If you were a 4'10, 97 pound woman, how much NR would you take? Asking for a friend.
Posted 03 November 2017 - 10:15 PM
If you were a 4'10, 97 pound woman, how much NR would you take? Asking for a friend.
Posted 04 November 2017 - 02:17 PM
Lena,
No-one really knows how much the recommended dosage varies between individuals, but most people believe that young people would see much less benefit, while older, sicker people have less NAD+ available and would benefit from a higher dosage.
So, bodyweight matter, but age and health probably a lot more so.
Posted 05 November 2017 - 04:52 AM
How young do you think one should begin NR supplementation? When (at which age) does NAD begin to drop?Lena,
No-one really knows how much the recommended dosage varies between individuals, but most people believe that young people would see much less benefit, while older, sicker people have less NAD+ available and would benefit from a higher dosage.
So, bodyweight matter, but age and health probably a lot more so.
Posted 05 November 2017 - 03:44 PM
Lena,
No-one really knows how much the recommended dosage varies between individuals, but most people believe that young people would see much less benefit, while older, sicker people have less NAD+ available and would benefit from a higher dosage.
So, bodyweight matter, but age and health probably a lot more so.
Thank you able. I am 47, so I think I'll stick with the 300mg/day dosing.
Recon, I'm sure I've seen this chart posted here before, but this might help answer your question:
https://www.research...-B-FemalesA-NAD
Posted 05 November 2017 - 10:28 PM
Posted 06 November 2017 - 12:23 AM
Thanks! That chart suggests that we'll be having decreasing production of NAD+ since birth. I guess that means it’s be best to take them as soon as possible.Lena,
No-one really knows how much the recommended dosage varies between individuals, but most people believe that young people would see much less benefit, while older, sicker people have less NAD+ available and would benefit from a higher dosage.
So, bodyweight matter, but age and health probably a lot more so.
Thank you able. I am 47, so I think I'll stick with the 300mg/day dosing.
Recon, I'm sure I've seen this chart posted here before, but this might help answer your question:
https://www.research...-B-FemalesA-NAD
Posted 06 November 2017 - 01:39 PM
Thanks! That chart suggests that we'll be having decreasing production of NAD+ since birth. I guess that means it’s be best to take them as soon as possible.
Lena,
No-one really knows how much the recommended dosage varies between individuals, but most people believe that young people would see much less benefit, while older, sicker people have less NAD+ available and would benefit from a higher dosage.
So, bodyweight matter, but age and health probably a lot more so.
Thank you able. I am 47, so I think I'll stick with the 300mg/day dosing.
Recon, I'm sure I've seen this chart posted here before, but this might help answer your question:
https://www.research...-B-FemalesA-NAD
Are you (or is your friend) going to take some others to try and maximise NAD+ production? Nicotinic Acid for the different pathways and possibly resveratrol to up NAMPT?
I take a B-Complex that has Niacin in it. I was taking 500mg of Niacinamide before learning about NR and am thinking about adding it back in.
Edited by LenaW, 06 November 2017 - 01:52 PM.
Posted 06 November 2017 - 02:05 PM
I take a B-Complex that has Niacin in it. I was taking 500mg of Niacinamide before learning about NR and am thinking about adding it back in.That chart suggests that we'll be having decreasing production of NAD+ since birth. I guess that means it’s be best to take them as soon as possible.
Are you (or is your friend) going to take some others to try and maximise NAD+ production? Nicotinic Acid for the different pathways and possibly resveratrol to up NAMPT?
There were some talks in some old posts about Niacinamide being an inhibitor to the Sirtuins genes which are the genes you’d want to activate.
Edited by Michael, 13 November 2017 - 08:48 PM.
trim quotes
Posted 06 November 2017 - 02:29 PM
Yes! I have read going back several years here and it made my head spin. Here is the more recent review that has led me to consider adding Niacinamide back in. I was planning on spending some time today on a Pubmed search on the topic.
https://www.ncbi.nlm...pubmed/28417163
Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells.
Hwang ES, Song SB.
Cell Mol Life Sci. 2017 Sep;74(18):3347-3362. doi: 10.1007/s00018-017-2527-8. Epub 2017 Apr 17. Review.
PMID:
28417163
Posted 06 November 2017 - 05:43 PM
That’s really interesting. I’ll take a look at that too!
Yes! I have read going back several years here and it made my head spin. Here is the more recent review that has led me to consider adding Niacinamide back in. I was planning on spending some time today on a Pubmed search on the topic.
https://www.ncbi.nlm...pubmed/28417163
Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells.
Hwang ES, Song SB.
Cell Mol Life Sci. 2017 Sep;74(18):3347-3362. doi: 10.1007/s00018-017-2527-8. Epub 2017 Apr 17. Review.
PMID:
28417163
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