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Memantine's effects on GABA & NMDA receptors

memantine gaba nmda anxiety pain brain opioids benzodiazepines

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#1 HelpMeOut

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Posted 11 August 2017 - 02:32 AM


I have taken Memantine several times during my benzo and opioid withdrawal. It greatly helped with my nerve pain and I am not sure why exactly.

 

I consider it to take it again as I suspect that the pain that is caused when I take opioids may have to do with NMDA overactivity, especially

since I have stopped benzos at the beginning of the year.

 

However, I have a question about Memantine's effect on GABAA and NMDA receptors.

 

Memantine is a non competitive NMDA receptor antagonist. Does this mean that prolonged treatment with Memantine will upregulate

NMDA receptors to counter the antagonism?

 

I am also wondering how Memantine affects GABAA receptors and GABA transmission in general especially since it's a weak D2 agonist.

Will it rather lower or increase GABA transmission? I can't find any research on this. But normally, increased dopamine means decreased

GABA, right?

 

I hope someone with knowledge chimes in! :)

 

Kind regards

HMO



#2 normalizing

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Posted 12 May 2018 - 04:06 PM

i wonder this too but it seems people on this forum arent that educated to know such thing as it is evident by the lack of replies



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Also tagged with one or more of these keywords: memantine, gaba, nmda, anxiety, pain, brain, opioids, benzodiazepines

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