19 replies to this topic

[kurdishfella]

yohimbe

white willow bark

L-Dopa

Activated Charcoal

shilajit

L-lysine

L-Histidine

Choline

panax ginseng

Agnus castus 

Feverfew

Berberine

Gingkgo biloba

ginger root

Ziziphus

Jujube

Magnolia

bcaa

tyrosine

phenylalanine

Taurine 

thiamine 

theanine

nicotinic acid

Collagen 

Famotidine

Aspirin 

Benadryl

Resveratrol 

Sodium

[PeaceAndProsperity]

Most of the things you listed increase serotonin.

[kurdishfella]

Most of the things you listed increase serotonin.

fuck off

[iseethelight]

I'm the poster child for someone with excessive serotonin and I've tried most of these on lists. Like you, I saw internet articles and even pubmeds claiming that these supps lower serotonin but they either didn't work or they only worked the brief period (a few hours first couple doses).

 

The issue with using supplements to reduce serotonin is that they only work (if at all) for a short period and then they make you feel worse afterwards. The reason for this is that the half life of most of these is either super short or they require unrealistic (dangerous) dosages to be effective. Also the receptors quickly up-regulate. 

 

I think the best / most effectiveway to reduce serotonin is to limit the intake of dietary tryptophan. Everything else is BS..I've tried them all.

 

Also these supplements have adverse side effects due to their effects on other neurotranmitters and other things. 

Edited by iseethelight, 10 July 2017 - 11:27 PM.

[prunk]

 

Most of the things you listed increase serotonin.

fuck off

 

Definately do not try to decrease your serotonin levels.

 

https://www.ncbi.nlm...les/PMC2612120/

 

http://www.cam.ac.uk...sponse-to-anger

 

https://www.newscien...ain-aggression/

[kurdishfella]

 

 

Most of the things you listed increase serotonin.

fuck off

 

Definately do not try to decrease your serotonin levels.

 

https://www.ncbi.nlm...les/PMC2612120/

 

http://www.cam.ac.uk...sponse-to-anger

 

https://www.newscien...ain-aggression/

 

http://www.medicalne...ases/281645.php

 

http://www.independe...s-a7207421.html

 

http://www.sciencedi...149763415000287

 

https://www.scienced...50217114119.htm

 

http://www.sciencedi...166432800003934

 

http://www.parenther...um-disorder.htm

 

https://www.ncbi.nlm...pubmed/20139991

 

http://www.nature.co...ature05991.html

 

http://io9.gizmodo.c...eory-1686163236

 

http://www.salon.com...ession_partner/

 

http://journals.plos...al.pone.0105941

 

you have no clue you should keep quiet.

Edited by farshad, 11 July 2017 - 10:45 AM.

[ThreeKings12341]

 

 

 

Most of the things you listed increase serotonin.

fuck off

 

Definately do not try to decrease your serotonin levels.

 

https://www.ncbi.nlm...les/PMC2612120/

 

http://www.cam.ac.uk...sponse-to-anger

 

https://www.newscien...ain-aggression/

 

http://www.medicalne...ases/281645.php

 

http://www.independe...s-a7207421.html

 

http://www.sciencedi...149763415000287

 

https://www.scienced...50217114119.htm

 

http://www.sciencedi...166432800003934

 

http://www.parenther...um-disorder.htm

 

https://www.ncbi.nlm...pubmed/20139991

 

http://www.nature.co...ature05991.html

 

http://io9.gizmodo.c...eory-1686163236

 

http://www.salon.com...ession_partner/

 

http://journals.plos...al.pone.0105941

 

you have no clue you should keep quiet.

 

 

u dont need those supps, you def need a treatment for your aggressive behavior, but before you answer in a rude way again . i just want to let u know: I really dont care
 

[jack black]

No one should answer to his threads only to be treated with obscenities. OP needs help for sure, this is why we have mental hospitals.

[kurdishfella]

No one should answer to his threads only to be treated with obscenities. OP needs help for sure, this is why we have mental hospitals.

whatever you say Puss. you just another sheep giving up to group pressure.

