• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
LongeCity .                       Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Questions on Reveratrol and Other Stilbenoids

resveratrol pterostilbene stilbenoid dosage dose synergy megaresveratrol

  • Please log in to reply
3 replies to this topic
⌛⇒ LongeCity grant support for self-testing

#1 recon

  • Registered User
  • 73 posts
  • 7

Posted 21 October 2017 - 02:15 AM


Hi,

 

I have several questions about resveratrol and other stilbenoids such as pterostilbene. I have done some small looking-up but I may be very wrong in my conclusions so I need your expertise on this. I hope this will stimulate some well-needed discussions in this dying subforum.

 

1) What is the optimal dosage for resveratrol? (high-dose vs low-dose)

 

Studies seem to converge towards lower dosage compared to higher dosage. I have not yet look into what constitutes a higher dosage compared to a lower dosage since I lack the knowledge of metabolic conversion from rat dosing to human dosing. Still, the bioavailability of resveratrol is so low that maybe a high-dose may be require to even have a low-dose bioavailability.

 

 

Cho, Su-Jung, Un Ju Jung and Myung-Sook Choi. "Differential effects of low-dose resveratrol on adiposity and hepatic steatosis." British Journal of Nutrition 108.12 (2012): 2166–2175. 20 October 2017.

<https://doi.org/10.1...7114512000347>.

"A low dose of RV (0·005 %) appeared to be more effective than a higher dose of RV (0·02 %) for suppressing adiposity and hepatic steatosis development with a significant decrease in body weight gain, plasma TAG and total cholesterol levels."

 

Effects of resveratrol on body weight and food intake in diet-induced obese mice -

"In HFD-fed mice, supplementation of RV at a low dose (0·005 %) significantly suppressed body weight gain after 3 weeks, but the higher dose of RV (0·02 %) was surprisingly not effective [...]"

 

Effects of resveratrol on fat accumulation in diet-induced obese mice -

"Only the low dose of RV (0·005 %) effectively reduced the weight of the epididymal and retroperitoneal adipose depots in HFD-fed mice (Fig. 1). Hence, overall total visceral adipose weight was significantly lowered by RV supplementation, although the low dose appeared to be more effective than the higher dose [...]"

 

Effect of resveratrol on plasma and hepatic lipid levels in diet-induced obese mice -

"Remarkably, RV was more effective at a low dose (0·005 %), but not at a higher dose (0·02 %), for reducing plasma TAG and total cholesterol levels in HFD-fed mice. [...]

RV caused a marked decrease in the number and size of liver fat droplets, and the low dose of RV (0·005%) appeared to be more effective than the higher dose of RV (0·02 %)."

 

 

Pearson, Kevin J., et al. "Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan." Cell Metabolism 8.2 (2008): 157–168. 20 October 2017.

<https://dx.doi.org/1...t.2008.06.011>.

 

 

Survival -

"In the lower-dose (HCLR) group, maximum life span was also increased, while this effect did not reach significance for the higher dose (HCR) [...]"

 

"While the HCR group had a very slight decrease in body weight that was not statistically significant, the HCLR group displayed a significant increase in body weight, despite consuming a similar amount of food [...]"

 

 

2) Should resveratrol be taken with meal?

 

I find that this is irrelevant. I take it along with meal as to take it with niacin and others. I hope for resveratrol to activate NAMPT. Given that I take resveratrol with meal, a standard meal seems to be better than a high-fat one.

 

Vaz-da-Silva, M, et al. "Effect of food on the pharmacokinetic profile of trans-resveratrol." Int J Clin Pharmacol Ther. 46.11 (2008): 564-70. 20 October 2017. <https://www.ncbi.nlm...bmed/19000554>.

"The rate of absorption of trans-resveratrol following an oral 400 mg single-dose was significantly delayed by the presence of food, as reflected by Cmax and tmax. However, the extent of absorption, as reflected by AUC- yen, was not affected in a relevant way."

