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Melatonin causes borderline and schizotypal symptoms upon waking

melatonin borderline personality disorder schizotypal

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#1 PeaceAndProsperity

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Posted 07 May 2017 - 11:57 PM


I didn't usually have these experiences when taking melatonin until recently when I tried a new brand that has been lying around for a while. With this brand it's almost everytime I use it even in extremely low amounts (below 200mcg) that I have these reactions but practically only when I wake up and not the night before when I actually take it.

I will tend to wake up with real paranoia or very strong emotions as seen in borderline pd.

Several of my emotions are greatly enhanced and my perception is altered to the point of feeling hurt by everyone and extreme hatred. Not only this but the melatonin can also worsen sleep quality considerably which very strongly occurs together with the paranoia and emotional side-effects.

I suspect this has to do with the 5HT2A receptor, but doesn't everything?

 

I don't have any characteristic symptoms of borderline personality disorder and paranoia has never been an issue of mine.

 

It turns out that one of the recognized side-effects of melatonin is indeed paranoia. I just wanted to share my own experience, especially in relation to borderline personality disorder.



#2 Mind_Paralysis

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Posted 09 May 2017 - 09:21 AM

It may be that your experience is not necessarily in relation to Borderline "PD"[1] but to potential Affective dysfunction, i.e BIPOLAR - perhaps you are not merely on the Schizoid spectrum, but on the Bipolar one as well?

 

Most of the reports I've seen regarding affective dysfunction from Melatonin is in regards to Bipolar Disorder - where in some sensitive individuals, it can induce mild switching - and in patients stricken with Rapid Cycling in particular, it can induce VERY clear switches! It should be noted, that circadian abnormalities have been implicated in the mechanisms underlying Bipolar - this is why there is a growing push to include SAD - Seasonal Affective Disorder as a form of Bipolar.

 

 

Schizoaffective Disorder is a real thing, and genetic studies have found that Schizophrenia and Bipolar are the two disorders whom have the most genes in common.

 

(interestingly enough, the same genetic studies also found that AUTISM and Schizophrenia are the two diseases which have the LEAST genes in common! if one takes into consideration that two of the newer theories regarding the basic underlying mechanisms behind both involve increased and decreased synaptic growth respectively, then this does make some sense)

 

 

References:

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[1] As previously discussed, I, and many experts, do no longer consider Borderline to be a PD - newer data supports the idea that it's a Neurodevelopmental Disorder, similar in some ways to ADHD and/or Autism.

 

 



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#3 PeaceAndProsperity

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Posted 09 May 2017 - 09:40 AM

I would say it fits borderline very well when you look at the characteristic perception of being hurt by people, the feeling of abandonment and several other things.

 

Very interestingly, l-theanine seems to help the paranoia somewhat but not the borderline perception (at least in the dosages I've been taking it). There's interesting relationships between glutamate and serotonin. You'd think the nmda receptor would sensitize the serotonin receptors but doesn't appear to be quite so. Maybe it's the same receptor causing the paranoia and distorted borderline perception but in different areas of the brain? Still you'd expect l-theanine to work on both things if it worked on one.







Also tagged with one or more of these keywords: melatonin, borderline personality disorder, schizotypal

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