[jack black]

Go fuck yourself

[PeaceAndProsperity]

I'm the poster child for someone with excessive serotonin and I've tried most of these on lists. Like you, I saw internet articles and even pubmeds claiming that these supps lower serotonin but they either didn't work or they only worked the brief period (a few hours first couple doses).

 

The issue with using supplements to reduce serotonin is that they only work (if at all) for a short period and then they make you feel worse afterwards. The reason for this is that the half life of most of these is either super short or they require unrealistic (dangerous) dosages to be effective. Also the receptors quickly up-regulate. 

 

I think the best / most effectiveway to reduce serotonin is to limit the intake of dietary tryptophan. Everything else is BS..I've tried them all.

 

Also these supplements have adverse side effects due to their effects on other neurotranmitters and other things. 

Lowering serotonin in one brain part or blocking one out of the how many - 14 receptors, is not the same as lowering serotonin itself.

Almost all the supplements he listed are either serotonin agonists or they increase serotonin levels.

 

What are you talking about that serotonin receptors quickly upregulate? They definitely don't, especially not the 5ht2a receptor which is what expresses hyperserotonemia, irritability, fatigue and various other psychiatric symptoms.

 

Tryptophan is in pretty much every food. Good luck eliminating it from your diet. You also need tryptophan for more than just serotonin production.
 

[iseethelight]

 

I'm the poster child for someone with excessive serotonin and I've tried most of these on lists. Like you, I saw internet articles and even pubmeds claiming that these supps lower serotonin but they either didn't work or they only worked the brief period (a few hours first couple doses).

 

The issue with using supplements to reduce serotonin is that they only work (if at all) for a short period and then they make you feel worse afterwards. The reason for this is that the half life of most of these is either super short or they require unrealistic (dangerous) dosages to be effective. Also the receptors quickly up-regulate. 

 

I think the best / most effectiveway to reduce serotonin is to limit the intake of dietary tryptophan. Everything else is BS..I've tried them all.

 

Also these supplements have adverse side effects due to their effects on other neurotranmitters and other things. 

Lowering serotonin in one brain part or blocking one out of the how many - 14 receptors, is not the same as lowering serotonin itself.

Almost all the supplements he listed are either serotonin agonists or they increase serotonin levels.

 

What are you talking about that serotonin receptors quickly upregulate? They definitely don't, especially not the 5ht2a receptor which is what expresses hyperserotonemia, irritability, fatigue and various other psychiatric symptoms.

 

Tryptophan is in pretty much every food. Good luck eliminating it from your diet. You also need tryptophan for more than just serotonin production.
 

 

Show studies to back up your claims that these increase serotonin . Also you can't eliminate any amino acids completely but you can reduce them. There are many foods low in tryptophan... I said reduce them.

 

By the way, aggression is a sign of high serotonin.

OP is showing sign of that ( i know because i've been there) .

OP,

Look at the supps you're currently taking and look at your diet. 

Some common supplements that increase serotonin synthesis you wouldn't suspect are vitamin d, calcium, EPA/DHA, methyl donors, etc. 

Foods include  whey protein, chick breast, bananas, oatmeat, egg whites, etc.

 

[kurdishfella]

 

 

I'm the poster child for someone with excessive serotonin and I've tried most of these on lists. Like you, I saw internet articles and even pubmeds claiming that these supps lower serotonin but they either didn't work or they only worked the brief period (a few hours first couple doses).

 

The issue with using supplements to reduce serotonin is that they only work (if at all) for a short period and then they make you feel worse afterwards. The reason for this is that the half life of most of these is either super short or they require unrealistic (dangerous) dosages to be effective. Also the receptors quickly up-regulate. 

 

I think the best / most effectiveway to reduce serotonin is to limit the intake of dietary tryptophan. Everything else is BS..I've tried them all.

 

Also these supplements have adverse side effects due to their effects on other neurotranmitters and other things. 

Lowering serotonin in one brain part or blocking one out of the how many - 14 receptors, is not the same as lowering serotonin itself.

Almost all the supplements he listed are either serotonin agonists or they increase serotonin levels.

