5 replies to this topic

[WaterNoot]

Hi,

 

I'm looking for a good NDRI antidepressant.

Requirements: Improved cognitive function, no neurotoxicity.

 

I thought about Prolintane, what do you think about it?

 

Other interesting options:

Nomifensine

Methylenedioxypyrovalerone

Pipradrol

Pyrovalerone

Fencamfamin

Dexmethylphenidate

 

Do you know others?

 

Thanks in advance.

Regards.

Edited by WaterNoot, 15 May 2017 - 05:15 PM.

[Mind_Paralysis]

Dexmethylphenidate?? seriously dude! you ARE aware that MPH (although racemic) is known to cause severe anxiety and depression?? it's failed in every bigger trial for the treatment of depression - just like amphetamine. I'd remove it from the list ASAP if I were you.

 

Anyways, it sounds like you should give SELEGILINE a try - it fits your criteria fairly well.

 

https://en.wikipedia...wiki/Selegiline

 

 

There's also a banned drug called Amineptine, which works as a DNRI, among other things - it's closely related to TIAneptine, which is a rather famous AD you've probably heard of.

 

https://en.wikipedia...wiki/Amineptine

 

It should be able to give you what you need.

[Finn]

http://www.longecity...d-by-modafinil/

 

Considering your reaction to a relatively "weaksauce" dopaminergic/noradrenergic agent, some of these medications could be quite risky also.

[WaterNoot]

Dexmethylphenidate?? seriously dude! you ARE aware that MPH (although racemic) is known to cause severe anxiety and depression?? it's failed in every bigger trial for the treatment of depression - just like amphetamine. I'd remove it from the list ASAP if I were you.

 

Anyways, it sounds like you should give SELEGILINE a try - it fits your criteria fairly well.

 

https://en.wikipedia...wiki/Selegiline

 

 

There's also a banned drug called Amineptine, which works as a DNRI, among other things - it's closely related to TIAneptine, which is a rather famous AD you've probably heard of.

 

https://en.wikipedia...wiki/Amineptine

 

It should be able to give you what you need.

 

I'm currently taking Methylphenidate for ADHD. It is without doubt the substance that contrasts better my chronic depression. The psychiatrist/s agrees on this point. Many trustworthy internet sources report it as a valid therapy for SSRI-resistant depression. Paradoxically, I'm probably an exception, it also makes me less anxious and obsessive. It's really useful, but I would like to combine another antidepressant to maximize the treatment. 

 

I'm sure my depression comes from a dopaminergic, non-serotoninergic, imbalance.

I tried 2 months of therapy with IMAO-A/B [Moclobemide + Selegiline], without any beneficial effect, even at least.

I tried 2 months of Vortioxetine therapy, no minimum benefit.

I tried 2 months of Lithium, extended release, no minimum benefit.

 

At the time I assume:

Omega 3: As Mood Stabilizer [Depressive Phases]

Methylphenidate: ADHD and antidepressant

Selegiline: Antidepressant and potentiator of Methylphenidate effects.

 

I'm also going to combine Fasoracetam, anxiolytic/pro ADHD

 

---------------------------------------------------------------------------------------------

 

What I miss is a good antidepressant NDRI.

Your proposal looks very good, I will search informations.

Thanks so much.

Of the other proposals what do you think?

 

 

http://www.longecity...d-by-modafinil/

 

Considering your reaction to a relatively "weaksauce" dopaminergic/noradrenergic agent, some of these medications could be quite risky also.

 

I've never had problems with normal doses, in either case.

Modafinil/Armodafinil, individually, even at medium to high dosages, have never invalidated me in the long run.

Dosages too high, or the combination with Ritalin, are the reason for the problem.

Ritalin, individually, is extremely useful, changing my life.

My depression is caused by a dopaminergic imbalance.

[Mind_Paralysis]

 

Dexmethylphenidate?? seriously dude! you ARE aware that MPH (although racemic) is known to cause severe anxiety and depression?? it's failed in every bigger trial for the treatment of depression - just like amphetamine. I'd remove it from the list ASAP if I were you.

 

Anyways, it sounds like you should give SELEGILINE a try - it fits your criteria fairly well.

 

https://en.wikipedia...wiki/Selegiline

 

 

There's also a banned drug called Amineptine, which works as a DNRI, among other things - it's closely related to TIAneptine, which is a rather famous AD you've probably heard of.

 

https://en.wikipedia...wiki/Amineptine

 

It should be able to give you what you need.

 

I'm currently taking Methylphenidate for ADHD. It is without doubt the substance that contrasts better my chronic depression. The psychiatrist/s agrees on this point. Many trustworthy internet sources report it as a valid therapy for SSRI-resistant depression. Paradoxically, I'm probably an exception, it also makes me less anxious and obsessive. It's really useful, but I would like to combine another antidepressant to maximize the treatment. 

