Hi.
I'm 26 yo.
Since 22 i suffered of depression
.
I've been cyclically in the tunnel (6month in, 6 month out) but i'm not diagnosed Bipolar.
Now i'm out the tunnel for the 3rd time and use my energy to prevent another episode
I suffered of strong suicidal thoughts and, also if i feel good now, i know depression will be return and if i don't do something NOW, suicidal behavior will worsen later during years.
I've tryed 4 SSRI's.
It seems Fluoxetine and Venlafaxine did something but i cannot be sure at all and if they worked they started only after 3months.
Too much time and too many "suicidal crysis" in between.
I'm know pharmacology and the limits of the therapeutical effects of actual antidepressant terapies.
At least, considering this and considering my personal history, i thought the better way is prevention and work over my brain with a full-spectrum therapy based over the last researches.
This is a bet. Side effects of drugs could bring me to a lowered quality of life then using standard treatment.
Personally i don't believe so no more.
Suicidal crysis were so strong in the past that i decide to run the risk.
So this is my actual\next therapy. It acts over different biological way, based over last recent research:
1)Serotoninergic way: Venlafaxine 70mg\day (standard dosage)
2)Glutamatergic way: Sarcosine 2gr\day
3)"Neurotrophic way": NSI-189
4)another gutamatergic way: R-ketamine
Don't wanna mix too many drugs (because of possible interactions and sides) so i'm testing combinations of two drugs per time.
The route:
Venlafaxine: ever. SSRIs are the major studied drug for depression so i consider it my main therapy.
Sarcosine&NSI-189: people use to cycle NSI 3-4 times\year. During non-NSI period i will substitute it with Sarconsine instead of taking nothing else.
Working over hyppocampus trophysm i hope NSI to revert depression hyppocampal damage and so lower the probability of fall again in depression.
R-ketamine: because of its rapid effect (hours) i will use it to fight depression if it will come again. It is also supposed to be effective against suicidal behavior\thoughts. It is possible to use R-ketamine weekly to prevent depression but as of now i feel more appropriate to do Sarcosine&NSI-189 cycle for prevention purposes.
Last notes:
1) as of now i'm under Venlafaxine+Sarcosine therapy. Never tryed NSI and R-ketamine but i'm working to get them.
2) everything i wrote it is based on a scientific base but in the end they become from my personal evalutions and my personal history.
3) i'm a MD and i know pharmacology, anyway cure on itself is never safe. I know what i'm doing and i don't encourage none to do what i do. I just wrote a report end interested to discuss over it.
Thanks for your time.