4 replies to this topic

[zaunfink]

Hello,

 

I'm still relatively new to nootropics except for taking 5-HTP at a high dosage to manage my depression for at least two years now.

 

Basically, 3 x 200mg a day took me from "I can't get out of bed" to "Whee, these socks let me slide on the hardwood floor, that's amazing". Basically, I got back to being able to appreciate the world, made me less anxious and all.

Now, with me going back to school and having to interact with people all the time, my dose ranges somewhere between 3 and 5 tablets a day. 3 tablets are not enough in stressfull times to keep me from really struggling.

 

And yet, it never really was enough to get me fully out of the depression - it cycles, for me. There are times when even 5 tablets only manage to get me barely functional, where I need to take a sick day to just recharge and it annoys me horribly. 

 

I'm thinking of trading the high dose of 5-HTP in for a low dose of tianeptine sulfate (25 - 50 mg a day). I'm aware there's a certain possibility for addiction with tia, but I believe myself to not be susceptible enough to be in danger. I've been addicted before and when it got to the level where my health was in real danger, I quit. Never happened since then.

 

 

What I'm not able to properly figure out is how it would interact with the rest of my stack which I mostly take for school(and, admittedly, if it is even all that good). 

I'm currently taking:

 

Rhodiola Rosea to help with falling asleep (which works like a charm) at 300mg

5-HTP to manage my mood at 600-100mg

 

For school:

Huperzine A at 200mcg (experimental, probably gonna use it up and then not rebuy)

Noopept as a nose spray at around 30mg per day (Oh, how I love it.)

Alcar at somewhere between 500mg - 1,5g, depending on the day

Alpha-GPC at 300-600mg a day

DMAE at 50-100 mg (just started, so far not really noticing anything, though 200mg make me sleepy)

 

 

 

Can I safely add tianeptine to this? I thought I might take the tia and drop the 5-HTP at the same time to be able to properly tell how the tia influences me.

 

And: Is there anything I can take for motivation? I'm having a hard time starting tasks, even when I know they'll make me feel better or that there will be consequences if I don't do them.

 

Thank you!

zaunfink

[hdl_1]

Administration of 5-HTP alone depletes catecholamines (dopamine, norepinephrine, and epinephrine). When dopamine depletion is great enough, 5-HTP will no longer function.If other centrally acting monoamine-related disease processes involving catecholamines are present, administration of 5-HTP alone may deplete dopamine, norepinephrine and epinephrine thereby exacerbating these conditions.

To achieve optimal efficacy, minimal side effects, and prevent depletion of other amino acids and neurotransmitters, 5-HTP must be administered in proper balance with dopamine amino acid precursors along with proper levels of sulfur amino acids.

https://www.ncbi.nlm...62/#!po=25.0000


Note: The article above seems to be a bit anti supplements. Just skip through that part. Afterall, if it works for you, no article can tell you otherwise (pacebo or not).
Just add the right dopamine precursors (L phenilalanine/l-tyrosine) and some sulfur amino acids such as NAC and see how you improve. You may have to reduce the 5htp (or l tryptophan) dosage when adding the other precursors to balance the conversion.




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Edited by hdl_1, 29 April 2017 - 01:06 PM.

[jack black]

There is a concern long term 5htp use can damage heart. Some people advise taking it with green tea extract only to limit peripheral conversion to 5ht.

If one is sensitive to 5htp, would that mean good response to SSRI?

[zaunfink]

Thanks for the responses,

 

I've forgotten to add the l-tyrosine because I'm currently out of it, but I've been taking them together (on and off, if I'm honest. I've never noticed a difference. I seem to even remember that article. 

 

But, that's why I'm trying to get rid of the htp. I know I can't handle life and school and everything without it or perhaps more correctly - I don't want to.

[hdl_1]

Thanks for the responses,

I've forgotten to add the l-tyrosine because I'm currently out of it, but I've been taking them together (on and off, if I'm honest. I've never noticed a difference. I seem to even remember that article.

But, that's why I'm trying to get rid of the htp. I know I can't handle life and school and everything without it or perhaps more correctly - I don't want to.

Look into Agmatine if you choose to pursue glutamate modulation substances such as Tianeptine. It's a natural version for NMDA inhibitory modulation.

https://www.ncbi.nlm...pubmed/27061850


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