23 replies to this topic

[Jiminy Glick]

Does anyone know of any good dopamine supplements? 

 

For example would this supplement be good? 

 

https://www.amazon.c...ITV6OtHWYDBd4Xg

[Florian E.]

That depends on what you would like to achieve...

 

- L-Dopa to temporary boost dopamin levels (disadvantage: if often used, body will lower its own dopamine production. L-Tryptophan is safer for longer uses. But also more indirect.)

- (e.g.) Selenium to keep the dopaminergic system healthy

- Many Other D1 receptor agonists or antagonists

- Other substances to increase dopamine receptor density and/or binding sites in the brain

 

But if you just want a temporary dopamine booster to be only used occasionally, L-Dopa is fine for you.

[PeaceAndProsperity]

Chances are you have a superficial understanding of what dopamine does and because of that you want to increase dopamine. p5p is much better for depression than any of that junk herb stuff, and p5p is a vitamin.

Tell us what you want to achieve.

[Jiminy Glick]

Chances are you have a superficial understanding of what dopamine does and because of that you want to increase dopamine. p5p is much better for depression than any of that junk herb stuff, and p5p is a vitamin.

Tell us what you want to achieve.

 

I just want to know how to get dopamine up for motivation and memory. However I am not going to take dopamine pills, I'm just curious.

Edited by Jiminy Glick, 15 April 2017 - 03:13 PM.

[PeaceAndProsperity]

 

Chances are you have a superficial understanding of what dopamine does and because of that you want to increase dopamine. p5p is much better for depression than any of that junk herb stuff, and p5p is a vitamin.

Tell us what you want to achieve.

 

I just want to know how to get dopamine up for motivation and memory. However I am not going to take dopamine pills, I'm just curious.

 

 

Try fasoracetam, it's legal and works on both memory and motivation. With memory it's more glutamate than dopamine. Anyway it's difficult to get any benefits from legal supplements.

[Jiminy Glick]

 

 

Chances are you have a superficial understanding of what dopamine does and because of that you want to increase dopamine. p5p is much better for depression than any of that junk herb stuff, and p5p is a vitamin.

Tell us what you want to achieve.

 

I just want to know how to get dopamine up for motivation and memory. However I am not going to take dopamine pills, I'm just curious.

 

 

Try fasoracetam, it's legal and works on both memory and motivation. With memory it's more glutamate than dopamine. Anyway it's difficult to get any benefits from legal supplements.

 

 

Oh that is interesting. Fasoracetam also works on the GABA receptors, so would Fasoracetam decrease anxiety as well? I would disagree that is difficult to get benefits from legal supplements. Well actually I guess it depends on what your trying to fix. My problem is anxiety, I take take Picamillon, Phenibut (2x a week), Kratom, and just ordered 5-HTP (which I just realized was a mistake) and my anxiety has been so much better. A Kratom and Picamilon mix works great. 

[PeaceAndProsperity]

No, faso tends to increase anxiety at least in myself. Maybe what I bought is not the real deal but who knows. Faso + theanine might be a good blend for reducing anxiety while increase motivation etc.

[Jiminy Glick]

No, faso tends to increase anxiety at least in myself. Maybe what I bought is not the real deal but who knows. Faso + theanine might be a good blend for reducing anxiety while increase motivation etc.

 

Oh okay. I should of bought suntheanine instead of 5-HTP. Isn't that correct? 

[PeaceAndProsperity]

No I don't think so. But try to read up on the mechanism of action instead of the proposed benefits as you will often find out that the proposed benefits just can't be true because the proposed mechanisms don't make sense (e.g. increasing serotonin to reduce depression and anxiety = total nonsense, opposite is likely to be true). Sometimes the benefits are true but not the proposed mechanisms. Or just read the reviews and pay attention to negative reviews the most.

[Jiminy Glick]

No I don't think so. But try to read up on the mechanism of action instead of the proposed benefits as you will often find out that the proposed benefits just can't be true because the proposed mechanisms don't make sense (e.g. increasing serotonin to reduce depression and anxiety = total nonsense, opposite is likely to be true). Sometimes the benefits are true but not the proposed mechanisms. Or just read the reviews and pay attention to negative reviews the most.

