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An Interview with Greg Fahy on Thymus Rejuvenation


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#1 reason

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Posted 05 October 2017 - 12:18 PM


Greg Fahy is currently wrapping up a trial of one of the simpler methods that might produce some degree of rejuvenation in the the thymus, turning back a little of the process of thymic involution, the withering of functional tissue in this organ. The thymus atrophies quite early in adult life, and further with later aging. As the thymus provides an environment for processes that are necessary in the creation of the immune cells called T cells, this decline limits the immune system. A faster pace of creation for T cells should help with some of the age-related deterioration of the immune system, which arises in part because too many of the existing cells become dysfunctional, and because the pace of replacement is too slow to keep up.

I think that this trial is unlikely to be enormously effective at addressing the problem, and will probably only produce modest effects, but the point of the exercise is to prove in humans that any degree of thymic restoration can produce a commensurate level of benefits. If that can be accomplished via this approach, then hopefully funds can be found to bring one of the more effective methods demonstrated in mice into human medicine: FOXN1 gene therapy, tissue engineering and transplant of replacement thymic tissue, some form of cell therapy to spur regeneration of new thymus tissue, and so forth.

So from around age 20 (or younger) the thymus begins to shrink and loses the ability to produce T cells, why does this happen?

Nobody knows why thymic atrophy, or involution, occurs, but it happens in all vertebrates, starting really at the age of puberty. Some have suggested that it happens to save energy, since the production of properly qualified T cells is very energy intensive and inefficient, and of course, at puberty, the body begins to devote more energy to reproduction, which might require a tradeoff against using energy for immune maintenance. This could be adaptive since, in nature, humans would not have lived long enough for immune system collapse to set in, even though today, the situation is different. Regardless of the evolutionary reason for it, the most immediate biochemical cause of involution seems to be mostly a drop in thymic FOXN1 expression, although some have pointed to a decline in intra-thymic IL-7 and the negative influence of circulating sex hormones, for example.

You recently ran a human clinical trial to regrow the thymus gland. Can you please tell us what is the main goal of the project and what is the progress?

The trial was conducted under an FDA-approved IND and with review from multiple scientific and ethics committees. It consisted of a 12-month treatment course for 9 men divided into two cohorts, with the first cohort starting in October of 2015 and the second ending in April of this year. Our goal was to gather preliminary evidence indicating that it is possible to safely regenerate the normal aging human thymus and restore its functions, essentially reversing the process of age-related immunological deterioration. We chose to work with healthy men in part because this was a small trial, which required a reasonably uniform population, and in part because more information was available for men than for women. We chose an age range of 50 to 65 years because this range extends from several years before to a few years after the threshold age at which the immune system tends to collapse. Success would therefore suggest the possibility of preventing or even reversing the early stages of immune collapse. In future trials, we intend to enroll both women and older men.

The outcome measures included MRI evaluation of thymic density before and after treatment, simple and sophisticated assessment of T cell population distributions, measurements of many serum factors related to immune system function and general health, lymphocyte telomere length distributions and telomerase activity, and biological age based on the Horvath epigenetic clock. Regarding our results, first of all, when you're working with human beings, safety has to be the top priority, so I'm glad to be able to say that we met or exceeded all of our safety targets. Regarding thymic imaging results, preliminary analyses indicate that there was a consistent and substantial increase in thymic density, which indicates replacement of thymic fat with more water-rich material, and in previous studies on human immunodeficiency patients, this coincided with improved thymic function. Superficial tests of immune system aging showed improvements in 8 out of 9 men, and we were able to identify a possible correctable reason for the failure of the 9th volunteer. Men of all ages were able to respond positively and to avoid side effects. However, the most definitive endpoints of our study are still being analyzed at four different locations around the world, so we won't really know the final results of our study for probably another month or two.

Are we going to see a publication anytime soon?

I'm not sure about soon, but certainly, as soon as we can. This will be a complicated paper with lots of authors and lots of data to present, but also with top-tier academic co-authors who can help us go through the scientific review process quickly. In any case, we certainly want to make sure that any novel results are shared with the broader medical and scientific communities.

Link: https://www.leafscie...ing-the-thymus/

View the full article at FightAging


#2 Rocket

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Posted 06 October 2017 - 01:10 AM

This is the hgh + DHEA regime.

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#3 Believer

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Posted 18 October 2017 - 11:07 PM

This is the hgh + DHEA regime.