 

I'm sure my depression comes from a dopaminergic, non-serotoninergic, imbalance.

I tried 2 months of therapy with IMAO-A/B [Moclobemide + Selegiline], without any beneficial effect, even at least.

I tried 2 months of Vortioxetine therapy, no minimum benefit.

I tried 2 months of Lithium, extended release, no minimum benefit.

 

At the time I assume:

Omega 3: As Mood Stabilizer [Depressive Phases]

Methylphenidate: ADHD and antidepressant

Selegiline: Antidepressant and potentiator of Methylphenidate effects.

 

I'm also going to combine Fasoracetam, anxiolytic/pro ADHD

 

---------------------------------------------------------------------------------------------

 

What I miss is a good antidepressant NDRI.

Your proposal looks very good, I will search informations.

Thanks so much.

Of the other proposals what do you think?

 

 

http://www.longecity...d-by-modafinil/

 

Considering your reaction to a relatively "weaksauce" dopaminergic/noradrenergic agent, some of these medications could be quite risky also.

 

I've never had problems with normal doses, in either case.

Modafinil/Armodafinil, individually, even at medium to high dosages, have never invalidated me in the long run.

Dosages too high, or the combination with Ritalin, are the reason for the problem.

Ritalin, individually, is extremely useful, changing my life.

My depression is caused by a dopaminergic imbalance.

 

 

You should have told us you had ADHD as well though, dude... patients with ADHD typically have an atypical response to stimulants. I would definitively agree that stimulants help with ADHD-depression, since in those cases, the depression is actually a RESULT of living a life hampered by ADHD-symptoms - removing the symptoms then gives the mind and the brain the chance it needs to recuperate.

 

Tranylcypromine (parnate, et c), another MAOI, which is selective for MAO-B - aka Dopamine, could be easier to get prescribed than Selegiline btw - it's generally considered to be the more activating of the old MAOI's - it also actually has a small effect as a releasing-agent of dopamine and norepinephrine, similar to Amphetamines mechanism of action - this action is 10 times weaker though.

 

 

Still, there's something I find curious, namely that you mention that your depression isn't constant? You mention how it comes and goes, in phases? That sounds suspiciously like Bipolar, dude... I actually met a woman recently, a life-time hyperactive former alcoholic, who was erroneously diagnosed with ADHD, when as a matter of fact, she was in reality a Bipolar with a more unusual manifestation - she was almost always MANIC instead of depressed - stimulants then smashed her up pretty badly - the Dr.'s attempted treatment for more than a year before they put her on a COCKTAIL - that's right, COCKTAIL of mood-stabilisers.

 

Have you really been evaluated for Bipolar? You could also have some kind of Bipolar NOS - Not Otherwise Specified - a rare, unusual representation which doesn't fit the normal criteria.
 

[Boopy!]

I have really bad ADHD and depression and lately feel like the Ritalin I take eventually peters out once my body adjusts and then I'm back to baseline,   homeostasis and all that.   But some might get the constant help from it.   I was on Pristique years ago and loved it but it was overpriced at the time.   Now it wouldn't be but I am hesitant to get back on it because for me the up and down were awful with another NDRI I took,   Effexor.     I later found out it was because it has a short half life;  if you skip it or miss a dose as I often do  (being an ADD type and disorganized),  it is hell.   Of course I was never TOLD this by my shrink;  so if you do take anything make sure to take it  correctly.   Some even half the dosage -- half in morning and half eight hours or so later.   I swig pills in a shot glass as I leave in the morn,  so no way would I take the time to be all precise.

 

Effexor is prescribed where I am to so many people;  I know this because I do taxes for a lot of people and see this in their receipts from the pharm.  all the time.   The other one is Lorazepam.   EVERYONE seems to be on these.   But the way I see it is:   it's a crap shoot and there is NO way to say point blank something is the "best"  for everyone.   What works for you won't work for someone else and my shrink admitted to me that it's all random.   They throw it at you depending on how you appear to them,   and see if it works.   No one should be telling you what is the "best"  NDRI without knowing you,  what you are like,   how you function down to a tee.

 

I wish to God I could get a high from a stimulant but I suppose I am the kind of ADHD that just gets more "normal"  or focused,   not a stimulus.     Also I have read that stimulant type meds AND Prozac can permanently change brain chemistry into being far more bipolar  (or rather,  that many people originally taking these end up being prescribed meds for bipolar,   for various reasons.)   My theory is that either they were misdiagnosed to begin with,  that meds are prescribed in "trends,"  which is true,  or that their brain adjusts and transforms  (which it does anyway,  with age and lifestyle.)   Also I have known quite a few Bipolar NOS,   and only know a few Bipolar I.   Half the people in drug recovery are Bipolar NOS.