 

Wait what? So you think I should be taking 5-HTP for anxiety over Suntheanine? Also 5-HTP is going to reduce my dopamine.

Edited by Jiminy Glick, 15 April 2017 - 05:48 PM.

[PeaceAndProsperity]

By suntheine you mean a patented version of l-theanine that is more "pure" or something? Yes, go for l-theanine. 5htp is dangerous junk. 

But know that theanine is not something people like to take on its own, it decreases noradrenaline and can give some irritating brain fog effects at higher doses, plus drowsiness and whatnot. If you have any schizo-annything disease you will find it to be a good supplement.

But add l-theanine to fasoracetam or something else and you might find it to be a good combination.

 

For social cognition lemon balm has dual action on oxytocin (very mild) and gaba, which is anxiolytic and also improves verbal fluency and bla bla bla.

[Jiminy Glick]

By suntheine you mean a patented version of l-theanine that is more "pure" or something? Yes, go for l-theanine. 5htp is dangerous junk. 

But know that theanine is not something people like to take on its own, it decreases noradrenaline and can give some irritating brain fog effects at higher doses, plus drowsiness and whatnot. If you have any schizo-annything disease you will find it to be a good supplement.

But add l-theanine to fasoracetam or something else and you might find it to be a good combination.

 

For social cognition lemon balm has dual action on oxytocin (very mild) and gaba, which is anxiolytic and also improves verbal fluency and bla bla bla.

 

Interesting, I'll check out lemon balm. Also I wouldn't call 5-HTP dangerous junk, 5-HTP is naturally in your body, it is the precursor to serotonin, but I agree with you it is problematic if is decreases dopamine in supplementation. This is because AAAD is used I think to create serotonin and gaba and AAAD is limited and thus the AAAD is used up. I was wondering if the same goes for dopamine supplement and if this just needs to be a balance. Needless to say I don't think I know how it works. But I know L-Theanine boosts serotonin, dopamine, and gaba so that must be better than 5-HTP.

Edited by Jiminy Glick, 15 April 2017 - 06:30 PM.

[PeaceAndProsperity]

It doesn't matter if what you're taking is part of some metabolic pathway or serves a function in the body. Both l-dopa and 5htp are potentially neurotoxic. Lots of things are potentially toxic if taken in the pure form, including kynurenic acid, nitric oxide, etc.

 

As for l-theanine, see my threads on that subject. Theanine does not in of itself do anything to monoamine neurotransmitters, it works via glutamate instead. Sometimes glutamate receptors increase serotonin receptor activity and sometimes they do the opposite. The same goes for dopamine and all the rest. The relationship is very complex. Additionally there are many subreceptor types that all interact with each other, many parts of the brain where the receptors are expressed and so on.  

I've made a thread on this very subject of theanine and serotonin and I have yet to see why on some days it does the one thing and other days it does the opposite thing.

[Galaxyshock]

Cordyceps - it increases dopamine biosynthesis and is MAOB-inhibitor thus preventing the breakdown of dopamine.

 

But what I don't understand is the obsession with dopamine among neophytes here. Well actually, I do. First time you take a dopaminergic, you get that increased motivation, sense of being alive and feel-good. Then you think hey, this is how I'm supposed to feel and how others must feel - and a self-diagnosis of some sort of "dopamine deficiency" occurs. Dopamine is excellent at "convincing" because it increases wanting and is associated with addiction. From there on it's all about dopamine as if it's some sort of answer to everything. Then you start to become anxious from the DAergic stimulants you take and pop a benzo, and hey now I'm finally calm - I must have GABA deficiency too. It's endless cycle.

Edited by Galaxyshock, 16 April 2017 - 09:30 AM.

[Baten]

I took various Cordyceps sources and never felt any 'dopamine'-like effect though. Not dissing it as a whole, but no motivational, pro-sexual etc. effects whatsoever, for me.

[PeaceAndProsperity]

dopamine stimulants can cause dysphoria and various other paradoxical experiences, keep that in mind

[Galaxyshock]

I took various Cordyceps sources and never felt any 'dopamine'-like effect though. Not dissing it as a whole, but no motivational, pro-sexual etc. effects whatsoever, for me.

