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New drug that induce an anti-oxidant effect and protect mitochondrial function

mitochondria alzheimer anti-oxidant

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#1 AdamI

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Posted 21 November 2017 - 12:38 PM


So was wondering if it protects mitochondria in the nerve system it should also protect it in other cells right?

There is no "special" mitochondria in the nerves system?

 

NEW YORK, NY – November 21, 2017 – New data published in the current issue of the peer-reviewed scientific journal Neurotoxicity Research[1] confirm that sigma-1 agonists, including multiple investigational compounds from Anavex Life Sciences Corp. (“Anavex” or the “Company”) (NASDAQ: AVXL), induce an anti-oxidant effect and protect mitochondrial function in pathological central nervous system conditions. In addition, another recent publication in the peer-reviewed scientific journal, Behavioural Brain Research[2], confirms that the absence of sigma-1 receptor function exacerbates amyloid toxicity and increases learning impairments in pharmacologic and genetic mouse models of Alzheimer’s disease.

Lead author of both publications, Tangui Maurice, PhD, Professor at INSERM Montpellier noted, “Both findings are consistent with the concept that sigma-1 receptor activity seems to be essential for cell survival under stress with the ability to counter the different manifestations of Alzheimer’s disease and other neurodegenerative pathologies.”

Mitochondrial dysfunction and oxidative damage are key factors involved in the pathology of many neurodegenerative diseases. Research shows that oxidative damage occurs in the brains of people with Alzheimer’s disease prior to the onset of significant plaque pathology [3].

 

http://www.anavex.co...data_alzheimer/

 







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