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Where Can I get My Test Results Analyzed?

brain fog depression anxiety fatigue

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#1 KieranA001

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Posted 12 September 2017 - 10:30 AM


Hi, 

 

Basically I've been blowing my money my whole life trying to find a way to cure or find out what's causing my brain fog, depression, anxiety and poor memory so instead I've gone down the route of blood tests to rule out specific disorders / hormonal imbalances. I have attached a few below, and have added a quote from a woman who did a bit of the analysing for me but I cannot interpret all of it. I've been trying to find a way to help myself for ages now with no luck. 

Good afternoon Kieran,

Apologies with the delay in getting back to you.
I had a look at the genetic information from 23 and me that you sent over to me previously and from what I read and interpreted from that, there were a number of genetic mutations which could be potential contributors to some of the symptoms you had described as well as reasons for vitamin and mineral deficiencies. 

Please find below the information from your 23 and me and my conclusion at the end...

MTHFR C677T Mutation:
One function of MTHFR (Methylenetetrahydrofolate reductase) is to help convert homocysteine to methionine. A
MTHFR C677T mutation means that the MTHFR enzyme may have trouble performing its task leading to high levels
of homocysteine, impaired function of the enzyme can cause or contribute to conditions such as Autism, Chronic Fatigue Syndrome, Fibromyalgia, IBS, Multiple Sclerosis, Alzheimer's, Bipolar Disorder, blood clots, Stroke, Chemical Sensitivity, and many other conditions.
MTHFR C677T can also lead to high homocysteine. High levels of homocysteine can be related to MTHFR C677T
mutations. 

As S-adenosylhomocysteine (SAH) accumulates, the COMT enzyme may become impaired. Inhibitiion of COMT can
increase dopamine levels in COMT V158M (-/-), but for those with COMT V158M (+/+), the high level of SAH can lead
to behavior problems and mood swings. 

It may be worth having a cortisol test/homocystein levels test to see how yours is functioning at present as this may explain symptoms of fatigue and mood changes during the day. Cortisol levels will indicate how your body deals with stress as well.

Here are your homozygous and heterozygous mutations as indicated in your SNP gene table above (not including MTHFR):

CBS C699T & CBS A360A Mutations:
CBS (cystathionine beta synthase) catalyzes the first step of the transsulfuration pathway, from homocysteine to
cystathionine. CBS defects are actually an upregulation of the CBS enzyme. This means the enzyme works too fast.
In these patients, it's common to see low levels of cystathionine and homocysteine since there is a rapid conversion
to taurine. This leads to high levels of taurine and ammonia. 
The CBS upregulation has been clinically observed to result in sulfur intolerance in some patients. It has also been observed that BH4 can also become depleted with a CBS upregulation. BH4 helps regulate neurotransmitters and mood.
Other mutations, such as MTHFR A1298C, Chronic bacterial infections, and aluminum can also lead to low BH4 levels. Lack of BH4 can lead to mast cell degranulation and possibly mast cell activation disorder (MCAD).

MTRR A66G & MTRR A664A Mutations:
MTRR (Methionine synthase reductase) helps recycle B12. The combination of MTR and MTRR mutations can
deplete methyl B12. MTR A2756G, MTRR A66G, MTRR H595Y, MTRR K350A, MTRR R415T, MTRR S257T, and
MTRR A664A all work together to convert homocysteine to methionine.
MTR (5-methyltetrahydrofolate-homocysteine methyltransferase) provides instructions for making the enzyme
methionine synthase. Methionine synthase helps convert the amino acid homocysteine to methionine. 
To work properly, methionine synthase requires B12 (specifically in the form of methylcobalamin). 
An MTR A2756G mutation increases the activity of the MTR gene causing a greater need for B12 since the enzyme causes B12 to deplete since it is using it up at a faster rate. Mutations in MTR have been identified as the underlying cause of methylcobalamin
deficiency. 
Megaloblastic anemia can occur as a consequence of reduce methionine synthase activity.
A homozygous mutation of MTR A2756G is not very common (<1% of CEU population). Some studies have
demonstrated that people with a combination of MTHFR C677T and MTR A2756G have persistently high
homocysteine levels unless they are treated with both B12 and folate.


