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Retrotope and collaborators to present poster at the 2017 American Academy of Neurosciences Meeting in Boston on stabili

isotope-reinforced polyunsaturated lipids (d-pufas) retrotope alzheimer’s disease mouse models mikhail s. shchepinov ph.d

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#1 alc

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Posted 20 May 2017 - 02:21 PM


https://www.retrotope.com/news/

https://www.retrotope.com/

http://www.neurology...nt/P4.090.short

"

Results: In the 3xTgAD mouse model, toxic beta amyloids and ratios indicative of
disease are lowered statistically in the hippocampus, and brain lipid peroxidation
markers (neuro- and iso-prostanes) are dramatically lowered. In the Aldh2−/− model,
multiple cognitive function tests demonstrate reversal of cognitive impairment
in Aldh2−/− mice fed the D-PUFA diet to a level of cognitive performance similar
to WT mice, whereas no such changes occurred in Aldh2−/− mice fed the control diet.

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