• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Resistant Starch increases TMAO

resistant starch tmao

  • Please log in to reply
3 replies to this topic

#1 ta5

  • Guest
  • 952 posts
  • 324
  • Location: 

Posted 14 May 2017 - 03:38 PM


Br J Nutr. 2016 Dec;116(12):2020-2029. 

Bergeron N1, Williams PT2, Lamendella R3, Faghihnia N1, Grube A3, Li X4, Wang Z4, Knight R5, Jansson JK6, Hazen SL4, Krauss RM1.
Production of trimethylamine-N-oxide (TMAO), a biomarker of CVD risk, is dependent on intestinal microbiota, but little is known of dietary conditions promoting changes in gut microbial communities. Resistant starches (RS) alter the human microbiota. We sought to determine whether diets varying in RS and carbohydrate (CHO) content affect plasma TMAO levels. We also assessed postprandial glucose and insulin responses and plasma lipid changes to diets high and low in RS. In a cross-over trial, fifty-two men and women consumed a 2-week baseline diet (41 percentage of energy (%E) CHO, 40 % fat, 19 % protein), followed by 2-week high- and low-RS diets separated by 2-week washouts. RS diets were assigned at random within the context of higher (51-53 %E) v. lower CHO (39-40 %E) intake. Measurements were obtained in the fasting state and, for glucose and insulin, during a meal test matching the composition of the assigned diet. With lower CHO intake, plasma TMAO, carnitine, betaine and γ-butyrobetaine concentrations were higher after the high- v. low-RS diet (P<0·01 each). These metabolites were not differentially affected by high v. low RS when CHO intake was high. Although the high-RS meal reduced postprandial insulin and glucose responses when CHO intake was low (P<0·01 each), RS did not affect fasting lipids, lipoproteins, glucose or insulin irrespective of dietary CHO content. In conclusion, a lower-CHO diet high in RS was associated with higher plasma TMAO levels. These findings, together with the absence of change in fasting lipids, suggest that short-term high-RS diets do not improve markers of cardiometabolic health.
PMID: 27993177 

  • Informative x 3

#2 ketogeniclongevity

  • Guest
  • 23 posts
  • -1
  • Location:usa

Posted 15 May 2017 - 06:03 AM

Carbohydrates are not good for the body. Period. Humans aren't designed to eat as many carbohydrates as they eat today. Traditional diets were primarily composed of health-maximizing fats like those found in bison. Yams and potatoes were only foraged for once every few months. Our ancestors did not indulge in carbohydrates because they had less carbohydrates than they do today. Treat carbs as a rare, rare treat or you'll develop cardiac deficiencies.

30D1286D00000578-3428689-image-a-19_1454

Bananas of the past had about 30 calories, mostly of protein and fat(from seeds). Now they are about 150 calories of carbohydrates. They were hybridized to have more catastrophic carbs that have caused the majority of the diseases in modern society. It's the same for other carbohydrates. Potatoes, fruits, etc... never had as many carbs as they do now. They mostly stored plant protein, which is inferior to animal protein.


Edited by ketogeniclongevity, 15 May 2017 - 06:09 AM.

  • Ill informed x 2
  • Disagree x 1

sponsored ad

  • Advert
Click HERE to rent this advertising spot for NUTRITION to support LongeCity (this will replace the google ad above).

#3 tunt01

  • Guest
  • 2,308 posts
  • 414
  • Location:NW

Posted 15 May 2017 - 02:13 PM

I'm not sure what to make of this whole TMAO issue.  I'm kind of in the Mark McCarty camp and taking a wait and see attitude, while avoiding eggs, red meat, and large amounts of dietary choline/supplements.  

 

I think TMAO may ultimately only be a coincident biomarker.  Alternatively, resveratrol/allicin and other compounds have been shown to inhibit TMAO formation.

 

If anyone can get the supplement downloaded, I'd like to see it related to this section:

 

Notably, we observed that, independent of starch digestibility, higher-CHO
diets increased plasma TAG and large VLDL particle concentrations, and promoted a shift in LDL particle distribution towards
more medium and small LDL (Supplementary Fig. S4), in
keeping with the recognised effect of carbohydrates on features
of atherogenic dyslipidemia
(4751), and in overall agreement with
the recent OmniCarb study
(52), which found that plasma TAG
were increased by higher CHO intake, but were not in
fluenced
by starch quality as assessed by the glycaemic index

 

 

 

Seems strange to me given that Table 5 shows higher mass for sd-LDL on the low-CHO diet, with p-value 0.06.  I guess the particle counts were worse under higher CHO, but the mass was greater under low-CHO ?  I don't get it.

 

EDIT:

 

Seems like the low-CHO arm started out with significantly higher sd-LDL, LDL levels by comparison.

 

0TkT7Q8.png

 

 


Edited by prophets, 15 May 2017 - 02:25 PM.

  • Informative x 2

#4 aza

  • Guest
  • 128 posts
  • 27
  • Location:aus
  • NO

Posted 15 August 2018 - 01:10 PM

This is interesting https://www.ncbi.nlm...pubmed/28091798

Intake of up to 3 Eggs/Day Increases HDL Cholesterol and Plasma Choline While Plasma Trimethylamine-N-oxide is Unchanged in a Healthy Population.

"With intake of 2-3 eggs/day, these changes were maintained. Plasma choline increased dose-dependently with egg intake (P < 0.0001) while fasting plasma TMAO was unchanged. These results indicate that in a healthy population, consuming up to 3 eggs/day results in an overall beneficial effect on biomarkers associated with CVD risk, as documented by increased HDL-c, a reduced LDL-c/HDL-c ratio, and increased plasma choline in combination with no change in plasma LDL-c or TMAO concentrations."


  • Informative x 1





Also tagged with one or more of these keywords: resistant starch, tmao

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users