters for joint flexibility whether you take 1g or 15g.
Posted 10 April 2017 - 01:57 PM
Thank you both for mentioning this. I was not aware of this substance and it has some promise for snoring and hair growth (topical use). I'm keenly interested in both. mental benefits would be a plus.
http://www.koreascie...200922335514801
Blum, JM; Blum, RI (2004). "The effect of methylsulfonylmethane (MSM) in the control of snoring". Integrative Medicine. 3 (6): 24–30. (somehow, i can't find this article online)
BTW, does it give body odor like some other foods with sulfur (garlic onions, etc).
Posted 10 April 2017 - 06:23 PM
Blum, JM; Blum, RI (2004). "The effect of methylsulfonylmethane (MSM) in the control of snoring". Integrative Medicine. 3 (6): 24–30. (somehow, i can't find this article online)
i found a detailed patent on this: https://www.google.c...tents/US6440391
looks like the MSM powder is cheap on Amazon. will order and try it.
Posted 13 April 2017 - 09:59 PM
It's not only msm that appears to have mental/brain effects but it's also glucosamine. There's something to glucosamine that's a bit hard to put my finger on, maybe a more clear mind, maybe mild anti-depressive properties? Not really sure but not taking it seems to make a clear difference. I used to take it with vitamin C because I had purchased it for my relative who had knee problems but he complained of heart-related side-effects.
Posted 14 April 2017 - 07:18 AM
Examine.com doesn't reveal any neurological effects for neither supplement. But I agree both do something, maybe synergistic effect. 1500 mg of Glucosamine was comparable to 3000 mg acetaminophen, so analgesic action is definitely there. I'm finding them anxiolytic, something similar to taurine in that regard, and a sharp mind. Perhaps they lower inflammation which itself can provide relief from depression for many.
Posted 14 April 2017 - 03:25 PM
I read that msm + vitamin C have a synergistic effect on various things so I tried a little over 2g of msm and 1g of vitamin C and holy smokes the headache and dizziness I have. Could msm interact with the nitric oxide system? That could very well explain some of its mental effects since nitric oxide interacts with a lot of neurotransmitters. At least vitamin C appears to do so. If I find another cause of the headache then I will update.
Edit: I have tried vitamin C + msm before but only with 500mg vitamin C to counteract some of the twitching and other glutamate related effects of fasoracetam.
My stack was fasoracetam 10mg + vitamin C 500mg + some less than 100mg of l-theanine and some 1-10g msm. Didn't have a headache before. This time, today, I only took msm + VC.
Edited by PeaceAndProsperity, 14 April 2017 - 03:27 PM.
Posted 16 April 2017 - 08:32 AM
I'll add vitamin C too. I've also heard about the synergism and support for collagen production. Actually I'm going to take 1 gram now and see what happens.
Anyways, some anti-inflammatory or other health benefit must be happening with Glucosamine + MSM, it's dramatically keeping my chronic acne in check. And that shit has been resistant to both accutane and antibiotics.
Hey PeaceAndProsperity, why do you have such a bad reputation? You seem to have some interesting postings, maybe personal style sure but some good stuff and findings there regardless.
Posted 16 April 2017 - 11:51 AM
One single guy did that to me 
anyway this isn't reddit so who cares
I see that myprotein is selling msm + glucosamine + chondroitin. could it be that this combo has the same effects as they individually have on cognition? unless advised not to ill give the product a go
Posted 17 April 2017 - 08:27 AM
Well that sucks, bad rep under your nickname can give impression of a not-trust-worthy poster and people may not take your posts seriously or skip them entirely. Maybe you could ask a moderator or administrator to reset it.
I don't see why that combo wouldn't work as well as each separately - if anything there could be nice synergy.
I wonder if buying in bulk would make this cheaper. I can get 1 kilo of MSM powder for 15 euros, and 400 x 1g of Glucosamine costs $22,49. I just hate playing with powders since I already have plenty of them like creatine, protein, superfoods, herbs, nootropics. Hence a capsuled combination supplement is much nicer.
edit: I'm checking PureBulk and the prices are very cheap as powders. Unfortunately the shipping costs to Finland are over 20$.
Edited by Galaxyshock, 17 April 2017 - 08:45 AM.
Posted 17 April 2017 - 12:24 PM
Can it cause paralysis? I seem to have more difficulty walking after taking it.
Not likely, it's an extremely nontoxic substance, and esp. in the amounts you are likely taking...
ORAL TOXICITY (rat LD50): 5,000 mg/kg
DERMAL TOXICITY (rat LD50): > 2,000 mg/kg
INHALATION TOXICITY (rat LC50): > 5.3 mg/L (4-hour)
EYE IRRITATION: Slightly irritating
SKIN IRRITATION: None to slightly irritating
SKIN SENSITIZATION: Not a contact sensitizer
CARCINOGENICITY: EPA: Not Listed ACGIH: Not Listed NTP: Not Listed IARC: Not Listed OSHA: Not Listed
MUTAGENIC TOXICITY: Metsulfuron-methyl produced genetic damage in a mammalian cell culture test. However, other tests in animals and in bacterial and mammalian cell cultures did not produce genetic damage. Therefore, the weight of the evidence suggests that metsulfuron-methyl does not cause genetic damage.