 

la Porte, C, et al. "Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects." Clin Pharmacokinet. 49.7 (2010): 449-54. 20

October 2017. <https://doi.org/10.2...0000000-00000>.

 

"In order to maximize trans-resveratrol exposure, it should be taken with a standard breakfast and not with a high-fat meal."

 

 

3) What should be taken along with resveratrol?

 

Leucine - synergistic effect to Sirt1

https://www.ncbi.nlm...pubmed/22913271

 

NAD+ precursors - the precursors convert to NAM in the intestine and NAMPT converts them back, and resveratrol seems to activate NAMPT.

 

 

4) What is the optimal dosage for pterostilbene?

 

Pterostilbene seems to be the same as resveratrol.

"a bell-curve that may favor lower dosages such as is found in food consumption rather than higher dosages from supplementation."

https://examine.com/.../pterostilbene/

 

This is my primary question that I want to know. 50 mg is sold everywhere but MegaResveratrol sold at around 250 mg. That is 5x the dosage per supplementation. Should I be taking that much?

 


Edited by recon, 21 October 2017 - 02:16 AM.


#2 maxwatt

  • Member, Moderator LeadNavigator
  • 4,895 posts
  • 1,577
  • Location:New York

Posted 02 November 2017 - 12:49 AM

recon wrote "should I be taking that much?"

 

As he pointed out from the studies he cited, there is a U-shaped dose/response curve for many of the effects.  But it depends on what your goal is on taking these, or any supplement.

 

https://www.ncbi.nlm...les/PMC5610395/ showed greater glucose control in human type 2 diabetics with resveratrol at doses greater than 100 mg vs under 100 mg.

 

Self experimenters in this forum found exercise benefits in highly trained athletes at doses of 400 mg; studies looking for this effect at lower doses found none.

 

There are many other such if you look for them.  So determine what you wish to achieve and tune the dosage to achieve that effect.  Hopefully with an objective measure, such as blood work before,during and after.  Or a bicycle power meter to measure your output, or time to complete a fixed distance running course. And with a competent coach to help you  sort out  the effect from the training effect one might expect with an exercise program.  Et cetera.

 

 



sponsored ad

  • Advert
Click HERE to rent this advertising spot to support LongeCity (this will replace the google ad above).

#3 recon

  • Topic Starter
  • Registered User
  • 73 posts
  • 7

Posted 04 November 2017 - 12:42 AM

recon wrote "should I be taking that much?"

As he pointed out from the studies he cited, there is a U-shaped dose/response curve for many of the effects. But it depends on what your goal is on taking these, or any supplement.

https://www.ncbi.nlm...les/PMC5610395/ showed greater glucose control in human type 2 diabetics with resveratrol at doses greater than 100 mg vs under 100 mg.

Self experimenters in this forum found exercise benefits in highly trained athletes at doses of 400 mg; studies looking for this effect at lower doses found none.

There are many other such if you look for them. So determine what you wish to achieve and tune the dosage to achieve that effect. Hopefully with an objective measure, such as blood work before,during and after. Or a bicycle power meter to measure your output, or time to complete a fixed distance running course. And with a competent coach to help you sort out the effect from the training effect one might expect with an exercise program. Et cetera.


Thanks maxwatt! I’m trying to determine the best dosage for just mere Sirtuin activation. Just worried that pterostilbene and resveratrol may work in some sort of a feedback system that will eventually downregulate things.

And, what about you?
Do you take pterostilbene or resveratrol? How much and how do you take them? What’s your rationale?

sponsored ad

  • Advert
Click HERE to rent this advertising spot to support LongeCity (this will replace the google ad above).

#4 maxwatt

  • Member, Moderator LeadNavigator
  • 4,895 posts
  • 1,577
  • Location:New York

Posted 04 November 2017 - 03:37 AM

PM me if you want to discuss this







Also tagged with one or more of these keywords: resveratrol, pterostilbene, stilbenoid, dosage, dose, synergy, megaresveratrol

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users