Alas, this is an old thread, but I'm going to post in it anyway.
This isn't a journal article, but I found it very interesting.
I got interested in RNA because I am a fast metabolizer according to Rudolph Wiley in his book BioBalance. He says that fast metabolizers NEED purines from foods such as organ meats and sardines in order to STAY alkalized. Yeah, you read that right. His is a very unusual take on the acid-alkaline debate, which I would probably ignore, except that it totally works for me. Wiley explains why in his book. So, only about 12% of the population are fast metabolizers, they really need purines... but how much organ meat and sardines can a person EAT? Enter Dr. Dean's article and Dr. Frank's (old!) book, The No Aging Diet. And RNA pills!
Six weeks later, I am clear that this supplementation has many benefits for me: increased strength and endurance being the main one. Friends are saying I look younger.
Are you one of these fast metabolizers? Wiley gives a ball park test: are you sensitive to caffeine? If you started the day with a cup of coffee and nothing else, how would that day likely go? For fast metabolizers, not well. Another ball parker: how do you do with a water fast? Wanna die by the second day? Probably a fast metabolizer.
So... if you can't do coffee alone (I can do some coffee if I feed it) and if water fasting is just awful, there's a good chance that RNA supplementation might work really well for you.
Slow metabolizers, on the other hand, actually do better avoiding purines (and probably RNA supps), which can increase uric acid and give them gout.