REPRODUCTIVE TOXICITY: No evidence in animal studies.
http://www.rrsi.com/...DF-SDS-v1.0.pdf
https://www.fda.gov/...y/ucm269126.pdf
Human clinical intervention studies indicate that consumption of OptiMSM' at doses up to 6000 mg/day for twelve weeks was well tolerated, with no clinically significant toxicity reported. The incidences of adverse gastrointestinal and other side effects with MSM administration were comparable to placebo controls.
Edited by Oakman, 17 April 2017 - 12:34 PM.
Posted 19 April 2017 - 11:56 PM
I have noticed some effects on mood when taking ~1-3 grams of MSM. I'm not sure exactly how to describe it except it is vaguely stimulating, gives a certain clarity at times.
Anyway only reason I use it currently is as a solvent for various other supplements, and I have this 1kg bottle, I might as well use some since it seems harmless.
Edited by Keizo, 19 April 2017 - 11:58 PM.
Posted 26 April 2017 - 08:37 PM
I have now tried the combo of msm, glucosamine and chondroitin. I can clearly feel the msm or so I think, it's the increased heart rate when rising and moving. I do think I feel more clear-headed and "aware"? But it's very subtle. I will try megadosing it. Glucosamine is a weird supplement with odd effects at high dosages.
Posted 26 April 2017 - 10:12 PM
I've been taking ~4g MSM, 6g Type 1 & 3 Collagen, 2g Type 2 Collagen, 1.5g Glucosamine and .5g chondroitin, plus 300mg Hyaluronic Acid for three weeks now.... And I feel great... but no better or no worse than I did before taking it. However, I am seeing some marked decrease in facial lines, crows feet, fuller under-eye area, plus overall complexion, which, not surprisingly, is the reason I started taking it in the first place.
Posted 26 April 2017 - 11:26 PM
I've been taking ~4g MSM, 6g Type 1 & 3 Collagen, 2g Type 2 Collagen, 1.5g Glucosamine and .5g chondroitin, plus 300mg Hyaluronic Acid for three weeks now.... And I feel great... but no better or no worse than I did before taking it. However, I am seeing some marked decrease in facial lines, crows feet, fuller under-eye area, plus overall complexion, which, not surprisingly, is the reason I started taking it in the first place.
Do you have saggy skin? If so, let me know if it goes away. That would be huge.
Posted 27 April 2017 - 02:12 AM
I've been taking ~4g MSM, 6g Type 1 & 3 Collagen, 2g Type 2 Collagen, 1.5g Glucosamine and .5g chondroitin, plus 300mg Hyaluronic Acid for three weeks now.... And I feel great... but no better or no worse than I did before taking it. However, I am seeing some marked decrease in facial lines, crows feet, fuller under-eye area, plus overall complexion, which, not surprisingly, is the reason I started taking it in the first place.
Do you have saggy skin? If so, let me know if it goes away. That would be huge.
No fortunately, I do not. Generally, I'm looking about 10 yrs younger than I should, IMO. However, I want to keep it that way, and so the effort to do just that.
Posted 30 April 2017 - 07:55 AM
Do those Collagen supplements actually work? Any studies?
Personally I take Gotu Kola which is proven to increase collagen synthesis:
https://scholar.goog...WLpCDoQgQMIIjAA
Posted 30 April 2017 - 08:24 AM
Posted 30 April 2017 - 12:42 PM
Currently still taking MSM it seems to be doing something which is more than I can say for most supplements I've tried. Not sure if it's good or bad but causes tinnitus changes it lessens it I've spent some time without it though I did eat sugar last night and now tinnitus has returned. What I'm really looking for is something that would allow me to eat whatever I like without getting worse, a miracle I suppose. I have seen 2 different reports on MSM the 1St makes it sound like what Im looking for. The 2nd called it a suppressant that one has to keep taking it and if one ever stops the symptoms comes back much stronger. I thought in what way is that different from a pharmaceutical? People take drugs for the rest of their lives but manage to keep the symptoms at bay. It's advocates say it takes 12 hours to leave the body. It's detractors say the sulphur builds up and is hard to remove. Who should I believe? I am still taking MSM. Guess I have to wait to see if I am doing the right thing. Can anyone here help?
If you want to see the evidence, best to read this GRAS for OptiMSM, the commonly sold MSM product here. It should set your mind at ease re: MSM safety.
Posted 30 April 2017 - 12:59 PM
Do those Collagen supplements actually work? Any studies?
Personally I take Gotu Kola which is proven to increase collagen synthesis:
Well, pls search and you will find them, but from my own searching, yes, somewhat, they do 'work'. From what I have seen, Type II Collagen is the most effective for joints, etc., whereas there is also some effect from Types 1 & 3 for skin over time. Obviously, if any of this this was a cure all for the outward signs of aging, we'd see a whole lot of youngish looking seniors running around... we don't. But for modest improvements, yes, I think it worth the effort for what improvements it does afford.
I take Gotu Kola as well, didn't realize it had collagen effects, so thanks for the heads up, all the better to combine effects for synergy
Posted 30 April 2017 - 02:58 PM
It may be making it difficult for me to sleep
Heart beat currently 79
I'm not sure about it worsening sleep but I do take theanine for sleep quality (theanine should also be good for tinnitus I believe).
The pulse thing for me is weird. It seems to change. There's something about postural hypertension or whatever it's called, when I stand up my heart can race a bit.
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