I have taken Memantine several times during my benzo and opioid withdrawal. It greatly helped with my nerve pain and I am not sure why exactly.
I consider it to take it again as I suspect that the pain that is caused when I take opioids may have to do with NMDA overactivity, especially
since I have stopped benzos at the beginning of the year.
However, I have a question about Memantine's effect on GABAA and NMDA receptors.
Memantine is a non competitive NMDA receptor antagonist. Does this mean that prolonged treatment with Memantine will upregulate
NMDA receptors to counter the antagonism?
I am also wondering how Memantine affects GABAA receptors and GABA transmission in general especially since it's a weak D2 agonist.
Will it rather lower or increase GABA transmission? I can't find any research on this. But normally, increased dopamine means decreased
GABA, right?
I hope someone with knowledge chimes in!
Kind regards
HMO