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Activating Sirtuins During Mealtime

resveratrol pterostilbene stilbenoid sirt sirtuin fasting caloric restriction activation sirt1

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#1 recon

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Posted 14 November 2017 - 12:15 AM


Given that sirtuins are activated during fasting or caloric restrictions, should the focus on the maximisation of sirtuin activation center around mealtimes?

Therefore, doesn’t it make more sense to take sirtuin activators like resveratrol and pterostilbene before or during mealtime?

The absorption of resveratrol (and possibly pterostilbene) is largely unaffected by the intake of food and should be faster without food.

I postulate that we should take them on an empty stomach 0.5 hour before food [1]. That way, resveratrol (or pterostilbene) will have maximum concentration and hopefully begin activating sirtuins before food is being consumed and will keep activating sirtuins even in the presence of food (or at the very least blunt the inhibitions).

The hypothesis for this is since sirtuins are activated away from food such as time of fasting (or in essence, during sleep away from dinner), there should be no point taking them then. Rather, we should blunt the inhibition of sirtuin by the intake of food so that sirtuins are activated more throughout the day.

One problem I see may be that food is always almost certainly blunting sirtuin activation and that may in effect wastes the stilbenoids/sirtuin activators that were consumed. I would need more data on either 1) the extent of sirtuin activation by those activators AND 2) the extent of sirtuin inhibition by food, OR 3) the extent of sirtuin activation by those activators in the presence of food.

[1] Effect of food on the pharmacokinetic profile of trans-resveratrol. Vaz-da-Silva M, et al. Int J Clin Pharmacol Ther. 2008 Nov;46(11):564-70. PMID 19000554.
https://www.ncbi.nlm...ubmed/19000554/

Edited by recon, 14 November 2017 - 12:17 AM.

  • Good Point x 1





Also tagged with one or more of these keywords: resveratrol, pterostilbene, stilbenoid, sirt, sirtuin, fasting, caloric, restriction, activation, sirt1

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