COMT V158M & COMT H62H Mutations:
COMT (catechol-O-methyltransferase) helps break down certain neurotransmitters and catecholamines. These include
dopamine, epinephrine, and norepinephrine. Catechol-O-methyltransferase is important to the areas of the pre-frontal
cortex. This area of the brain is involved with personality, inhibition of behaviors, short-term memory, planning,
abstract thinking, and emotion. COMT is also involved with metabolizing estrogens.
COMT (-/-) individuals can usually break down these neurotransmitters efficiently, but COMT (+/+) individuals may
have trouble breaking these chemicals down from impaired function of the enzyme. With a COMT + status, it has
been clinically observed by physicians that people may have trouble with methyl donors. This can lead to irritability,
hyperactivity, or abnormal behavior. They may also be more sensitive to pain.

VDR Taq Mutation:
VDR (Vitamin D Receptor) encodes the nuclear hormone receptor for vitamin D3. Low or low normal vitamin D values
are often seen in those with chronic illness and even the general population. Low vitamin D is related to a lot of
neurological and immunological conditions. Vitamin D stimulates enzymes that create dopamine.
VDR Tak and VDR Bsm are usually inverse from eachother. So if there is a (+/+) VDR Tak, there would be a (-/-) VDR
Bsm. However, this is not always the case.
It has been clinically observed that the body may have trouble tolerating methyl donors with a COMT V158M + and a
VDR Taq + status. VDR Taq (-/-) individuals may already have higher levels of dopamine, and combinations of
variations COMT and VDR Taq can lead to a wide range of dopamine levels. Those that are VDR Taq (+/+) and
COMT (-/-) may have lowest dopamine levels.

BHMT-08 & BHMT-02 Mutation:
BHMT (betaine homocysteine methyltransferase) acts as a shortcut through the methylation cycle helping convert
homocysteine to methionine. The activity of the enzyme can be negatively influenced by stress. The Information on
this enzyme related to methylation is mostly based on Dr. Amy Yasko's clinical experience and research.
A homozygous mutation of BHMT 01, BHMT 02, BHMT 04, can produce results similar to one with a CBS upregulation even if you don't have a CBS upregulation. A BHMT 08 mutation may "increase MHPG levels relative to dopamine breakdown (HVA)". This
can result in attention type symptoms. It is common to see elevated glycine in someone with a homozygous BHMT
08 mutation.


I believe the best treatment would be with vitamin B12 and folate as the CBS genetic mutation leads to an over use of vitamin B 12 which can cause deficiency. It may also help to regulate energy levels and mood. As your results for vitamin B12 came back sufficient, can I ask are you or have you recently been supplementing with vitamin B 12? Your results for folate however did come back deficient so supplementing and incorporating foods into your diet will be beneficial. 

The genetic mutations have also been linked to megloblastic anaemia so supplementing with folate and iron would help with this, as well as vitamin D during winter months. 

It also suggests that you may be more prone to chemical sensitives, so avoiding processed foods and limiting exposure to chemical would be beneficial.  

As you magnesium levels are quite low I would supplement initially but also incorporate foods which contain magnesium.
We can go into the food sides of things in another email.

Your potassium levels are within normal range but are towards the high end, so with regards to supplements containing this, I would try and avoid. 

Iron levels were border line normal, so again as I said previously with regards to your genes, its worth either supplementing or incorporating these foods into your diet. 

Cobalt levels were right on the border of being low, again worth looking into foods to incorporate into your diet. 

Chromium, manganese, selenium are within normal range but worth keeping an eye on as again they are borderline low.  

Hope this wasnt too over whelming.. let me know your thoughts and whether you need anything going into further.

If you wish to progress with the purchase of anything else, please let me know before doing so, so I can advise you,

Thank you.

Attached Files


Edited by KieranA001, 12 September 2017 - 10:34 AM.






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