Why when melatonin is repeatedly claimed to be able to do it efficiently? Melatonin is much easier to get one's hands on.

 



#4 maxwatt

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Posted 30 October 2017 - 10:53 PM

There is a difference in exogenous and endogenous HGH.  With age the ability to produce growth hormone declines, though some residual capability may remain.

 

Besides melatonin, other HGH releasers include certain amino acids(taken on an empty stomach) including glycine, arginine and ornithine. 



#5 Believer

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Posted 01 November 2017 - 04:13 PM

There is a difference in exogenous and endogenous HGH.  With age the ability to produce growth hormone declines, though some residual capability may remain.

 

Besides melatonin, other HGH releasers include certain amino acids(taken on an empty stomach) including glycine, arginine and ornithine. 

As with testosterone, prolactin, growth hormone and other hormones you can elevate using amino acids and vitamins, the effect of increased hormone levels lasts for at most 1-2 hours and is weak.

 


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#6 maxwatt

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Posted 02 November 2017 - 12:56 AM

It's better than nothing, if you are not willing or able to get hormone injections from your doctor or neighborhood gym rat.  And perhaps 1 to two hours is enough

 



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#7 albedo

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Posted 04 January 2018 - 09:30 AM

I would be curious to know if Greg Fahy's is the FOXN1 protocol Josh Mitteldorf enrolled in.

There was an article on the LEF magazine too: http://www.lifeexten...eversal/Page-01



#8 albedo

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Posted 28 February 2018 - 06:27 PM

This is the hgh + DHEA regime.

 

"...So Fahy decided to regrow his own thymus using growth hormone and DHEA.  Yep.  He just performed an N=1 experiment by himself, on himself.  It was very difficult and expensive though.   First of all, HGH (human growth hormone) blocks insulin function.  So that’s a problem.  Fahy figured out that DHEA counteracts this effect.  He speculated that the high HGH levels in young people didn’t impact their insulin function due to high levels of DHEA.  DHEA has a plethora of other beneficial side effects, so that was a win win situation..."

http://oaklandfuturi...h.YOQSUFvI.dpbs

 

Is the above what you meat in your post Rocket?
 



#9 Rocket

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Posted 01 March 2018 - 01:54 AM

This is the hgh + DHEA regime.


"...So Fahy decided to regrow his own thymus using growth hormone and DHEA. Yep. He just performed an N=1 experiment by himself, on himself. It was very difficult and expensive though. First of all, HGH (human growth hormone) blocks insulin function. So that’s a problem. Fahy figured out that DHEA counteracts this effect. He speculated that the high HGH levels in young people didn’t impact their insulin function due to high levels of DHEA. DHEA has a plethora of other beneficial side effects, so that was a win win situation..."
http://oaklandfuturi...h.YOQSUFvI.dpbs



Is the above what you meat in your post Rocket?

Not that specific article, but that is essentially it. I thought this experiment was more known than apparently it is.

A year or two ago I was in the google patents site and found a patent for thymus regeneration with hgh and DHEA to protect against the insulin effect. I don't remember if it was Greg's or not but I think it was.

Even if this works because of the DEA in the states it will never see the light of day, because don't you know hgh is classified with drugs like cocaine and heroine. We can't have people aging in good health in the US maintaining some muscle mass and bones not as brittle as glass.
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#10 mike20g

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Posted 06 September 2019 - 08:08 PM

Looks like this is an outcome:

 

https://www.nature.c...586-019-02638-w

 

 

Found this in the comments section here:

http://interveneimmu...the-triim-trial

 

Intervene

Thanks a lot for your comment. We haven’t disclosed the full regimen for the TRIIM trial publicly, only to our trial volunteers, but we will say that we are using all FDA-approved drugs. The TRIIM trial and the regimen are part of a clinical study that aims to regenerate the thymus and immune system, while also controlling or mitigating common side effects of these medications, and a primary goal is to help firmly establish the appropriate dosing, length of time necessary, and other individual factors such as diet and health status that may influence its efficacy. But one of the very exciting aspects of the trial is that once these aspects are worked out (and they are being worked out now, i.e. as we conduct the trial, enroll more patients, and conduct more tests), physicians and patients can readily use this information and implement a similar treatment regimen for themselves.

 

This can help guess what was used in the study:

https://www.lifespan.io/hgh-dhea/

 

use of human growth hormone (HGH) and dehydroepiandrosterone (DHEA) to regrow the thymus.

Likely added metformin.

 

 


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