I recently did a 23andme genetic test and plugged it into genetic genie to get my mutations.
A brief history on me; I'm a 29 year old male who has suffered from bipolar depression, OCD and ADHD PI with low motivation despite having hobbies that I love to do. I've struggled with drive despite having such a strong desire to achieve so much and it pains me because I know I'm not lazy. I've had periods of my life where I was firing on all cylinders in regards to my goals. I've got a good growth mindset and thats helped me.
I was taking lithium carbonate for 6 years (1200mg) and it helped immensely with my motivation and anhedonia. I was able to pursue my dreams and not feel unmotivated. I've been off lithium for a year now to due me being scared for my kidneys and thyroid and since then my motivation has been stifled and the anhedonia has come back. I've tried lithium orotate and it doesnt seem to work like carbonate did.
So I decided to try some genetic testing and see what I can do about it through natural supplementation rather than relying on pharmaceuticals. I've been reading about methylation and decided to get my genes tested through 23andme and lo and behold, I have an mthfr defect (homozygous for C677T).
The issue is though whenever I take methylfolate in higher than 400mcg doses, I get extremely depressed. Like a serotonin deficiency like depression. I feel sad and crave sugar. I've even tried it with methylcobalamin and its worse, and with hydroxyb12.
I do eat a lot of vegetables and my diet is on point for the most part. Do I need to supplement with methylfolate even if I do have this mutation?
So basically my issue is that I don't want to feel anhedonic and low motivation, yet when I try methylfolate, I get worse. Any suggestions?
Any help is greatly appreciated. I was thinking about going back on psychiatric medication.
Here are my mutations
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO-A R297R rs6323 TT +/+
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AA +/+
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 GG +/+
MTRR H595Y rs10380 __ no call
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 __ no call
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 __ no call
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 CT +/-
AHCY-02 rs819134 __ no call
AHCY-19 rs819171 CT +/-
CBS C699T rs234706 AG +/-
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 __ no call
SHMT1 C1420T rs1979277 __ no call
Edited by Squallor, 14 July 2017 - 08:22 AM.