9 replies to this topic

[stefan_001]

https://finance.yaho...-103000454.html


“Our research indicates that normalizing tumor cell metabolism could very efficiently enhance cancer therapy,” said Dr. Felding. “The planned studies may identify a novel way to enhance treatment responses and improve the quality of life for cancer patients.”

[MikeDC]

http://www.scripps.edu/felding/

[MikeDC]

Very convincing evidence

Attached Files

•  image.jpg   24.77KB   2 downloads

[Bryan_S]

Let Sleeping Cancer Cells Lie

http://ww5.komen.org...an_pink6-06.pdf

Santidrian suspected that an imbalance of NAD+ and NADH was responsible for the aggressive behavior in the cancer cells that metastasized. To test this hypothesis, he cleverly transferred a Complex I gene found in yeast to the human breast cancer cells in an attempt boost Complex I activity. He then transplanted the modified cancer cells into mice to see if they would grow and metastasize. He found that the breast cancer cells, which did not have the newly added yeast gene, grew rapidly and metastasized in the mice, while cells that had the working yeast gene did not.

Convinced that the excess NADH was making the tumor cells more aggressive, Santidrian tried a simpler approach. Because NAD+ is made by the cell from vitamin B3, he added a form of vitamin B3 called nicotinamide to the drinking water of the mice. He found that the nicotinamide-supplemented water was able to reduce tumor growth and prevent metastasis, even in the most aggressive breast tumors.

“This is the first study to show a direct relationship between abnormal Complex I and tumor cell aggressiveness,” noted Dr. Felding-Habermann. “It represents the kind of breakthrough discovery we hope to achieve.” 

 

"Complex I is a key component of cellular respiration, the process in which the cell consumes oxygen and produces energy. A major function of Complex I is to generate NAD+, a molecule that is essential for many important processes in a healthy cell. Dr. Santidrian found that the production of NAD+ is disturbed in the aggressive breast cancer cells.

As illustrated here, cellular respiration begins as NADH transfers its energy to Complex I and is converted to NAD+. In healthy cells, there is a balance of NADH and NAD+ levels. In cells with abnormal Complex I function, an excess of NADH accumulates. This causes the tumor cells to panic and activate survival pathways that promote tumor growth."

 

Dr. Antonio F. Santidrian, is a Senior Research Associate in Felding-Habermann’s lab and is worth a read as well.

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

https://www.jci.org/...cles/view/64264

 

Scripps Research Institute Scientists Find Promising New Approach to Preventing Progression of Breast Cancer

https://www.scripps....215felding.html

 

https://www.google.c...6011360A1?cl=en

 

Let's also not forget the ONTRAC study and its contributions.

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

 

Also similar research on liver cancer.

Boosting NAD+ for the prevention and treatment of liver cancer

https://www.ncbi.nlm...les/PMC4905329/

 

Derivative of vitamin B3 prevents liver cancer in mice

https://www.scienced...41120123234.htm

 

Taken together who wouldn't research this!

[Michael]

Very convincing evidence

 

To be clear, the graph and histology slide you attached are from Felding's previous work with plain Jane nicotinamide, not any yet-to-be-conducted NR work.

[MikeDC]

Very convincing evidence

To be clear, the graph and histology slide you attached are from Felding's previous work with plain Jane nicotinamide, not any yet-to-be-conducted NR work.

I know. NR might actually cure the cancer.

[stefan_001]

Aberrant Acetylation of Mitochondrial Proteins, due to Loss of SIRT3, Results in Tumor Permissive Phenotypes and Increases Breast Cancer Malignancy Risk

 

http://search.proque...bl=18750&diss=y

 

 

 

 

 

[Bryan_S]

 

 

Very convincing evidence

To be clear, the graph and histology slide you attached are from Felding's previous work with plain Jane nicotinamide, not any yet-to-be-conducted NR work.

I know. NR might actually cure the cancer.

 

 

More specifically it "might" put the breaks on "some kinds of cancers" in the beginning stages. Let's see where this goes. Here is some of the the previous research at Felding's Lab: http://www.jci.org/articles/view/64264

 

We can see there has been a lot of encouraging research but the oncology research field is split between starving a cell of NAD to enhance cancer treatments by debilitating a cancer cells ability to survive chemotherapy, and enhancing NAD to encourage cellular repair pathways to prevent it in the first place. So these approaches are in opposition and the possible benefits, pathways and strategies are now just beginning to be mapped out.

 

There is also more to this story as Brunhild Felding-Habermann explains:

https://www.scripps....-habermann.html

 

Further reading:

http://www.sandiegou...eb15-story.html

[stefan_001]

NAD+ Deficits in Age-Related Diseases and Cancer

 

Diseases and cancer are inherent parts of the aging process and aging can be considered as a disease among other diseases while we age.

NAD+ levels are described to decrease during aging, likely through changes in metabolic reactions leading to NAD+ synthesis.

Models for age-related diseases and cancer show reductions in NAD+ pools.

Boosting NAD+ through precursors such as NAM, NMN or NR may increase longevity and prevent age-related diseases and cancer in animal models

 

http://www.cell.com/...8033(17)30105-X

[MikeDC]

There is a mouse study that showed liver cancer is initiated when NAD+ is low and increasing NAD+ cured the cancer. They also mentioned this is true for a few other cancers they tested.