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Another rapamycin mouse study (females) shows life extenstion

rapamycin in vivo

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#1 malbecman

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Posted 07 August 2017 - 04:27 PM


 I've not had time to read all the details

 

J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):876-81. doi: 10.1093/gerona/glw064. Epub 2016 Apr 18.
Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice.
Abstract

Inhibition of the mTOR (mechanistic target of rapamycin) signaling pathway by the FDA-approved drug rapamycin promotes life span in numerous model organisms and delays age-related disease in mice. However, the utilization of rapamycin as a therapy for age-related diseases will likely prove challenging due to the serious metabolic and immunological side effects of rapamycin in humans. We recently identified an intermittent rapamycin treatment regimen-2mg/kg administered every 5 days-with a reduced impact on glucose homeostasis and the immune system as compared with chronic treatment; however, the ability of this regimen to extend life span has not been determined. Here, we report for the first time that an intermittent rapamycin treatment regimen starting as late as 20 months of age can extend the life span of female C57BL/6J mice. Our work demonstrates that the anti-aging potential of rapamycin is separable from many of its negative side effects and suggests that carefully designed dosing regimens may permit the safer use of rapamycin and its analogs for the treatment of age-related diseases in humans.

© The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

KEYWORDS:

Anti-aging; Life span; Mice; Rapamycin; mTOR  PMID:27091134

 

https://academic.oup...3/gerona/glw064


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#2 tintinet

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Posted 07 August 2017 - 07:16 PM

Thanks- I've been on a 5 mg q 5 day schedule for a while now.
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