 

What are you talking about that serotonin receptors quickly upregulate? They definitely don't, especially not the 5ht2a receptor which is what expresses hyperserotonemia, irritability, fatigue and various other psychiatric symptoms.

 

Tryptophan is in pretty much every food. Good luck eliminating it from your diet. You also need tryptophan for more than just serotonin production.
 

 

Show studies to back up your claims that these increase serotonin . Also you can't eliminate any amino acids completely but you can reduce them. There are many foods low in tryptophan... I said reduce them.

 

By the way, aggression is a sign of high serotonin.

OP is showing sign of that ( i know because i've been there) .

OP,

Look at the supps you're currently taking and look at your diet. 

Some common supplements that increase serotonin synthesis you wouldn't suspect are vitamin d, calcium, EPA/DHA, methyl donors, etc. 

Foods include  whey protein, chick breast, bananas, oatmeat, egg whites, etc.

 

eating a low tryptophan would be too difficult for me.

Im now trying to find a solution to make my MAO-A more active as it breaks down serotonin etc.

 

i wanna get to the problem what causes my high serotonin. All I know is my genes make it so  I end up with  more serotonin. I suspect I have something called Brunner syndrome (warrior gene) 

 

''Brunner syndrome is a rare genetic disorder associated with a mutation in the MAOA gene.

Brunner syndrome is caused by a monoamine oxidase A (MAOA) deficiency, which leads to an excess of monoamines in the brain, such as serotonin, dopamine, and norepinephrine(noradrenaline). In both mice and humans, a mutation was located on the eighth exon of the MAO-A gene, which created a dysfunctional MAO-A gene. The regular function of MAO-A, breaking down monoamines, is disrupted, and monoamines build up within the brain. Mice that lacked a functional MAO-A gene displayed higher levels of aggression, in comparison to mice with a functional MAO-A gene

Characteristic biochemical abnormalities included high serum serotonin .

Symptomatic individuals have particularly high serotonin levels, and treatment with a serotonin reuptake inhibitor and dietary modification resulted in reversal of biochemical abnormalities, reduction of 'serotonergic' symptoms and behavioural improvement.''

 

 

Might try something like Apigenin , Luteolin or Valproic Acid

 

https://www.ncbi.nlm...pubmed/19815045

 

https://www.ncbi.nlm...les/PMC3187529/

Edited by farshad, 13 July 2017 - 05:11 PM.

[kurdishfella]

I also ordered some tianeptine im gonna try It reduces serotonin.

I have tried cyproheptadine but did nothing for me it doesen't reduce the serotonin in your body just blocks the effect.

[iseethelight]

eating a low tryptophan would be too difficult for me.

 

 

 

 

Im now trying to find a solution to make my MAO-A more active as it breaks down serotonin etc.

 

i wanna get to the problem what causes my high serotonin. All I know is my genes make it so  I end up with  more serotonin. I suspect I have something called Brunner syndrome (warrior gene) 

 

''Brunner syndrome is a rare genetic disorder associated with a mutation in the MAOA gene.

Brunner syndrome is caused by a monoamine oxidase A (MAOA) deficiency, which leads to an excess of monoamines in the brain, such as serotonin, dopamine, and norepinephrine(noradrenaline). In both mice and humans, a mutation was located on the eighth exon of the MAO-A gene, which created a dysfunctional MAO-A gene. The regular function of MAO-A, breaking down monoamines, is disrupted, and monoamines build up within the brain. Mice that lacked a functional MAO-A gene displayed higher levels of aggression, in comparison to mice with a functional MAO-A gene

Characteristic biochemical abnormalities included high serum serotonin .

Symptomatic individuals have particularly high serotonin levels, and treatment with a serotonin reuptake inhibitor and dietary modification resulted in reversal of biochemical abnormalities, reduction of 'serotonergic' symptoms and behavioural improvement.''