 

Only Cordy source that seems to really work for me is Doctor's best Ultra Cordyceps. At one capsule it's subtle, but three caps with a big mug of coffee sends me euphoric and to beast mode at gym. Motivation is strong and I'm virile as hell. But it's different feel than Mucuna though, which is probably dopaminergic in its purest form since L-dopa is direct precursor. With Mucuna the problem for me is any chronic usage starts to make me feel like being poisoned and fever-like effects.

 

 

dopamine stimulants can cause dysphoria and various other paradoxical experiences, keep that in mind

 

 

True, it's the opioid system that "decides" whether you experience euphoria (mu-opioid) or dysphoria (kappa-opioid).

[Baten]

At one capsule it's subtle, but three caps with a big mug of coffee sends me euphoric and to beast mode at gym. Motivation is strong and I'm virile as hell.

 

Hm, interesting. Gotta try this some time.

[fntms]

Cordyceps is indeed great for this, but it's also a strong platelet inhibitor ie a blood thinner (less known effect), I can't take it for more than a few days usually.

[normalizing]

isnt that popular CILTEP stack good for it? i read good reviews on it but i havent tried yet

[Kevnzworld]

The main issue with dopamine, is enzymatic actions that degrade dopamine along with lower production with age.
Deprenyl maintains natural dopamine levels. I buy mine overseas. Life Extension foundation makes an herbal equivalent.
http://www.lifeexten...ng-Drug/Page-01

[Keizo]

Well besides methylphenidate and amphetamine I would say  1. Selegiline. 2. Fulvic Acid ( there's a product called WuJinSan or Pureandfulvic you can check out)

 

L-dopa is probably not very good for you. Tyrosine is also garbage.

Edited by Keizo, 19 April 2017 - 04:34 PM.

[Keizo]

 

 

Chances are you have a superficial understanding of what dopamine does and because of that you want to increase dopamine. p5p is much better for depression than any of that junk herb stuff, and p5p is a vitamin.

Tell us what you want to achieve.

 

I just want to know how to get dopamine up for motivation and memory. However I am not going to take dopamine pills, I'm just curious.

 

 

Try fasoracetam, it's legal and works on both memory and motivation. With memory it's more glutamate than dopamine. Anyway it's difficult to get any benefits from legal supplements.

 

Fasoracetam is the only racetam I have gotten any benefit from, however  who knows what the possible side-effects from some of these newer chems are. At least the common prescription stims have been around for around 100 years.

 

Even with prescription sitmulants the effects are often nowhere near amazing. As mentioned they can cause dysphoria at times (so is my experience with, tyrosine, selegeline,etc), and some other mild problems, in low doses. But the benefit I have experienced from methylphenidate is that difficult things I have started become much more easy to continue doing, and it is easier for me to switch from task to task, meanwhile I am simply more aware of what I am doing with my time. However I don't get motivated to simply start doing things, not at all, unless I have taken a very long break from the drug.

If I were to judge methylphenidate and amphetamine based on a lot of popular opinion and experiences I have read I would think these are the most over-rated shit-drugs ever invented, but on the other hand most of the nootropics that arent prescription are completely useless for me.

Edited by Keizo, 19 April 2017 - 04:50 PM.

[LOOKINGFORTIME]

I thought you may find this interesting, I trust Durk's products(ability to uplift the Dopaminergic Reward System by inhibiting COMT (catechol-O-methyl­transferase). COMT is an enzyme that degrades catecholamines (including dopamine and adrenaline/noradrenaline). When not degraded, catecholamines can be powerful elements for enhanced human behavior and, indeed, the pursuit of happiness.)

http://www.life-enha...greater-rewards

 

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Durk & Sandy designed their formulation containing EGCG (and several other important co-factors) specifically for the purpose of promoting greater rewards and a rewarding life. Other ingredients in Greater Rewards:

• Taurine, an amino acid that increases dopamine levels in the dopamine reward system.

• Vitamin C has been found to help maintain catechin content, so it too was added to Greater Rewards to help protect the bioavailability of EGCG

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