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High Fat low protein doubles lifespan, High Carb low protein triples it

diet carb fat protein high fat diet high carb diet low protein diet longevity lifespan life extension

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#1 iseethelight

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Posted 07 September 2017 - 03:06 AM


In Mice prone to autoimmune diseases. So it looks like the less protein you consume the healthier you get. Methionine restriction? Less ammonia production? Less oxidative stress?

Discuss...

 

 
Crucial dietary factors in maximizing life span and longevity in autoimmune-prone mice.
Abstract

When the energy intake of (NZB X NZW)F1 female mice was reduced to 60% of the intake of simultaneously ad libitum-fed mice, the early death associated with autoimmune-based renal disease in this strain was greatly delayed. The length of prolongation of disease-free life depended not only on the decreased energy intake but also on the energy source. In the group of mice with 60% intake of a carbohydrate-free (i.e., high fat) diet, mean longevity was doubled as compared to that of ad libitum-fed mice. However, when the nonprotein energy was supplied by carbohydrate (sucrose and glycerol) the mean longevity was three times that of the ad libitum-fed groups, although survival times varied widely. With ad libitum feeding the nonprotein energy source did not significantly affect longevity. Clearly, although energy intake restriction provides significant influence on longevity, very high fat diets do not give the same protection as do high carbohydrate diets. The basis for this difference is not entirely clear and several explanations are possible.

PMID:   3598724
[Indexed for MEDLINE]
 

 

 



#2 joelcairo

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Posted 07 September 2017 - 07:52 PM

These mice were bred to die from autoimmune-based renal disease. Doesn't it make sense that a low protein diet would be beneficial? I'm not sure this can be generalized.


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#3 Turnbuckle

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Posted 07 September 2017 - 08:09 PM

These mice are very short lived. The average lifespan for NZBWF1 is 245 days for females and 406 days for males. 

https://www.jax.org/strain/100008


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