 

 

Might try something like Apigenin , Luteolin or Valproic Acid

 

https://www.ncbi.nlm...pubmed/19815045

 

https://www.ncbi.nlm...les/PMC3187529/

 

 

I have confirmed that I have the MAOA R297R Gene mutation. It's not as extreme as this brunner syndrome , as it's just a slow functioning MAO-A/B but it also results in excess monoamine neurotransmitters. You can do a 23andme and run your results thru one of the online gene things like geneticgenie to look for particular mutations.

 

BCAAs tend to help me but can also put me in a dull mood . It goes from excess to not enough with bcaa but it's. I also tried riboflavin which is supposed to speed up MAO but it made me more depressed. What we need is balance, which is hard to achieve. 

[kurdishfella]

 

eating a low tryptophan would be too difficult for me.

 

 

 

 

Im now trying to find a solution to make my MAO-A more active as it breaks down serotonin etc.

 

i wanna get to the problem what causes my high serotonin. All I know is my genes make it so  I end up with  more serotonin. I suspect I have something called Brunner syndrome (warrior gene) 

 

''Brunner syndrome is a rare genetic disorder associated with a mutation in the MAOA gene.

Brunner syndrome is caused by a monoamine oxidase A (MAOA) deficiency, which leads to an excess of monoamines in the brain, such as serotonin, dopamine, and norepinephrine(noradrenaline). In both mice and humans, a mutation was located on the eighth exon of the MAO-A gene, which created a dysfunctional MAO-A gene. The regular function of MAO-A, breaking down monoamines, is disrupted, and monoamines build up within the brain. Mice that lacked a functional MAO-A gene displayed higher levels of aggression, in comparison to mice with a functional MAO-A gene

Characteristic biochemical abnormalities included high serum serotonin .

Symptomatic individuals have particularly high serotonin levels, and treatment with a serotonin reuptake inhibitor and dietary modification resulted in reversal of biochemical abnormalities, reduction of 'serotonergic' symptoms and behavioural improvement.''

 

 

Might try something like Apigenin , Luteolin or Valproic Acid

 

https://www.ncbi.nlm...pubmed/19815045

 

https://www.ncbi.nlm...les/PMC3187529/

 

 

I have confirmed that I have the MAOA R297R Gene mutation. It's not as extreme as this brunner syndrome , as it's just a slow functioning MAO-A/B but it also results in excess monoamine neurotransmitters. You can do a 23andme and run your results thru one of the online gene things like geneticgenie to look for particular mutations.

 

BCAAs tend to help me but can also put me in a dull mood . It goes from excess to not enough with bcaa but it's. I also tried riboflavin which is supposed to speed up MAO but it made me more depressed. What we need is balance, which is hard to achieve. 

 

yes actually the 23andme package  i ordered came today but i havent opened it yet.

I tried BCAA didnt work for me . riboflavin I had no idea sped ud MAO.. might give that a shot too.

Edited by farshad, 13 July 2017 - 05:53 PM.

[gamesguru]

guys, try zinc and magnesium.  preferably liquid form, doesn't take much about 8mg and 125mg respectively to yield the harmonizing and meditative state of mind about with the topic starter is so incredulous.  affecting every system from adenosine to the HPA it's no surprise these humble metals can be of serious utility for people with depression or anxiety

 

the suggestion for luteolin is backed by at least one study, which also gave cause for quercetin^[1]

Edited by gamesguru, 14 July 2017 - 12:34 AM.

[neurobliss]

I know this is an old thread but if you are still searching for answer - Raowolscine would speed up your MAO-A. I can't remember now where I read it but there is a guy who posted somewhere online that he went from being highly aggressive to very mellow by taking that supplement and he also had the warrior MAO type.

[dramachiavellian]

cyproheptadine is a broad spectrum serotonin antagonist although it doesn't actually decrease serotonin production/plasma serotonin.

 

for you personally though, OP, i'd recommend a tranquilizer dart to the jugular. 

Edited by dramachiavellian, 04 March 2018 - 11:52 AM.

[iseethelight]

 

for you personally though, OP, i'd recommend a tranquilizer dart to the jugular. 

Hahahaha

 

I've come to the realization that serotonin cannot be decreased safely. BCAA + tyrosine is  the best bet but timing is crucial, taking them together doesn't seem to work.